Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 30, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 30, 2026, 12:33 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 997–1008 of 5,335 matching trials for Depression.

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Live official records

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Conditions: Depression, Unipolar, Anxiety Disorders, Post Traumatic Stress Disorder
Interventions: Outreach/navigator, Auxiliary to care, Stepped care and task shifting; Other
Lead sponsor: Drexel University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 603 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depressed Mood
Interventions: Not listed
Lead sponsor: Salma Health, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 5,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2037
U.S. locations: 2
States / cities: La Jolla, California • Laguna Hills, California

Conditions: Bipolar Depression
Interventions: Cariprazine; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 60 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder, Treatment Resistant Depression
Interventions: Personalized iTBS, Non-Personalized iTBS, Sham iTBS; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Stanford, California

Conditions: Treatment Resistant Depression
Interventions: Synergy, Epidural cortical stimulation; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years to 80 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Depression, Anxiety
Interventions: STEP-UP (transdiagnostic behavioral therapy for pediatric anxiety and depression), ARC (assisted referral to community care); Behavioral
Lead sponsor: San Diego State University; Other
Eligibility: 8 Years to 16 Years
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Depressive Disorder, Major
Interventions: Duloxetine, Vortioxetine; Drug
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 9,586 participants
Timeline: 2015 – 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Depression, Anxiety
Interventions: VIPA Treatment Program, Alexa with Guidebook; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide, Suicidal Ideation
Interventions: BE-SMART-DR, psychoeducational control comparator condition (CC); Behavioral
Lead sponsor: Yale University; Other
Eligibility: 16 Years to 29 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Parkinson's Disease
Interventions: Ketamine, Remimazolam; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 40 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Depression, Hypertension
Interventions: Mindfulness-Based Stress Reduction (MBSR; CALM-Chicago Study); Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Depression
Interventions: Adaptive Messaging Intervention, Non-Adaptive Messaging Intervention, Psychoeducation-Only Control; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Chicago, Illinois

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos

ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1

Dopamine D3 Receptor Occupancy in Bipolar Depression

Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression

Epidural Cortical Stimulation for Depression

Behavioral Telehealth in Low-resource Primary Care Settings for Anxiety and Depression in Youth

Combining Data Sources to Identify Effect Moderation for Personalized Mental Health

Voice Activated Personal Assistant for Depression Among Older Adults

Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms

Ketamine for Veterans With Parkinson's Disease

Community-based Approach to Lowering Stress Through Mindfulness

Adaptive Messaging to Support Depression Self-Management

About this Depression clinical trials directory page