Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 29, 2026, 5:58 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 901–912 of 5,335 matching trials for Depression.

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Conditions: Depression, Anxiety, Bipolar Disorder
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years and older
Enrollment: 193 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Pregnancy, Postpartum Depression, Infant Development, Infant Conditions
Interventions: Rosie the Chatbot; Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 14 Years to 99 Years · Female only
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: College Park, Maryland

Conditions: Suicidal Behaviors, Suicide Ideation, Depression/Anxiety
Interventions: Aviva; Behavioral
Lead sponsor: University of Memphis; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Colorado Springs, Colorado

Conditions: Major Depressive Disorder
Interventions: High Dose Resistance Exercise Training, Low Dose Resistance Exercise Training Group; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 2
States / cities: Ames, Iowa • Madison, Wisconsin

Conditions: Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia)
Interventions: Mindful Self-Compassion; Behavioral
Lead sponsor: Georgetown University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Treatment Resistant Depression
Interventions: MK-1942, Placebo; Drug
Lead sponsor: Merck Sharp & Dohme LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 45
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Bellflower, California + 40 more

Conditions: Major Depressive Disorder
Interventions: No intervention will be administered as part of this study.; Other
Lead sponsor: Usona Institute; Other
Eligibility: 21 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Lauderhill, Florida

Conditions: Autism, Depression, Autism Spectrum Disorder With Impaired Functional Language, Autism Spectrum Disorder
Interventions: BeatIt-MV; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Piscataway, New Jersey

Conditions: Depressive Symptoms
Interventions: Urban Walk, Nature Walk, Active Nature Walk; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 138 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 2
States / cities: Seattle, Washington

Conditions: Depression - Major Depressive Disorder, Psilocybin, Cognitive Behavioral Therapy
Interventions: Psilocybin (drug), Group Cognitive Behavioral Therapy; Drug · Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 60 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: PTSD, Depression, Alcohol Use Disorder, Opioid Use Disorder
Interventions: Participatory System Dynamics (PSD), Audit and Feedback (AF); Other
Lead sponsor: Palo Alto Veterans Institute for Research; Other
Eligibility: 18 Years and older
Enrollment: 720 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Major Depressive Disorder
Interventions: Heart rate variability biofeedback; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years to 27 Years
Enrollment: 252 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Mental Health Impact of the COVID-19 Pandemic on Amish and Mennonite Participants in AMBiGen

Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication

Examining the Efficacy of a Digital Therapeutic to Prevent Suicidal Behaviors

RESISTance Exercise for Depression Trial

Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method

Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006)

PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder

Adapting BA for Minimally Verbal Autistic Adults

Benefits of Outdoor Walks in Reducing Depressive Symptoms

Group PACBT for Depression

Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care

Regulation of Affect and Physiology in Depression

About this Depression clinical trials directory page