Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 29, 2026, 1:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 745–756 of 5,333 matching trials for Depression.

Live ClinicalTrials.gov results.

Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

Live official records

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Conditions: Suicidal Ideation
Interventions: WeCare; Behavioral
Lead sponsor: New York University; Other
Eligibility: 12 Years to 19 Years
Enrollment: 2,200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Sleep, Anxiety, Depression, Pain
Interventions: fsCBD Cannabidiol, bsCBD Cannabidiol, Placebo; Drug
Lead sponsor: University of Colorado, Boulder; Other
Eligibility: 60 Years and older
Enrollment: 385 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Chronic Pain, Musculoskeletal Pain, Depression, Health Equity
Interventions: Coaching and Decision Aid; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 304 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Multiple Sclerosis, Multiple Sclerosis (MS)
Interventions: My MS Toolkit; Device
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Anxiety, Depression, Conduct Disorder, Stress
Interventions: Practicing the Opposite (PTO), Usual Clinical Care; Behavioral · Other
Lead sponsor: Harvard University; Other
Eligibility: 9 Years to 17 Years
Enrollment: 226 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 5
States / cities: Indianapolis, Indiana • Boston, Massachusetts • Concord, Massachusetts + 1 more

Conditions: Cancer of Breast, Depressive Symptoms, Cancer Pain
Interventions: CAI, CAPA; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years and older · Female only
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Lewy Bodies Disease, Depression Disorder, Caregiver Burden, Caregivers
Interventions: VOCALE LBD: Virtual Online Communities for Aging Life Experiences: Lewy Body Dementia, Standard of Care Educational Materials; Behavioral · Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Major Depressive Disorder, MDD, Depression, Major Depressive Episode
Interventions: transcranial direct current stimulation (tDCS); Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder
Interventions: Left DLPFC tDCS, Right DLPFC tDCS, Cognitive task; Device · Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 20 Years to 55 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Major Depressive Disorder, Post-Traumatic Stress Disorder
Interventions: Ketamine; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 130 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Depressive Disorder, Major, Anhedonia
Interventions: Aticaprant, Placebo; Drug · Other
Lead sponsor: Janssen Research & Development, LLC; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 31
States / cities: Little Rock, Arkansas • Encino, California • Newport Beach, California + 26 more

Conditions: Depression, Drive
Interventions: F 18 AV-1451 (Flortaucipir), [11C]-Pittsburgh Compound B ([11C]PiB); Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 65 Years and older
Enrollment: 150 participants
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

WeCare: A System of Care for Black Youth

Cannabidiol and Older Adult Cannabis Users

Equipping Patients Using Interventions for Pain and Depression

My MS Toolkit: An Internet-Based Depression Self-Management Program for Adults Living With Multiple Sclerosis

Digital Single Session Intervention for Youth Mental Health

Cancer Pain Management Using a Web-based Intervention

VOCALE LBD: Online Peer Support for Caregivers of People With Lewy Body Dementia

tDCS: Sleep to Mood in Depression (S2M-D)

Evaluating tDCS Brain-stimulation in Depression Using MRI

Imaging SV2A in Mood Disorders

A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure

Depression and Driving

About this Depression clinical trials directory page