Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 30, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 30, 2026, 2:16 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 1033–1044 of 5,335 matching trials for Depression.

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Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

Live official records

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Conditions: Bipolar Disorder
Interventions: Cannabidiol; Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Treatment Resistant Depression
Interventions: Ketamine Infusion plus RO DBT; Combination Product
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Post Partum Depression
Interventions: ROSE Program; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years · Female only
Enrollment: 308 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder, Suicidal Ideation
Interventions: Trier Social Stress Test; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 60 Years
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 2
States / cities: Birmingham, Alabama • Huntsville, Alabama

Conditions: Depression, Anxiety
Interventions: App-based Cognitive Behavioral Therapy (CBT), Psychotherapy; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 13 Years to 22 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: New Brunswick, New Jersey • Brooklyn, New York • Glen Oaks, New York

Conditions: Treatment Resistant Depression
Interventions: Active TBS-DLPFC, Sham TBS-DLPFC; Device
Lead sponsor: Stanford University; Other
Eligibility: 22 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Stanford, California

Conditions: Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
Interventions: More Individualized Care: Assessment and Recovery through Engagement (MI-CARE); Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 805 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Indianapolis, Indiana • Seattle, Washington

Conditions: Major Depressive Episode Associated With Bipolar II Disorder
Interventions: NMRA-335140 80 mg, Placebo; Drug
Lead sponsor: Neumora Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 21
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Garden Grove, California + 18 more

Conditions: Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
Interventions: "Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP); Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Suicide, Schizophrenia, Bipolar Disorder, Post Traumatic Stress Disorder, Major Depressive Disorder
Interventions: Affective Awareness; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Major Depressive Disorder
Interventions: remote internet-based cognitive behavior therapy (eCBT); Behavioral
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years and older
Enrollment: 1,280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 7
States / cities: Louisville, Kentucky • Cedar Grove, West Virginia • Glenville, West Virginia + 4 more

Conditions: Alcohol Use Disorder
Interventions: Virtual Reality (VR) -nature treatment, Survey completion; Device · Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Ann Arbor, Michigan

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder

KET-RO Plus RO DBT for Treatment Resistant Depression

ROSE in Sunset Park

MicroRNA Correlates of Childhood Maltreatment and Suicidality

SilverCloud as a School-Based Intervention for Vulnerable Youth

Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation

More Individualized Care: Assessment and Recovery Through Engagement

To Evaluate the Effects of NMRA-335140 on Symptoms of Major Depression in Participants With Bipolar II Disorder.

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

Alexithymia Intervention for Suicide

Appalachian Mind Health Initiative

Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD)

About this Depression clinical trials directory page