Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 30, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 30, 2026, 3:42 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 1045–1056 of 5,335 matching trials for Depression.

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Live official records

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Conditions: Depressive Disorder, Major
Interventions: BI 1569912, Placebo; Drug
Lead sponsor: Boehringer Ingelheim; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 243 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 21
States / cities: Tucson, Arizona • Oceanside, California • Orange, California + 17 more

Conditions: Chronic Low Back Pain
Interventions: MBM, VNSM; Behavioral · Device
Lead sponsor: Florida State University; Other
Eligibility: 50 Years to 85 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Depression, Acute Pain, Chronic Pain
Interventions: Pharmacogenetic testing, Clinical decisions support; Other
Lead sponsor: Duke University; Other
Eligibility: 8 Years and older
Enrollment: 4,284 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 14
States / cities: Wilmington, Delaware • Gainesville, Florida • Jacksonville, Florida + 6 more

Conditions: Anhedonia, Depression in Adults, Anxiety
Interventions: Positive Affect Treatment; Behavioral
Lead sponsor: Southern Methodist University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Depression - Major Depressive Disorder
Interventions: Mediterranean Diet, Time-Restricted Eating; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use, Depression, Post-traumatic Stress Disorder (PTSD)
Interventions: Ketamine, standard general anesthesia; Drug
Lead sponsor: Texas Tech University Health Sciences Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Lubbock, Texas

Conditions: Depression
Interventions: TREE-Connect, Clinician-delivered psychotherapy; Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Consumption, Postoperative, Pain After Surgery, Opioid Dependency
Interventions: Opioid tapering with CBT and education, Opioid tapering with education alone; Other
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadephia, Pennsylvania

Conditions: Child Anxiety, Depression
Interventions: Kind Minds Program; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 12 Years to 17 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Imperial, California

Conditions: Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
Interventions: Low Field Magnetic Stimulation; Device
Lead sponsor: Mclean Hospital; Other
Eligibility: 50 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Psoriasis, Depressive Symptoms
Interventions: Coach-guided smartphone delivered CBT program.; Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Acute Pain
Interventions: Pharmacogenetic testing, Clinical decisions support; Other
Lead sponsor: Duke University; Other
Eligibility: 8 Years and older
Enrollment: 1,602 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 11
States / cities: Wilmington, Delaware • Gainesville, Florida • Jacksonville, Florida + 6 more

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

A Study to Test Different Doses of BI 1569912 in People With Depression Who Take Anti-depressive Medicine

MBM and taVNS for Low Back Pain and Depressive Symptoms

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center)

Positive Affect Treatment for Spanish-Speaking Individuals

Nutritional Intervention for College Students With Depression

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

Technology dRiven Enhancement to Engage & Connect

Preoperative Opioid Tapering Before Spine Surgery

Kind Minds Program for Youth With Anxiety and Depression

Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

Smart Phone Delivered Cognitive Behavioral Therapy for Adults With Psoriasis and Co-Morbid Depression Symptoms

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)

About this Depression clinical trials directory page