Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 29, 2026, 1:49 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 853–864 of 5,335 matching trials for Depression.

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Live official records

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Conditions: Depression, Anxiety
Interventions: Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Florida State University; Other
Eligibility: 4 Years to 17 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Major Depressive Disorder
Interventions: Centanafadine, Escitalopram, Placebo; Drug
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 337 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 62
States / cities: Yuma, Arizona • Bryant, Arkansas • Glendale, California + 53 more

Conditions: Lung Non-Small Cell Carcinoma, Unipolar Depression
Interventions: Biospecimen Collection, Counseling, Interview, Psilocybin, Survey Administration; Procedure · Other · Drug
Lead sponsor: Alan Davis; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Major Depressive Disorder (MDD)
Interventions: Sham TMS, Active TMS; Device
Lead sponsor: Subha Subramanian; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression
Interventions: Welbutrin XL, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Suicide, Depression, Caregiver Burden, Physical Health, Inflammation
Interventions: Adapted Dialectical Behavior Therapy; Behavioral
Lead sponsor: Texas Tech University; Other
Eligibility: 50 Years to 120 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Postpartum Depression, Postpartum Anxiety, Cardiometabolic Syndrome
Interventions: MOMI PODS, Enhanced Usual Care (EUC); Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: Female only
Enrollment: 384 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Postpartum Depression
Interventions: RE104 for Injection; Drug
Lead sponsor: Reunion Neuroscience Inc; Industry
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 38
States / cities: Birmingham, Alabama • Tucson, Arizona • Santa Monica, California + 31 more

Conditions: Chronic Pain, Chronic Pain (Back / Neck)
Interventions: No Intervention: Observational Cohort; Other
Lead sponsor: Evidence In Motion; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Story City, Iowa

Conditions: Major Depression
Interventions: D-Cycloserine (DCS), Continuous theta-burst stimulation (cTBS), Transcranial Magnetic Stimulation Sham, Memantine, Lorazepam (drug), Baclofen, Placebo; Drug · Device
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Depression, Drug Use
Interventions: Families with Pride ("Familias con Orgullo"); Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 13 Years to 19 Years
Enrollment: 306 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Coral Gables, Florida

Conditions: Depression, HIV Infection
Interventions: Suubi-Mhealth; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 14 Years to 17 Years
Enrollment: 248 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Youth Emotional and Behavioral Treatment Study

Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder

Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer

Mechanisms Of Orbitofrontal Stimulation in Depression

Neurobiological Underpinnings of Placebo Response in Depression

Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD

The Mom and Infant Outcomes (MOMI) Study

RE104 Safety and Efficacy Study in Postpartum Depression

Chronic Pain, Emotions and Professional Football

Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression

Families With Pride ("Familias Con Orgullo").

Suubi-Mhealth: A Mobile Health Intervention to Address Depression Among Youth

About this Depression clinical trials directory page