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ClinicalTrials.gov public records Last synced Oct 20, 2026, 5:44 PM EDT

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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Crying Clear all
Completed Phase 3 Interventional

Safety Study of AVP-923 in the Treatment of IEED (Involuntary Emotional Expression Disorder) Also Known as Pseudobulbar Affect (Episodes of Uncontrolled Crying and/or Laughter)

NCT00056524
View directory record Official record
Conditions
Alzheimer's Disease, Stroke, Parkinson's Disease, Traumatic Brain Injury
Interventions
AVP-923
Drug
Lead sponsor
Avanir Pharmaceuticals
Industry
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
39
States / cities
Phoenix, Arizona • La Jolla, California • Los Angeles, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2016 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Not applicable Interventional

Does Style of Pre-sedation Instructions Improve Patient Outcomes in Ambulatory Anesthesia for Oral and Maxillofacial Surgery?

NCT06768021
View directory record Official record
Conditions
Anesthesia Outcomes, Anesthesia Complication, Anesthesia and Procedure Related Time Intervals, Anesthesia Recovery Period, Anesthesia, Intravenous, Anesthesia Induction
Interventions
Guided visualization and standardized pre-sedation instructions, Standardized pre-sedation instructions only
Behavioral
Lead sponsor
Alameda Health System
Other
Eligibility
8 Years to 70 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Oct 20, 2026, 5:44 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

An In-home Observational Study to Compare Infant Crying and Fussing Parameters Documented by the LENA Recorder With Those Documented Via Parental E-diaries

NCT03390348
View directory record Official record
Conditions
Crying, Fussy Infant (Baby)
Interventions
LENA Recorder
Device
Lead sponsor
Danone Asia Pacific Holdings Pte, Ltd.
Industry
Eligibility
Up to 15 Weeks
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 17, 2018 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Vibrating, Cold Device for Pediatric Intravenous (IV) Cannulation Pain Relief

NCT01394250
View directory record Official record
Conditions
Pain, Anxiety
Interventions
Buzzy, Topical Lidocaine 4% Cream
Device · Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
4 Years to 18 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 16, 2016 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sleep in SNOO Smart Sleeper Bassinet in Preterm Infants

NCT05711927
View directory record Official record
Conditions
Prematurity, Very Preterm Maturity of Infant
Interventions
SNOO Smart Sleeper, Traditional bassinet
Device
Lead sponsor
Columbia University
Other
Eligibility
1 Week to 12 Weeks
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

An Intervention to Decrease Infant Crying

NCT00796523
View directory record Official record
Conditions
Colic
Interventions
Happiest Baby videotape, control videotape
Behavioral
Lead sponsor
Riverside Methodist Hospital
Other
Eligibility
Up to 5 Days
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 24, 2008 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Not applicable Interventional

Measuring and Reducing Excessive Infant Crying

NCT01217658
View directory record Official record
Conditions
Infant Colic, Postpartum Depression
Interventions
The Happiest Baby on The Block, AAP Infant Colic counseling
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
3 Weeks to 5 Weeks
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 8, 2015 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Take 5 + Audio Clip Randomized Control Trial

NCT04608877
View directory record Official record
Conditions
Abuse, Child, Crying, Parent-Child Relations
Interventions
Take 5 and Audio Clip, Take 5 Only
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety and Effect of L. Reuteri on Biomarkers of Inflammation in Healthy Infants With Colic

NCT01849991
View directory record Official record
Conditions
Gastrointestinal, Colic
Interventions
Lactobacillus reuteri, Placebo
Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
3 Weeks to 3 Months
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 30, 2018 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of PURPLE Cry Intervention

NCT02227979
View directory record Official record
Conditions
Shaken Baby Syndrome, Crying, Trauma
Interventions
The Purple Cry Intervention, Control Intervention
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older · Male only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 8, 2016 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Phase 3 Interventional

Safety and Efficacy of AVP-923 for Pseudobulbar Affect in Multiple Sclerosis Patients

NCT00050232
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
AVP-923
Drug
Lead sponsor
Avanir Pharmaceuticals
Industry
Eligibility
18 Years to 68 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
20
States / cities
Phoenix, Arizona • Washington D.C., District of Columbia • Fort Lauderdale, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2016 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Phase 3 Interventional

Safety/Efficacy of AVP-923 in the Treatment of Emotional Lability (Uncontrolled Crying & Laughing) in Patients With ALS

NCT00021697
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
AVP-923
Drug
Lead sponsor
Avanir Pharmaceuticals
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
17
States / cities
Loma Linda, California • Los Angeles, California • San Francisco, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2016 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic

NCT01279265
View directory record Official record
Conditions
Colic, Inflammation
Interventions
Nutramigen with Enflora, Nutramigen A+
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
3 Weeks to 3 Months
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2015 · Synced Oct 20, 2026, 5:44 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Feeding Intervention for Infants With Crying

NCT01017991
View directory record Official record
Conditions
Crying
Interventions
Milk based infant formula with probiotic, Milk based infant formula
Other
Lead sponsor
Société des Produits Nestlé (SPN)
Industry
Eligibility
3 Weeks to 4 Months
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
9
States / cities
Bentonville, Arkansas • San Francisco, California • Washington D.C., District of Columbia + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 17, 2017 · Synced Oct 20, 2026, 5:44 PM EDT
Terminated Phase 4 Interventional Results available

Effectiveness, Safety, and Health-Related Outcomes of NUEDEXTA® in Nursing Home Patients With Pseudobulbar Affect (PBA)

NCT02496039
View directory record Official record
Conditions
Pseudobulbar Affect (Involuntary Laughing and/or Crying)
Interventions
NUEDEXTA®
Drug
Lead sponsor
Avanir Pharmaceuticals
Industry
Eligibility
18 Years to 90 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Miami, Florida • Centerville, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 3, 2017 · Synced Oct 20, 2026, 5:44 PM EDT
Completed Not applicable Interventional

Study to Evaluate the Efficacy of a Probiotic in Infantile Colic Symptoms Relief

NCT05432479
View directory record Official record
Conditions
Infantile Colic
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
The Archer-Daniels-Midland Company
Industry
Eligibility
3 Weeks to 12 Weeks
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 20, 2026, 5:44 PM EDT