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ClinicalTrials.gov public records Last synced Sep 28, 2026, 1:54 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Cancer Lung Screening Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Gain-framed Messages and NRT for Lung Cancer Screening Patients

NCT03069924
View directory record Official record
Conditions
Lung Cancer Screening, Smoking Cessation
Interventions
Gain-framed messaging, Unframed messaging materials
Behavioral · Combination Product
Lead sponsor
Medical University of South Carolina
Other
Eligibility
50 Years and older
Enrollment
367 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
2
States / cities
New Haven, Connecticut • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 28, 2026, 1:54 AM EDT
Recruiting Not applicable Interventional

CHAMP Lung Cancer Screening Program

NCT07572773
View directory record Official record
Conditions
Lung Cancer, Early Lung Cancer Detection
Interventions
DELFI Diagnostics FirstLook Lung Cancer Screening Blood Test, Low-Does CT Scan
Diagnostic Test
Lead sponsor
Jill Kolesar
Other
Eligibility
50 Years to 77 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Iowa City, Iowa • Waterloo, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Recruiting Not applicable Interventional

Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

NCT07711691
View directory record Official record
Conditions
Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer
Interventions
Empower LCS, Call+ Telephone Navigation, Usual Care, Education
Behavioral · Other
Lead sponsor
University of California, Irvine
Other
Eligibility
50 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
57
States / cities
Anaheim, California • Costa Mesa, California • Irvine, California + 27 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Lung EpiCheck Biomarkers Development Study

NCT06245876
View directory record Official record
Conditions
Lung Cancer
Interventions
Blood collection
Other
Lead sponsor
Nucleix Ltd.
Industry
Eligibility
20 Years to 80 Years
Enrollment
6,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
6
States / cities
Miami, Florida • Panama City, Florida • Shreveport, Louisiana + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2024 · Synced Sep 28, 2026, 1:54 AM EDT
Not listed No phase listed Observational

Diagnostic Performance of Small RNA Blood Test in Patients Undergoing Follow-up Imaging After Positive Low Dose CT Screening for Cancer of the Lung

NCT05987189
View directory record Official record
Conditions
Lung Cancer
Interventions
miLungDx
Diagnostic Test
Lead sponsor
Hummingbird Diagnostics
Industry
Eligibility
50 Years to 80 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
8
States / cities
Atlanta, Georgia • Boston, Massachusetts • Detroit, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2024 · Synced Sep 28, 2026, 1:54 AM EDT
Terminated Not applicable Interventional

Culturally Tailored Educational Video to Promote Lung Cancer Screening in Vulnerable Communities

NCT06010355
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Lung Carcinoma
Interventions
Discussion, Media Intervention, Interview, Test
Procedure · Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Active, not recruiting Not applicable Interventional Results available

Screening for Lung Cancer in Older Patients (PLCO Screening Trial)

NCT01696968
View directory record Official record
Conditions
Lung Carcinoma
Interventions
Screening Questionnaire Administration, X-Ray Imaging
Other · Procedure
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
55 Years to 74 Years
Enrollment
154,901 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Terminated No phase listed Observational

This SCR-103 Protocol Will Permit Sites to Proactively Assess TAA, HLA and HPV-16 Status in Patients With Selected Solid Tumors to Determine Suitability for Repertoire Immune Medicines Treatment Protocols.

NCT05061940
View directory record Official record
Conditions
Head and Neck Cancer, Melanoma, HPV-Related Malignancy, HPV-Related Carcinoma, HPV-Related Cervical Carcinoma, HPV Positive Oropharyngeal Squamous Cell Carcinoma, Lung Cancer, Nonsmall Cell, Melanoma (Skin)
Interventions
Tumor Profiling
Diagnostic Test
Lead sponsor
Repertoire Immune Medicines
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Scottsdale, Arizona • Ann Arbor, Michigan • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 5, 2022 · Synced Sep 28, 2026, 1:54 AM EDT
Completed No phase listed Observational

CT Scans in Screening for Lung Cancer in Current and Former Smokers

NCT00625690
View directory record Official record
Conditions
Lung Cancer
Interventions
questionnaire administration, computed tomography, evaluation of cancer risk factors, study of high risk factors
Other · Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 120 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Sep 28, 2026, 1:54 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Evaluating the Impact of Centralized Interventions on Lung Cancer Screening Adherence in Community Settings, ACCELL Trial

NCT06324110
View directory record Official record
Conditions
Lung Carcinoma
Interventions
Electronic Health Record Review, Interview, Patient Navigation
Other · Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
6,772 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Completed No phase listed Observational Results available

Facilitators and Barriers to Cancer Screening: Stakeholder Perspectives on Implementation

NCT04683744
View directory record Official record
Conditions
Colorectal Cancer Screening
Interventions
Semi-structured interviews-Patients, Semi-structured interviews-Health system
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Sep 28, 2026, 1:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Blood Sample Collection in Subjects Participating in a Lung Cancer Screening Program

NCT03628638
View directory record Official record
Conditions
Healthy
Interventions
Blood Sample Collection
Other
Lead sponsor
Exact Sciences Corporation
Industry
Eligibility
50 Years and older
Enrollment
1,718 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
31
States / cities
Birmingham, Alabama • Peoria, Arizona • Springdale, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2021 · Synced Sep 28, 2026, 1:54 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

The Lung Screening, Tobacco and Health Project

NCT03200236
View directory record Official record
Conditions
Smoking, Tobacco, Tobacco-Related Carcinoma, Tobacco Use, Lung Cancer Screening
Interventions
Intensive Telephone Counseling (8 sessions) with nicotine replacement, Usual Care: Telephone counseling (3 sessions) with nicotine replacement
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
50 Years to 80 Years
Enrollment
1,114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
7
States / cities
Washington D.C., District of Columbia • Miami, Florida • Moline, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Sep 28, 2026, 1:54 AM EDT
Enrolling by invitation Not applicable Interventional

Centralized Lung Cancer Screening Engagement in At-Risk Populations

NCT07216144
View directory record Official record
Conditions
Lung Cancer Screening
Interventions
Centralized patient outreach for lung cancer screening
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 80 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 28, 2026, 1:54 AM EDT
Enrolling by invitation Not applicable Interventional

Personalizing Veterans' Lung Cancer Screening and Diagnosis

NCT07838519
View directory record Official record
Conditions
Lung Cancer Screening, Military Service-related Environmental and Occupational Exposures, Cancer Survivor, Family History of Lung Cancer, COPD, Burn Pit Exposure, Agent Orange Exposure, Radiation Exposure, Asbestos Exposure, Lung Neoplasm
Interventions
Low-dose computed tomography
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 80 Years
Enrollment
1,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
7
States / cities
Aurora, Colorado • Chicago, Illinois • Louisville, Kentucky + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer

NCT03059940
View directory record Official record
Conditions
Smoking Cessation
Interventions
Questionnaires, Low Dose Computed Tomography Scan, Shared Decision Making + Video, Cessation Counseling, Quitline, Pharmacotherapy Discussion, Nicotine Patch, Anti-Smoking Drug, Tobacco Treatment Program, Carbon Monoxide (CO) Level Test
Behavioral · Procedure · Other + 1 more
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
50 Years and older
Enrollment
630 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Active, not recruiting Phase 2 Interventional Results available

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

NCT03155620
View directory record Official record
Conditions
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Non-Hodgkin Lymphoma, Ann Arbor Stage IV Non-Hodgkin Lymphoma, Histiocytic Sarcoma, Juvenile Xanthogranuloma, Langerhans Cell Histiocytosis, Malignant Glioma, Recurrent Childhood Rhabdomyosarcoma, Recurrent Ependymoma, Recurrent Ewing Sarcoma, Recurrent Glioma, Recurrent Hepatoblastoma, Recurrent Langerhans Cell Histiocytosis, Recurrent Malignant Germ Cell Tumor, Recurrent Malignant Solid Neoplasm, Recurrent Medulloblastoma, Recurrent Neuroblastoma, Recurrent Non-Hodgkin Lymphoma, Recurrent Osteosarcoma, Recurrent Peripheral Primitive Neuroectodermal Tumor, Recurrent Primary Central Nervous System Neoplasm, Recurrent Rhabdoid Tumor, Recurrent Soft Tissue Sarcoma, Refractory Ewing Sarcoma, Refractory Glioma, Refractory Hepatoblastoma, Refractory Langerhans Cell Histiocytosis, Refractory Malignant Germ Cell Tumor, Refractory Malignant Solid Neoplasm, Refractory Medulloblastoma, Refractory Neuroblastoma, Refractory Non-Hodgkin Lymphoma, Refractory Osteosarcoma, Refractory Peripheral Primitive Neuroectodermal Tumor, Refractory Primary Central Nervous System Neoplasm, Refractory Rhabdoid Tumor, Refractory Rhabdomyosarcoma, Rhabdoid Tumor, Stage III Osteosarcoma AJCC v7, Stage III Soft Tissue Sarcoma AJCC v7, Stage IV Osteosarcoma AJCC v7, Stage IV Soft Tissue Sarcoma AJCC v7, Stage IVA Osteosarcoma AJCC v7, Stage IVB Osteosarcoma AJCC v7, Wilms Tumor
Interventions
Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan, Computed Tomography, Ensartinib, Erdafitinib, Ivosidenib, Laboratory Biomarker Analysis, Larotrectinib Sulfate, Magnetic Resonance Imaging, Mutation Carrier Screening, Olaparib, Palbociclib, Pharmacological Study, Positron Emission Tomography, Radionuclide Imaging, Samotolisib, Selpercatinib, Selumetinib Sulfate, Tazemetostat, Tipifarnib, Ulixertinib, Vemurafenib, X-Ray Imaging
Procedure · Drug · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
12 Months to 21 Years
Enrollment
1,377 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
168
States / cities
Birmingham, Alabama • Anchorage, Alaska • Mesa, Arizona + 126 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Not yet recruiting No phase listed Observational

Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization

NCT07768046
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
Interventions
Multiparametric chest MRI with diffusion-weighted imaging
Diagnostic Test
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2032
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Enrolling by invitation Not applicable Interventional

Facilitation of Information eXchange for Shared Decision Making for Lung Cancer Screening

NCT07517692
View directory record Official record
Conditions
Lung Cancer Screening
Interventions
FIX-SDM, Usual Care
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
50 Years to 77 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Temple Health Chest Initiative (THCI 2.0)

NCT06933758
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
Determine COPD prevalence utilizing spirometry along with CT scans and symptom assessments in the THCI lung cancer screening populatio
Diagnostic Test
Lead sponsor
Temple University
Other
Eligibility
50 Years to 80 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Sep 28, 2026, 1:54 AM EDT
Not listed No phase listed Observational

Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

NCT04712877
View directory record Official record
Conditions
NSCLC
Interventions
ctDNA, tumor NGS
Diagnostic Test
Lead sponsor
Lung Cancer Mutation Consortium
Network
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
21
States / cities
Davis, California • Los Angeles, California • Orange, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Sep 28, 2026, 1:54 AM EDT
Completed Not applicable Interventional Results available

The MyLungHealth Study Protocol: Engaging Patients to Enable Interoperable Lung Cancer Decision Support at Scale

NCT06338592
View directory record Official record
Conditions
Lung Cancer, Lung Neoplasms/Diagnosis
Interventions
MyLungHealth, DecisionPrecision+
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
50 Years to 79 Years
Enrollment
31,303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
New York, New York • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

An Educational Intervention (Lung Toolkit) for Improving Knowledge About Lung Cancer and Screening Among American Indian and Alaskan Native Cigarette Smokers, Lung PATHS Trial

NCT07615764
View directory record Official record
Conditions
Lung Carcinoma
Interventions
Educational Intervention, Interview, Questionnaire Administration
Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
50 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 28, 2026, 1:54 AM EDT
Recruiting Not applicable Interventional

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

NCT04949464
View directory record Official record
Conditions
HIV Infection, Tobacco-Related Carcinoma
Interventions
Computed Tomography, Smoking Cessation Intervention
Procedure · Behavioral
Lead sponsor
AIDS Malignancy Consortium
Network
Eligibility
45 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
11
States / cities
La Jolla, California • Washington D.C., District of Columbia • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 28, 2026, 1:54 AM EDT