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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chatbot Clear all
Completed Not applicable Interventional

Chatbot for Depression, Anxiety, and Eating Disorders

NCT06013137
View directory record Official record
Conditions
Depression, Anxiety, Eating Disorders
Interventions
Therabot
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Staying Healthy With Follow-up Care: A Mobile Chatbot Feasibility Study for AYA Cancer Survivors

NCT05863702
View directory record Official record
Conditions
Survivorship
Interventions
Penny
Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Chatbot Intervention for Reducing HPV Vaccine Hesitancy

NCT05959564
View directory record Official record
Conditions
Cervical Cancer, Anal Cancer, Penile Cancer
Interventions
Personalized Chatbot Intervention, Non-Personalized Chatbot Intervention, No Chatbot Control
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years and older
Enrollment
456 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 20, 2024 · Synced Jul 23, 2026, 10:06 AM EDT
Not yet recruiting Not applicable Interventional

Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial

NCT07223736
View directory record Official record
Conditions
Pelvic Floor Disorder, Loneliness, Postpartum, Mental Health, Depression, Peritraumatic Distress, Women, Artificial Intelligence (AI), Chatbot
Interventions
Generative artificial intelligence (genAI) postpartum chatbot, Standard of Care (SOC)
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Brief Negotiation Interview Chatbot to Improve Buprenorphine Engagement Among Justice-Involved Individuals

NCT04982627
View directory record Official record
Conditions
Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe, Criminal Behavior
Interventions
BNI Chatbot, OUD Education & Treatment Resources
Behavioral
Lead sponsor
Center for Progressive Recovery, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

Supporting Care Partners' Well-Being With Artificial Intelligence (AI) Chatbots

NCT07145723
View directory record Official record
Conditions
Caregivers
Interventions
Earkick app
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Not yet recruiting Not applicable Interventional

Prenatal Genetics Chatbot Trial: Prenatal GENEie

NCT07077707
View directory record Official record
Conditions
Genetic Counseling
Interventions
Prenatal GENEie Chatbot, In-person genetic counseling
Other
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
1,470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Jul 23, 2026, 10:06 AM EDT
Recruiting Phase 2 Interventional

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

NCT05864534
View directory record Official record
Conditions
Newly Diagnosed Glioblastoma, Glioblastoma, Isocitric Dehydrogenase (IDH)-Wildtype, Gliosarcoma, Glioblastoma Multiforme
Interventions
Balstilimab, Botensilimab, Liposomal Doxorubicin, Sonocloud-9 (SC-9)
Drug · Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Conversations With AI Chatbots Increase Short-Term Vaccine Intentions But Do Not Outperform Standard Public Health Messaging

NCT07132125
View directory record Official record
Conditions
HPV Vaccination Intent
Interventions
Default-style LLM chatbot, Conversational-style LLM chatbot, Public health informational materials
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
930 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Jul 23, 2026, 10:06 AM EDT
Not yet recruiting Not applicable Interventional

SAFE.AI: Developing and Testing an AI-based Hybrid Chatbot for Financial Empowerment in Rural Cancer Care

NCT07410689
View directory record Official record
Conditions
Cancer, Financial Toxicity
Interventions
Rule-Based Chatbot, Hybrid Chatbot
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Recruiting Phase 1 Interventional

Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors

NCT05994209
View directory record Official record
Conditions
Nicotine Vaping, Nicotine Use Disorder
Interventions
quitSTART Mobile Application, Chatbot Feature in quitSTART Mobile Application
Device · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
15 Years to 25 Years
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Recruiting Phase 2 Interventional

Eating Disorder Chatbot Optimization

NCT07218302
View directory record Official record
Conditions
Eating Disorders
Interventions
Digital Chatbot Program
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

Effects of Targeted Lower Extremity Joint Training on Multiple Sclerosis (MS) Gait Abnormalities

NCT00906737
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Ankle-bot, Conventional focused ankle therapy
Device · Other
Lead sponsor
Mount Sinai Rehabilitation Hospital
Other
Eligibility
25 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 8, 2014 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

Sleep Chatbot Intervention for Emerging Black/African American Adults

NCT05956886
View directory record Official record
Conditions
Sleep Deprivation, Insomnia, Metabolic Syndrome
Interventions
sleep chatbot
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 25 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Trial of the First Conversational Agent for Smoking Cessation (QuitBot)

NCT03585231
View directory record Official record
Conditions
Smoking Cessation
Interventions
Immediate access to novel messaging program intervention, Immediate access to standard of care messaging program intervention, Delayed access to novel novel messaging program intervention
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
404 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 7, 2020 · Synced Jul 23, 2026, 10:06 AM EDT
Recruiting Not applicable Interventional

Developing an Artificial Intelligence (AI) Chatbot for Adolescents and Young Adults With Eating Disorders

NCT07237607
View directory record Official record
Conditions
Eating Disorders, Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder
Interventions
"Exp-ED" Digital Exposure-Therapy Chatbot app
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
12 Years to 26 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Not yet recruiting Not applicable Interventional

Improving Patient Understanding of Their Prostate Cancer Diagnosis Using AI

NCT07040501
View directory record Official record
Conditions
Prostate Cancer
Interventions
Chat GPT
Device
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
19 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional

A Chatbot To Support Substance Use Recovery

NCT06845878
View directory record Official record
Conditions
Opiate-Related Disorders, Opiate Substitution Treatment
Interventions
chatbot
Other
Lead sponsor
Dimagi Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

iWellness Study to Evaluate a Mental Health App for Students

NCT05234970
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Wysa, Harvard College App
Other
Lead sponsor
Harvard University
Other
Eligibility
18 Years and older
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Jul 23, 2026, 10:06 AM EDT
Not yet recruiting Not applicable Interventional

Feasibility and Acceptability of an LLM-based Chatbot for Family Caregivers: Evaluation Study

NCT07280650
View directory record Official record
Conditions
Caregivers
Interventions
LLM-based Chatbot
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

Patient Perceived Empathy of an AI Chatbot for Atrial Fibrillation Education

NCT06684457
View directory record Official record
Conditions
Atrial Fibrillation (AF)
Interventions
Atrial Fibrillation Education
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2025 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tracking Depression Symptoms With a Health Chatbot

NCT03990389
View directory record Official record
Conditions
Depression, Postpartum, Depression, Unipolar
Interventions
Chatbot Intervention
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Chicago, Illinois • Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Jul 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Results available

Feasibility and Acceptability of W-GenZD vs CBT-light Teletherapy for Adolescents Seeking Mental Health Services

NCT05372913
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Woebot for Adolescents (W-GenZD) Mobile Application, CBT-Lite Teletherapy Group
Device · Behavioral
Lead sponsor
Woebot Health
Industry
Eligibility
13 Years to 17 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Jul 23, 2026, 10:06 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

RCT of HeartBot in Women

NCT07416734
View directory record Official record
Conditions
Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke, Participants Should Have no Terminal Illness or Diagnosed Cognitive Impairment, Including Alzheimer's Disease, Participants Should Not be a Healthcare Professionals or Healthcare Trainees, Participants Should Not be Employed in the Healthcare Field, Participants Should Reside in the United States and be a University of California, San Francisco Health Patient, Participants Should Possess a Smartphone With an Active Data Plan or Access to Wi-Fi
Interventions
HeartBot II Program, Waitlist Control
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
25 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Jul 23, 2026, 10:06 AM EDT