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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Bicuspid Aortic Valve (BAV) Clear all
Active, not recruiting No phase listed Observational

Pathogenetic Basis of Aortopathy and Aortic Valve Disease

NCT03440697
View directory record Official record
Conditions
Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease, Thoracic Aortic Dissection, Thoracic Aortic Rupture, Ascending Aortic Disease, Descending Aortic Disease, Ascending Aortic Aneurysm, Descending Aortic Aneurysm, Marfan Syndrome, Loeys-Dietz Syndrome, Vascular Ehlers-Danlos Syndrome, Shprintzen-Goldberg Syndrome, Turner Syndrome, PHACE Syndrome, Autosomal Recessive Cutis Laxa, Congenital Contractural Arachnodactyly, Arterial Tortuosity Syndrome, Bicuspid Aortic Valve-Associated Aortopathy, Bicuspid Aortic Valve, Familial Thoracic Aortic Aneurysm and Aortic Dissection
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2030
U.S. locations
2
States / cities
Atlanta, Georgia • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Completed No phase listed Observational

A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease

NCT01194362
View directory record Official record
Conditions
Aortic Valve Disease
Interventions
Not listed
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2022
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Cardiovascular Health Improvement Project

NCT02306200
View directory record Official record
Conditions
Aortic Aneurysm, Aortic Dissection, Bicuspid Aortic Valve (BAV), Heart Failure, Cardiovascular Diseases
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
Not listed
Enrollment
15,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2053
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations

NCT02889835
View directory record Official record
Conditions
Dental Caries
Interventions
Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Jun 25, 2026, 10:09 PM EDT
Recruiting Not applicable Interventional

Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial

NCT06817148
View directory record Official record
Conditions
Aortic Valve Stenosis, Bicuspid Aortic Valve
Interventions
transcatheter aortic valve replacement (TAVR), surgical aortic valve replacement (SAVR)
Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
50 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2037
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Jun 25, 2026, 10:09 PM EDT
Recruiting No phase listed Observational

Prospective 4D CTA of BAV Competence

NCT04645862
View directory record Official record
Conditions
Bicuspid
Interventions
CT scans
Diagnostic Test
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Completed Not applicable Interventional Results available

Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth

NCT01369108
View directory record Official record
Conditions
Dental Caries
Interventions
Flowable composite, Conventional composite restorative
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Jun 25, 2026, 10:09 PM EDT
Completed No phase listed Observational

Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve Disease

NCT02806310
View directory record Official record
Conditions
Aortic Valve Disease
Interventions
Blood draw
Other
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Jun 25, 2026, 10:09 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Identification of Genetic Causes of Calcific Aortic Valve Disease

NCT04149600
View directory record Official record
Conditions
Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency
Interventions
Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
Procedure
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
20 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Bicuspid Aortic Valve (BAV) Registry

NCT01756222
View directory record Official record
Conditions
Bicuspid Aortic Valve
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2040
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 15, 2025 · Synced Jun 25, 2026, 10:09 PM EDT
Completed No phase listed Observational

Bicuspid Valve Aortopathy Feasibility Study

NCT01920815
View directory record Official record
Conditions
Bicuspid Aortic Valve
Interventions
No interventions
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 90 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
6
States / cities
Los Angeles, California • Denver, Colorado • Atlanta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Jun 25, 2026, 10:09 PM EDT
Completed No phase listed Observational

National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

NCT01322165
View directory record Official record
Conditions
Marfan Syndrome, Turner Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome, FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation, Bicuspid Aortic Valve Without Known Family History, Bicuspid Aortic Valve With Family History, Bicuspid Aortic Valve With Coarctation, Familial Thoracic Aortic Aneurysm and Dissections, Shprintzen-Goldberg Syndrome, Other Aneur/Diss of Thoracic Aorta Not Due to Trauma, <50yo, Other Congenital Heart Disease
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Enrollment
3,706 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
7
States / cities
Honolulu, Hawaii • Baltimore, Maryland • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Dec 19, 2016 · Synced Jun 25, 2026, 10:09 PM EDT
Terminated Not applicable Interventional Results available

The Effect of Losartan in Bicuspid Aortic Valve Patients

NCT01390181
View directory record Official record
Conditions
Bicuspid Aortic Valve, Thoracic Aortic Aneurysm
Interventions
Cozaar
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 13, 2017 · Synced Jun 25, 2026, 10:09 PM EDT
Completed Not applicable Interventional Results available

Progel Vascular Sealant

NCT01959503
View directory record Official record
Conditions
Aortic Valve Stenosis, Aneurysm of Ascending Aorta, Aortic Valve Disorder, Bicuspid Valve Disorder
Interventions
Progel Vascular Sealant, Gelfoam Plus
Device
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
19
States / cities
Los Angeles, California • Aurora, Colorado • Gainesville, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2017 · Synced Jun 25, 2026, 10:09 PM EDT
Active, not recruiting Not applicable Interventional Results available

Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

NCT03635424
View directory record Official record
Conditions
Bicuspid Aortic Valve
Interventions
Medtronic TAVR Systems
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
60 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
25
States / cities
Phoenix, Arizona • La Jolla, California • Thousand Oaks, California + 21 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Identification of Genetic Causes of Bicuspid Aortic Valve Disease

NCT01026571
View directory record Official record
Conditions
Bicuspid Aortic Valve
Interventions
Not listed
Lead sponsor
Boston University
Other
Eligibility
14 Years to 80 Years
Enrollment
11,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Abnormal 3-D MRI Flow Patterns in Adolescents Patients With Bicuspid Aortic Valve

NCT00412386
View directory record Official record
Conditions
Congenital Heart Disease, Bicuspid Aortic Valve
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
10 Years to 18 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 2, 2013 · Synced Jun 25, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites

NCT03570333
View directory record Official record
Conditions
Gingival Recession, Lack of Keratinized Gingiva (Disorder)
Interventions
progenitor potential of Gingival Mesenchymal cells
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jun 25, 2026, 10:09 PM EDT
Completed No phase listed Observational

Genetic Risks for Bicuspid Aortic Valve Disease

NCT01823432
View directory record Official record
Conditions
Bicuspid Aortic Valve, Unicuspid Aortic Valve
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
454 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 20, 2022 · Synced Jun 25, 2026, 10:09 PM EDT
Not yet recruiting Not applicable Interventional

TAVR vs SAVR in Severe Bicuspid Aortic Stenosis

NCT07413965
View directory record Official record
Conditions
Bicuspid Aortic Valve Disease
Interventions
Transcatheter Aortic Valve Replacement, the open chest surgery to replace the aortic valve
Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
50 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2040
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Active, not recruiting No phase listed Observational

International Bicuspid Aortic Valve Consortium (BAVCon)

NCT01980797
View directory record Official record
Conditions
Bicuspid Aortic Valve Disease, Thoracic Aortic Disease in Patients With a Bicuspid Aortic Valve
Interventions
Not listed
Lead sponsor
Boston University
Other
Eligibility
8 Years to 90 Years
Enrollment
6,464 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2028
U.S. locations
5
States / cities
Boston, Massachusetts • Ann Arbor, Michigan • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jun 25, 2026, 10:09 PM EDT
Recruiting No phase listed Observational

Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry

NCT03836521
View directory record Official record
Conditions
Bicuspid Aortic Valve
Interventions
Transcatheter aortic valve replacement
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
19 Years to 129 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2019 · Synced Jun 25, 2026, 10:09 PM EDT