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ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:19 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 102 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Articular Cartilage Clear all

Conditions: Knee Injury
Interventions: Placement of allograft CR Plug in primary injury site; Procedure
Lead sponsor: RTI Surgical; Industry
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 3
States / cities: Los Angeles, California • Denver, Colorado • Indianapolis, Indiana

Conditions: Femoroacetabular Impingement
Interventions: dGEMERIC MRI technique; Other
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 10 Years to 35 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Chondromalacia Patella, Patellofemoral Pain Syndrome
Interventions: Synvisc-One™, Sham Treatment; Device · Other
Lead sponsor: University of Virginia; Other
Eligibility: 15 Years to 45 Years
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Chondral Defect, Articular Cartilage Defect
Interventions: autologous cultured chondrocytes on porcine collagen membrane, Bone Marrow Stimulation; Biological · Procedure
Lead sponsor: Vericel Corporation; Industry
Eligibility: 17 Years to 65 Years
Enrollment: 309 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 12
States / cities: Gilbert, Arizona • Castro Valley, California • Sacramento, California + 9 more

Conditions: Knee Osteoarthritis
Interventions: canakinumab, LNA043, Placebo to canakinumab; Biological · Other
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 40 Years to 80 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 5
States / cities: La Mesa, California • Clearwater, Florida • Sunrise, Florida + 2 more

Conditions: Knee Osteoarthritis
Interventions: normal activities and clinical care, Concentric Focused Resistance Exercise, Eccentric Focused Resistance Exercise; Other
Lead sponsor: University of Florida; Other
Eligibility: 60 Years to 85 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Knee Osteoarthritis
Interventions: Laser Cell Therapy; Procedure
Lead sponsor: Endocellutions; Industry
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Steubenville, Ohio

Conditions: Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury, Defect of Articular Cartilage
Interventions: Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture; Biological · Other
Lead sponsor: ISTO Technologies, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2020
U.S. locations: 9
States / cities: Los Angeles, California • Santa Monica, California • Chicago, Illinois + 5 more

Conditions: Articular Cartilage Disorder of Knee
Interventions: Radiofrequency-Based Debridement, Mechanical Debridement; Device
Lead sponsor: Christopher Kaeding; Other
Eligibility: 18 Years to 50 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: Plyometric Exercise; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 15 Years to 30 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Knee Osteoarthritis
Interventions: Medial Unloader Brace; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 40 Years to 75 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Knee Osteoarthritis
Interventions: Not listed
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 30 Years to 80 Years
Enrollment: 906 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Hallux Rigidus
Interventions: Hallux Rigidus Treatment; Procedure
Lead sponsor: John Femino; Other
Eligibility: 18 Years to 75 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Defect of Articular Cartilage, Osteochondritis Dissecans
Interventions: Microfracture, Cartilage Autograft Implantation System; Procedure · Device
Lead sponsor: DePuy Mitek; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 27
States / cities: Tucson, Arizona • Bentonville, Arkansas • Encinitas, California + 24 more

Conditions: Osteoarthritis, Tendinitis, Sports Injury, Degenerative Disc Disease, Degenerative Arthritis, Ligament Injury, Neuropathy, Pelvic Pain
Interventions: Umbilical Allograft; Other
Lead sponsor: R3 Stem Cell; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2030
U.S. locations: 1
States / cities: Encino, California

Conditions: Cartilage Loss, Microfracture
Interventions: Unloader Bracing, Non-Bracing; Device
Lead sponsor: Stanford University; Other
Eligibility: 15 Years to 40 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Defect of Articular Cartilage
Interventions: Hyalofast, Microfracture; Device · Procedure
Lead sponsor: Anika Therapeutics, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2026
U.S. locations: 18
States / cities: Tempe, Arizona • Los Angeles, California • San Diego, California + 14 more

Conditions: Articular Cartilage of the Femoral Condyle Between 2-6cm2
Interventions: Microfracture, NOVOCART 3D; Procedure · Biological
Lead sponsor: Aesculap Biologics, LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 233 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2027
U.S. locations: 30
States / cities: La Mesa, California • Los Angeles, California • Redwood City, California + 26 more

Conditions: Osteoarthritis, Knee
Interventions: Magnetic Resonance Imaging; Other
Lead sponsor: American College of Radiology; Other
Eligibility: 18 Years and older
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2008
U.S. locations: 5
States / cities: Hershey, Pennsylvania • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Knee Injuries, Joint Surface Knee Lesions
Interventions: Marketed Product - MP01, Other Surgical Treatments; Device · Procedure
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2034
U.S. locations: 6
States / cities: Parker, Colorado • Washington D.C., District of Columbia • Indianapolis, Indiana + 3 more

Conditions: Knee Osteoarthritis
Interventions: Euflexxa, Magnetic Resonance Imaging (MRI); Drug · Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Defect of Articular Cartilage, Osteochondral Lesion of Talus, Osteochondritis Dissecans
Interventions: DeNovo NT Natural Tissue Graft; Other
Lead sponsor: Zimmer Orthobiologics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 205 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2019
U.S. locations: 8
States / cities: Sacramento, California • Honolulu, Hawaii • Baltimore, Maryland + 5 more

Conditions: Malignant Neoplasm of Bone and Articular Cartilage, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Independent (Primary) Multiple Sites, Malignant Neoplasms of Lip Oral Cavity and Pharynx, Malignant Neoplasm of Male Genital Organs, Malignant Neoplasms of Mesothelial and Soft Tissue, Malignant Neoplasm of Respiratory and Intrathoracic Organ Carcinoma, Malignant Neoplasms of Thyroid and Other Endocrine Glands, Malignant Neoplasms of Urinary Tract, Melanoma and Other Malignant Neoplasms of Skin
Interventions: Gemcitabine; Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 12 Years to 50 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Articular Cartilage
Interventions: Carticel (autologous cultured chondrocyte) implantation; Biological
Lead sponsor: Vericel Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2005
U.S. locations: 25
States / cities: Los Angeles, California • San Diego, California • Santa Monica, California + 22 more

Search by objective public record fields.

Evaluation of the CR Plug (Allograft) for the Treatment of a Cartilage Injury in the Knee.

Longitudinal Evaluation of Hip Cartilage Degeneration: FAI

Randomized Evaluation of the Efficacy of Synvisc-One® for the Treatment of Patellofemoral Chondromalacia

A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle

A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)

Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover

Laser Cell Therapy for Knee Cartilage Repair

Neocartilage Implant to Treat Cartilage Lesions of the Knee

Radiofrequency-Based Debridement vs. Mechanical Debridement for the Treatment of Articular Cartilage Lesions

Anterior Cruciate Ligament Reconstruction and Plyometric Exercise

Effect of Knee Bracing on Improving Pain & Disability

The Knee Usual Care Evaluation Study

Synthetic Cartilage Implant Versus Interposition Arthroplasty in Hallux Rigidus Treatment: A Randomized Clinical Trial

Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration

Evaluation of Outcomes With Umbilical Cord Allograft for Musculoskeletal Conditions Musculoskeletal Conditions

Effects of Unloader Bracing in Clinical Outcome and Cartilage Physiology Following Microfracture of Chondral Defects

HyaloFAST Trial for Repair of Articular Cartilage in the Knee

NOVOCART®3D for Treatment of Articular Cartilage of the Knee

MRI Markers of Cartilage Damage in Knee With Osteoarthritis

Knee Cartilage Repair Registry

To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection

DeNovo NT Ankle LDC Study

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Study of the Treatment of Articular Repair (STAR)