Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 30, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 30, 2026, 1:11 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 1009–1020 of 5,335 matching trials for Depression.

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Live official records

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Conditions: Depressive Disorder, Treatment-Resistant
Interventions: tDCS; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Intervention, Control
Interventions: Dyadic Intervention, Patient Only Intervention; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 21 Years and older
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cancer, Depression, Fatigue, Pain, Sleep
Interventions: Stepped collaborative care intervention, Enhanced Usual Care; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 21 Years to 100 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2028 – 2032
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression, OCD, Anxiety Depression
Interventions: Patients treated with NeuroStar TMS, Patients treated with Esketamine; Device · Drug
Lead sponsor: Neuronetics; Other
Eligibility: 5 Years to 100 Years
Enrollment: 12,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2035
U.S. locations: 1
States / cities: Malvern, Pennsylvania

Conditions: Cardiac Surgery, Older Adults, Depression, Anxiety
Interventions: Behavioral activation, Medication optimzation, Care as usual; Behavioral · Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 60 Years and older
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Orthopedic Surgery, Older Adults, Depression, Anxiety
Interventions: Behavioral activation, Medication optimzation, Care as usual; Behavioral · Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 60 Years and older
Enrollment: 116 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Depression, Obsessive-Compulsive Disorder, Anxiety Depression
Interventions: NeuroStar Advanced TMS Therapy System; Device
Lead sponsor: Neuronetics; Other
Eligibility: 5 Years to 120 Years
Enrollment: 156,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2035
U.S. locations: 1
States / cities: Malvern, Pennsylvania

Conditions: Older Cancer Patients
Interventions: Patient Interviews, newly developed questionnaire, Pilot Testing the Draft Measure; Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 70 Years and older
Enrollment: 329 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder
Interventions: AGN-241751, Placebo; Drug
Lead sponsor: Syndeio Biosciences, Inc; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 226 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 5
States / cities: Phoenix, Arizona • Garden Grove, California • Atlanta, Georgia + 2 more

Conditions: Depression, Anxiety, Substance Use, Stress, Psychological, Stress, Emotional, Alcohol Use, Unspecified, Drug Use, Covid19
Interventions: Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell; Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years to 70 Years
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Major Depressive Disorder (MDD)
Interventions: Ropanicant, Placebo; Drug
Lead sponsor: Suven Life Sciences Limited; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 214 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 35
States / cities: Little Rock, Arkansas • Rogers, Arkansas • Anaheim, California + 31 more

Conditions: Bipolar Depression
Interventions: Probiotic Supplement, Inert Compound; Biological
Lead sponsor: Sheppard Pratt Health System; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Towson, Maryland

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

Adaptive tDCS for Treatment-Resistant MDD

A Sleep Intervention for Cancer Patients and Their Caregivers

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments

Behavioral Activation and Medication Optimization In Older Adults Undergoing Cardiac Procedures

Perioperative Mental Health in Orthopedic Surgery

Retrospective Analyses of TrakStar Database

Identifying and Measuring Depression in Older Cancer Patients

Zelquistinel in the Treatment of Adults With Major Depressive Disorder

Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use

Study to Evaluate Efficacy and Safety of Ropanicant in MDD Patients

Probiotics to Prevent Relapse After Hospitalization for Bipolar Depression

About this Depression clinical trials directory page