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ClinicalTrials.gov public records Last synced Sep 13, 2026, 10:15 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Advanced Heart Failure Clear all
Completed Phase 4 Interventional Results available

Personalized Treatments for Depressive Symptoms in Patients With Advanced Heart Failure

NCT03688100
View directory record Official record
Conditions
Depression, Heart Failure
Interventions
Behavioral Activation Therapy, Medication Management
Behavioral · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2024 · Synced Sep 13, 2026, 10:15 PM EDT
Completed Phase 3 Interventional

Improving Clinician Communication Skills (ICCS)

NCT00687349
View directory record Official record
Conditions
Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD), Restrictive Lung Disease, Congestive Heart Failure, End Stage Liver Disease
Interventions
Training Program Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
6,086 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
4
States / cities
Charleston, South Carolina • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 15, 2014 · Synced Sep 13, 2026, 10:15 PM EDT
Completed No phase listed Observational

REGISTRY EVALUATION OF VITAL INFORMATION FOR VADs IN AMBULATORY LIFE

NCT01369407
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
No Intervention
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
21
States / cities
Birmingham, Alabama • Beverly Hills, California • Aurora, Colorado + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Sep 13, 2026, 10:15 PM EDT
Completed No phase listed Observational

Implantation of the HeartMate 3 in Subjects With Heart Failure Using Surgical SWIFT HM3 PMS

NCT04548128
View directory record Official record
Conditions
Advanced Refractory Left Ventricular Heart Failure
Interventions
HeartMate 3 Left Ventricular Assist System (HM3 LVAS)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
31
States / cities
Little Rock, Arkansas • Palo Alto, California • Aurora, Colorado + 26 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Sep 13, 2026, 10:15 PM EDT
Not listed Not applicable Interventional

POsition of Leads in Advanced heaRt Failure: the POLAR Study

NCT01515761
View directory record Official record
Conditions
Cardiac Resynchronization Therapy, Heart Failure
Interventions
Postero-lateral, Antero-Lateral
Procedure
Lead sponsor
Sergio Thal, M.D.
Federal
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
2
States / cities
Tucson, Arizona • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 23, 2012 · Synced Sep 13, 2026, 10:15 PM EDT
Completed Not applicable Interventional Results available

A Clinical Trial to Evaluate the HeartWare™ Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL)

NCT01966458
View directory record Official record
Conditions
Chronic Heart Failure
Interventions
HeartWare® VAS (HVAD), Control LVAD
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
47
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 37 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2020 · Synced Sep 13, 2026, 10:15 PM EDT
Withdrawn No phase listed Observational

Non-invasive Evaluation of Heart Transplant Rejection- Pilot Study

NCT00572286
View directory record Official record
Conditions
Advanced Heart Failure, Heart Transplantation
Interventions
Not listed
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 16, 2009 · Synced Sep 13, 2026, 10:15 PM EDT
Withdrawn Not applicable Interventional

End-Of-Life Decision Making and Preparedness Planning Among Heart Failure Patients Hospitalized for Advanced Disease

NCT02398617
View directory record Official record
Conditions
Heart Failure
Interventions
Decision Making Intervention
Other
Lead sponsor
Saint Luke's Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 18, 2021 · Synced Sep 13, 2026, 10:15 PM EDT
Completed No phase listed Observational

Shear Wave Elastography

NCT04493346
View directory record Official record
Conditions
Heart Failure, Transplant; Failure, Heart, Decompensated Heart Failure, Fibrosis, Liver, Cirrhosis, Liver
Interventions
Not listed
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Sep 13, 2026, 10:15 PM EDT
Completed No phase listed Observational

Effectiveness of NephroCheckTM Test to Predict Acute Kidney Injury Following Advanced Cardiac Replacement Therapies

NCT02827448
View directory record Official record
Conditions
Acute Kidney Injury, Heart Failure
Interventions
Not listed
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Sep 13, 2026, 10:15 PM EDT
Recruiting Not applicable Interventional

Sustaining Home Heart Failure Palliative Care in Rural Appalachia

NCT06791850
View directory record Official record
Conditions
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Interventions
HF-FamPALhomeCARE
Behavioral
Lead sponsor
West Virginia University
Other
Eligibility
45 Years to 80 Years
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 13, 2026, 10:15 PM EDT
Not yet recruiting Not applicable Interventional

Palliative Care Intervention to Improve Health Related Quality of Life for Patients on Long-Term LVAD Support

NCT07445932
View directory record Official record
Conditions
Advanced Heart Failure, Mechanical Circulatory Support, Left Ventricular Assist Device, Palliative Care
Interventions
Palliative care intervention
Behavioral
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 13, 2026, 10:15 PM EDT
Recruiting Not applicable Interventional

HIV+ Deceased Donor Heart Transplant Study for HIV+ Recipients

NCT06659952
View directory record Official record
Conditions
HIV Infection, Advanced End Stage Heart Failure
Interventions
HIV-positive heart transplant
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2034
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 13, 2026, 10:15 PM EDT
Completed Phase 2 Interventional

PROCLAIM: Effect of AC2592 Administered by Continuous Subcutaneous Infusion in Subjects With Advanced Chronic Congestive Heart Failure

NCT00099580
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
AC2592, placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
29
States / cities
Beverly Hills, California • Mission Viejo, California • New Haven, Connecticut + 26 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2015 · Synced Sep 13, 2026, 10:15 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers

NCT07159269
View directory record Official record
Conditions
Cardiovascular Disease Acute, Emergency Department Patient, Heart Failure Acute, Pulmonary Embolism (Diagnosis), Point of Care Ultrasound (POCUS), Cardiac Tamponade, Pericardial Effusion, Diagnostic Imaging, Medical Training, Implementation Science
Interventions
Cardiac point-of-care ultrasound (POCUS) training and clinical pathway
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 13, 2026, 10:15 PM EDT
Completed No phase listed Observational Results available

Post- Approval Study on Patients Who Received a HeartWare HVAD® During IDE Trials

NCT01832610
View directory record Official record
Conditions
Heart Failure
Interventions
HeartWare® VAS
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
25
States / cities
Stanford, California • Washington D.C., District of Columbia • Gainesville, Florida + 21 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Sep 13, 2026, 10:15 PM EDT
Not yet recruiting Phase 1Phase 2 Interventional

HiCM-188 Cell Therapy in Adults With Advanced Heart Failure Undergoing Heart Bypass Surgery

NCT07646210
View directory record Official record
Conditions
Advanced Heart Failure, Ischemic Heart Failure
Interventions
HiCM-188 Cells
Drug
Lead sponsor
HELP Therapeutics Co., Ltd.
Industry
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 13, 2026, 10:15 PM EDT
Terminated Phase 3 Interventional Results available

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure

NCT00608140
View directory record Official record
Conditions
Mitral Valve Insufficiency, Heart Failure
Interventions
Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
8
States / cities
Atlanta, Georgia • Boston, Massachusetts • Minneapolis, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Sep 13, 2026, 10:15 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Prospective Observation of Exercise Parameters in Advanced Heart Failure

NCT01210573
View directory record Official record
Conditions
Advanced Heart Failure
Interventions
adjustment of LVAD or pacemaker
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 17, 2014 · Synced Sep 13, 2026, 10:15 PM EDT
Not listed Not applicable Interventional

Effect of DASH Eating Pattern on Heart Failure Outcomes

NCT03538990
View directory record Official record
Conditions
Heart Failure NYHA Class III
Interventions
DASH Eating Pattern
Other
Lead sponsor
University of Georgia
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Sep 13, 2026, 10:15 PM EDT
Completed Phase 2 Interventional

STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH

NCT00277875
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
ALT-711 (alagebrium chloride)
Drug
Lead sponsor
Synvista Therapeutics, Inc
Industry
Eligibility
50 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 26, 2009 · Synced Sep 13, 2026, 10:15 PM EDT
Completed No phase listed Observational

Neuron Specific Enolase in Ventricular Assist Device Recipients

NCT01643551
View directory record Official record
Conditions
Advanced Heart Failure, Left Ventrucular Assist Device
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 17, 2014 · Synced Sep 13, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Hemodynamic Study of Balloon Counterpulsation in Advanced Heart Failure

NCT03001674
View directory record Official record
Conditions
Heart Failure
Interventions
Conductance catheterization
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Sep 13, 2026, 10:15 PM EDT
Completed Not applicable Interventional Results available

Chronicle Offers Management to Patients With Advanced Signs and Symptoms of Heart Failure (COMPASS-HF)

NCT00643279
View directory record Official record
Conditions
Heart Failure
Interventions
Chronicle Implantable Hemodynamic Monitor, Standard of Care
Device · Other
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2013
U.S. locations
28
States / cities
Birmingham, Alabama • Loma Linda, California • Los Angeles, California + 22 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2023 · Synced Sep 13, 2026, 10:15 PM EDT