Condition Directory

Obesity clinical trials

Directory of U.S. ClinicalTrials.gov public records for Obesity. Browse Obesity recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 28, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 7:37 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Obesity studies are organized in the registry

Obesity research spreads across several neighboring registry terms — “overweight,” “weight loss,” and “metabolic syndrome” all label closely related studies — so checking more than one term gives a fuller picture. The portfolio includes many behavioral and lifestyle studies alongside drug trials, which makes the study-type filter (interventional vs. observational) more informative than usual.

Terms that often appear in related listings

weight loss overweight metabolic syndrome bariatric

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 109–120 of 6,023 matching trials for Obesity.

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Conditions: Hypercholesterolemia
Interventions: Alirocumab; Drug
Lead sponsor: Regeneron Pharmaceuticals; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 438 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 34
States / cities: Anniston, Alabama • Cullman, Alabama • Anaheim, California + 30 more

Conditions: Hypertension, Overweight, Obesity, Cardiovascular Diseases, Sedentary Behavior, Low Physical Fitness
Interventions: Active older Adults; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 50 Years to 95 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2028
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Obesity, Overweight and/or Obesity, Overweight, Treatment Of Obesity
Interventions: Semaglutide, Berobenatide, Tirzepatide; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 660 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 16
States / cities: Birmingham, Alabama • Los Angeles, California • Santa Ana, California + 13 more

Conditions: Ultra-Processed Food Intake, Obesity & Overweight
Interventions: Introductory Educational Workshop, Standard Dietary Change (ON/OFF), Cognitive Dissonance Strategies (ON/OFF); Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years to 70 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Springfield, Oregon

Conditions: Childhood Obesity
Interventions: Attentional bias to food cues; Behavioral
Lead sponsor: Trustees of Dartmouth College; Other
Eligibility: 27 Months to 72 Months
Enrollment: 330 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Hanover, New Hampshire

Conditions: Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease, PreDiabetes
Interventions: Not listed
Lead sponsor: University of Michigan; Other
Eligibility: 14 Years to 18 Years
Enrollment: 175 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Obesity, Overweight
Interventions: LY4174794, Placebo; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 116 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: San Antonio, Texas • Salt Lake City, Utah

Conditions: Prader-Willi Syndrome
Interventions: Repetitive Transcranial Magnetic Stimulation (rTMS); Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Obesity (BMI>30), Insulin Resistance
Interventions: human insulin; Drug
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2032
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Obesity, Type2diabetes, NAFLD
Interventions: Glucagon response study; Drug
Lead sponsor: Adrian Vella; Other
Eligibility: 25 Years to 65 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Obesity, Overweight, or Chronic Weight Management
Interventions: aleniglipron or placebo; Drug
Lead sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics; Industry
Eligibility: 18 Years to 79 Years
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 11
States / cities: Phoenix, Arizona • Chicago, Illinois • Richfield, Minnesota + 8 more

Conditions: Type2diabetes, Heart Failure, Obesity
Interventions: Community Champions, Homegrown Heroes; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 30 Years to 70 Years
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Baltimore, Maryland • Hagerstown, Maryland

About this Obesity clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Obesity as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Obesity.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Obesity clinical trials

How Obesity studies are organized in the registry

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Live official records

A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity

Dietary Interventions to Reduce Ultra-Processed Food Intake

Genetic Risk, Parental Feeding Practices, and Appetitive Traits in Early Life

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Cerebellar TMS and Satiety in Prader-Willi Syndrome

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

The Effects of Glucagon on Hepatic Metabolism

Aleniglipron Phase 2 Body Composition Study

Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

About this Obesity clinical trials directory page