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ClinicalTrials.gov public records Last synced Jul 21, 2026, 9:31 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cardiopulmonary Bypass Surgery Clear all
No Longer Available No phase listed Expanded access

Aprotinin US Special Access Protocol

NCT00611845
View directory record Official record
Conditions
Postoperative Hemorrhage
Interventions
Aprotinin (Trasylol, BAYA0128)
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
17
States / cities
Decatur, Alabama • Glendale, California • Pismo Beach, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2014 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Delayed Rewarming for Neuroprotection in Infants Following Cardiopulmonary Bypass Surgery

NCT03036072
View directory record Official record
Conditions
Post-Op Complication
Interventions
Strict normothermia, Delayed Rewarming
Other · Device
Lead sponsor
Alexa Craig
Other
Eligibility
Up to 6 Months
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Jul 21, 2026, 9:31 PM EDT
Completed No phase listed Observational

Risk of Developing Antibodies to Heparin-PF4 After Heart Surgery

NCT00237328
View directory record Official record
Conditions
Thrombosis
Interventions
Heparin
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
1,015 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
4
States / cities
Rochester, Minnesota • Chapel Hill, North Carolina • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2013 · Synced Jul 21, 2026, 9:31 PM EDT
Completed No phase listed Observational

Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta.

NCT00405093
View directory record Official record
Conditions
Circulatory Arrest
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
Not listed
Enrollment
1,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 18, 2017 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 2 Interventional Results available

A Dose-ranging Safety and Efficacy Study of Ecallantide to Reduce Surgical Blood Loss Volume

NCT00816023
View directory record Official record
Conditions
Bloodloss, Surgical Procedures, Operative
Interventions
ecallantide, placebo
Drug
Lead sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
18 Years to 85 Years
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
21
States / cities
Birmingham, Alabama • Montgomery, Alabama • Aurora, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2015 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 2 Interventional Results available

VentaProst Versus Conventionally-Administered Aerosolized Epoprostenol in Patients Undergoing Cardiac Surgery With CPB

NCT03122730
View directory record Official record
Conditions
Pulmonary Hypertension
Interventions
VentaProst
Combination Product
Lead sponsor
Aerogen Pharma Limited
Industry
Eligibility
18 Years to 75 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
3
States / cities
Stanford, California • Chicago, Illinois • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 4 Interventional

Efficacy of Pathogen Inactivation Strategies for Platelet Transfusion

NCT06535360
View directory record Official record
Conditions
Cardiopulmonary Bypass Surgery
Interventions
Platelet transfusion
Biological
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Jul 21, 2026, 9:31 PM EDT
Recruiting No phase listed Observational

Optimizing Pulsatility During Cardiopulmonary Bypass

NCT05344573
View directory record Official record
Conditions
Endothelial Dysfunction, Acute Kidney Injury
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 70 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery

NCT01245595
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Aminophylline, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
1 Day to 18 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Jul 21, 2026, 9:31 PM EDT
Withdrawn Phase 1 Interventional

Nitric Oxide During CPB to Reduce AKI in Neonates

NCT03946462
View directory record Official record
Conditions
Congenital Heart Disease, Acute Kidney Injury
Interventions
NO gas delivered during cardiac surgery, placebo gas delivered during cardiac surgery
Drug · Other
Lead sponsor
Fabio Savorgnan
Other
Eligibility
Up to 30 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 30, 2021 · Synced Jul 21, 2026, 9:31 PM EDT
Completed No phase listed Observational

Aprotinin in Neonates Undergoing Cardiopulmonary Bypass

NCT00469742
View directory record Official record
Conditions
Cardiopulmonary Bypass, Congenital Defects, Hemostasis
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
Up to 1 Month
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 15, 2012 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 2Phase 3 Interventional

Cylexin for Reduction of Reperfusion Injury in Infant Heart Surgery

NCT00226369
View directory record Official record
Conditions
Congenital Heart Defects
Interventions
CY-1503
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 45 Days
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 11, 2010 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 2Phase 3 Interventional

DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)

NCT04709705
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Human platelets
Biological
Lead sponsor
Cellphire Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
16
States / cities
Birmingham, Alabama • Aurora, Colorado • Washington D.C., District of Columbia + 12 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 3 Interventional Results available

Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass

NCT02025621
View directory record Official record
Conditions
Coronary Artery Bypass Grafting, Mitral Valve Surgery, Low Cardiac Output Syndrome
Interventions
Levosimendan, Placebo
Drug
Lead sponsor
Tenax Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
882 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
49
States / cities
Burlington, Alabama • Huntsville, Alabama • Sacramento, California + 41 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2018 · Synced Jul 21, 2026, 9:31 PM EDT
Not listed Phase 2 Interventional

Study to Prevent Acute Kidney Injury After Cardiac Surgery Involving Cardiopulmonary Bypass

NCT02771509
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
ANG-3777, Placebo
Drug
Lead sponsor
Angion Biomedica Corp
Industry
Eligibility
18 Years and older
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
23
States / cities
Los Angeles, California • Palo Alto, California • San Diego, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2021 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Early Phase 1 Interventional Results available

The Effects of Modified Ultrafiltration on Vancomycin Levels During Cardiopulmonary Bypass in Cardiac Surgery

NCT02051595
View directory record Official record
Conditions
Infection
Interventions
Vancomycin concentrations
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 12, 2019 · Synced Jul 21, 2026, 9:31 PM EDT
Terminated Phase 3 Interventional

Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart Surgery

NCT00458276
View directory record Official record
Conditions
Heart Diseases, Hypertension, Pulmonary
Interventions
tezosentan, placebo
Drug
Lead sponsor
Idorsia Pharmaceuticals Ltd.
Industry
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
9
States / cities
Stanford, California • New York, New York • Durham, North Carolina + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2018 · Synced Jul 21, 2026, 9:31 PM EDT
Terminated Phase 2 Interventional

The Use of HEMOBAG to Salvage Blood After Cardiac Surgery

NCT00176657
View directory record Official record
Conditions
Cardiopulmonary Bypass, Cardiac Diseases
Interventions
HEMOBAG Assessment
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 30, 2007 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional

Seattle Cardiorenal Remote Ischemic Preconditioning Trial

NCT01260259
View directory record Official record
Conditions
Congenital Heart Disease, Cardiopulmonary Bypass, Myocardial Injury, Acute Kidney Injury, Acute Lung Injury
Interventions
RIPC, Control
Procedure
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Up to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 17, 2013 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 1 Interventional

Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery

NCT01839812
View directory record Official record
Conditions
Adrenal Cortex Diseases, Infant Morbidity
Interventions
Cosyntropin
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
Up to 365 Days
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 15, 2014 · Synced Jul 21, 2026, 9:31 PM EDT
Completed No phase listed Observational

Impact of Pre-operative Steroids on Adrenal Insufficiency

NCT02956707
View directory record Official record
Conditions
Adrenal Insufficiency Neonatal
Interventions
No pre-operative steroids
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
1 Day to 60 Days
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Jul 21, 2026, 9:31 PM EDT
Completed No phase listed Observational Results available

Hemosonics- VCU Cardiac Surgery Clinical Study

NCT02392247
View directory record Official record
Conditions
Cardiopulmonary Bypass
Interventions
Coagulation function
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 89 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Jul 21, 2026, 9:31 PM EDT
Recruiting Phase 3 Interventional

NO During CPB in Neonates to Reduce Risk of AKI

NCT04216927
View directory record Official record
Conditions
AKI, CHD - Congenital Heart Disease, Surgery
Interventions
Nitric Oxide, Oxygen
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Day to 31 Days
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 21, 2026, 9:31 PM EDT
Terminated Phase 2 Interventional Results available

Safety & Efficacy of BCT197 in Patients Undergoing Cardiac Surgery

NCT01336959
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
BCT197 Part A, Placebo, BCT197 Part B
Drug
Lead sponsor
Mereo BioPharma
Industry
Eligibility
18 Years to 85 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
6
States / cities
Orange, California • Saginaw, Michigan • Lincoln, Nebraska + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2020 · Synced Jul 21, 2026, 9:31 PM EDT