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Showing 1–24 of 53 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Decompensation, Heart Clear all
Completed No phase listed Observational

Sleep Disordered Breathing in Acute Congestive Heart Failure

NCT03804827
View directory record Official record
Conditions
Obstructive Sleep Apnea, Heart Failure; With Decompensation
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 80 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Early Phase 1 Interventional

Treating Congestive Heart Failure Using a Device to Remove Cholesterol

NCT00510601
View directory record Official record
Conditions
Heart Decompensation
Interventions
Kaneka Liposorber
Device
Lead sponsor
Patrick Moriarty, MD, FACP, FACC
Other
Eligibility
18 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Sep 6, 2026, 4:51 PM EDT
Withdrawn Not applicable Interventional

Inpatient Mortality Prediction Algorithm Clinical Trial (IMPACT)

NCT03212534
View directory record Official record
Conditions
Decompensation, Heart, Decompensation; Heart, Congestive, Death
Interventions
Patient mortality prediction
Other
Lead sponsor
Dascena
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 23, 2021 · Synced Sep 6, 2026, 4:51 PM EDT
Completed No phase listed Observational

Dynamic Thoracic Impedance as a Marker for Heart Failure Decompensation

NCT02134379
View directory record Official record
Conditions
Heart Failure; With Decompensation
Interventions
Medtronic ICDs, CRT-Ds, and CRT-Ps
Device
Lead sponsor
Charles Porter, MD
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2016 · Synced Sep 6, 2026, 4:51 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable

NCT06763549
View directory record Official record
Conditions
Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure, HFrEF - Heart Failure with Reduced Ejection Fraction, HFpEF - Heart Failure with Preserved Ejection Fraction, Syncopation, Syncope, Ischemic Cardiovascular Disease, STEMI, STEMI (ST Elevation MI), Atrial Fibrillation (AF), Atrial Enlargement, LVF, Conduction Defect, Conduction Abnormalities, Heart Block, Valvular Diseases, Cardiac Output, Low, Stroke Volume, Stroke Volume Variation, Hyperkalemia, Hypercalcemia, Hypocalcemia, LV Dysfunction, QT Prolongation, Sudden Cardiac Death Due to Cardiac Arrhythmia, Ventricular Arrhythmia, Pacing, Pacing Induced Dyssynchrony, Silent Ischemia, Pericarditis, Sleep Related Breathing Disorder, RSA, Apnea, Obstructive, Cardiac Output Measurement, Respiratory Impedance, CRT And/or ICD, Infarction, Cardiomyopathies, Primary, Hypertrophy
Interventions
SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C, SUBPROTOCOL D, SUBPROTOCOL E, SUBPROTOCOL F, SUBPROTOCOL G, SUBPROTOCOL H
Device
Lead sponsor
Peerbridge Health, Inc
Industry
Eligibility
18 Years and older
Enrollment
15,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Sep 6, 2026, 4:51 PM EDT
Terminated Not applicable Interventional

Above-Knee-High Application of Lower Limb Compression and Its Impact on Clinical Outcome in Patients Hospitalized With Heart Failure Exacerbation.

NCT05467735
View directory record Official record
Conditions
Heart Failure; With Decompensation, Lower Extremity Edema, Heart Failure，Congestive
Interventions
Application of compression to bilateral lower extremities of patients using appropriately-sized elastic compression stockings.
Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Sep 6, 2026, 4:51 PM EDT
Completed No phase listed Observational

Evaluate Heart Failure Patients With Specially Designed Patient Adherence and Monitoring Software on Standard Mobile Devices

NCT01430936
View directory record Official record
Conditions
Cardiac Decompensation
Interventions
Not listed
Lead sponsor
Aventyn, Inc.
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Mineola, New York • Roslyn, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2012 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Phase 2 Interventional

Evaluation of the Effects of Carperitide in Patients With Congestive Heart Failure

NCT00259038
View directory record Official record
Conditions
Heart Failure, Congestive, Heart Decompensation, Left Ventricular Failure, Myocardiopathies, Systolic or Diastolic Left Ventricular Dysfunction
Interventions
Carperitide, Placebo
Drug
Lead sponsor
Daiichi Sankyo
Industry
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
30
States / cities
Huntsville, Alabama • Los Angeles, California • Orange, California + 25 more
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Sep 6, 2026, 4:51 PM EDT
Terminated Phase 2 Interventional

A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF)

NCT01064037
View directory record Official record
Conditions
Heart Failure, Heart Decompensation
Interventions
Cinaciguat (BAY58-2667), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
6
States / cities
Chicago, Illinois • Detroit, Michigan • Cincinnati, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Sep 6, 2026, 4:51 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Postoperative Respiratory Abnormalities

NCT04079829
View directory record Official record
Conditions
Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure, Acute Respiratory Failure With Hypoxia, Acute Respiratory Failure With Hypercapnia, Acute Respiratory Failure Post Surgical, Acute Respiratory Failure Postprocedural, Acute Respiratory Failure Following Trauma and Surgery, Acute Respiratory Failure Requiring Reintubation, Acute Respiratory Failure Post Traumatic, Acute Respiratory Decompensation, Shock, Shock, Septic, Shock, Cardiogenic, Acute Cardiac Failure, Multi Organ Failure, Acute Kidney Failure
Interventions
Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
Other
Lead sponsor
Efficacy Care R&D Ltd
Industry
Eligibility
18 Years to 90 Years
Enrollment
50,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Not applicable Interventional Results available

The Aortix CRS Pilot Study

NCT04145635
View directory record Official record
Conditions
Heart Failure; With Decompensation, Cardiorenal Syndrome, Cardio-Renal Syndrome, Heart Failure, Heart Failure，Congestive, Heart Failure, Systolic, Heart Failure, Diastolic
Interventions
Aortix System
Device
Lead sponsor
Procyrion
Industry
Eligibility
21 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
14
States / cities
Los Angeles, California • San Francisco, California • Denver, Colorado + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Sep 6, 2026, 4:51 PM EDT
Not listed No phase listed Observational

Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF or COPD

NCT05865184
View directory record Official record
Conditions
COPD, Chronic Obstructive Pulmonary Disease, COPD Exacerbation, CHF, Congestive Heart Failure
Interventions
Data collection
Other
Lead sponsor
Sensorum Health Inc.
Industry
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Neptune City, New Jersey
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Sep 6, 2026, 4:51 PM EDT
Completed No phase listed Observational

Evaluation of Multisensor Data in Heart Failure Patients With Implanted Devices

NCT01128166
View directory record Official record
Conditions
Heart Failure
Interventions
COGNIS CRT-D
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
975 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
81
States / cities
Anchorage, Alaska • Gilbert, Arizona • Little Rock, Arizona + 69 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2015 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy Study of Once and Twice Daily Doses of MCC-135 in Subjects With Congestive Heart Failure.

NCT00050076
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
MCC-135, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
53
States / cities
Phoenix, Arizona • Tucson, Arizona • Carmichael, California + 47 more
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Not applicable Interventional

ENABLE: CHF-PC (Comprehensive Heartcare For Patients and Caregivers)

NCT03177447
View directory record Official record
Conditions
Heart Failure, Congestive
Interventions
ENABLE CHF-PC
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
50 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Birmingham, Alabama • Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 26, 2020 · Synced Sep 6, 2026, 4:51 PM EDT
Terminated Not applicable Interventional Results available

Evaluation of Cardiac Compass With OptiVol in the Early Detection of Decompensation Events for Heart Failure

NCT00510198
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
Cardiac Compass with OptiVol Fluid Status Monitoring, Standard of Care alone (clinical assessment)
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
33
States / cities
Anchorage, Alaska • Little Rock, Arkansas • Berkeley, California + 30 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 6, 2026, 4:51 PM EDT
Terminated No phase listed Observational

Nanowear Heart Failure Management Multi-sensor Algorithm

NCT03719079
View directory record Official record
Conditions
Heart Failure
Interventions
SimpleSENSE
Device
Lead sponsor
Nanowear Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 6, 2026, 4:51 PM EDT
Recruiting Not applicable Interventional

Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis

NCT07230964
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Impedance Cardiography Upright/Supine Test
Device
Lead sponsor
Dermed Diagnostics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Phase 3 Interventional

Tezosentan in Acute Heart Failure

NCT00525707
View directory record Official record
Conditions
Acute Heart Failure, Acute Decompensation of Chronic Heart Failure, New Onset of Heart Failure
Interventions
tezosentan
Drug
Lead sponsor
Idorsia Pharmaceuticals Ltd.
Industry
Eligibility
18 Years and older
Enrollment
735 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
8
States / cities
Birmingham, Alabama • Palo Alto, California • Denver, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Phase 2 Interventional Results available

Phase IIb Safety and Efficacy Study of Different Oral Doses of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone

NCT01807221
View directory record Official record
Conditions
Heart Failure
Interventions
Finerenone (BAY94-8862), Placebo, Inspra (eplerenone)
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
1,066 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
10
States / cities
Birmingham, Alabama • La Jolla, California • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2021 · Synced Sep 6, 2026, 4:51 PM EDT
Terminated Phase 2 Interventional Results available

Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease

NCT02791906
View directory record Official record
Conditions
Renal Insufficiency, Chronic
Interventions
ISMN, Vitamin C
Drug · Dietary Supplement
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Phase 3 Interventional

Tezosentan in the Treatment of Acute Heart Failure

NCT00524433
View directory record Official record
Conditions
Acute Heart Failure, Acute Decompensation of Chronic Heart Failure, New Onset of Heart Failure
Interventions
tezosentan, placebo
Drug
Lead sponsor
Idorsia Pharmaceuticals Ltd.
Industry
Eligibility
18 Years and older
Enrollment
713 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
16
States / cities
Huntsville, Alabama • Los Angeles, California • Jacksonville, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Sep 6, 2026, 4:51 PM EDT
Completed Phase 3 Interventional Results available

A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure

NCT00475852
View directory record Official record
Conditions
Heart Decompensation
Interventions
Nesiritide, Placebo
Drug
Lead sponsor
Scios, Inc.
Industry
Eligibility
18 Years and older
Enrollment
7,141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
171
States / cities
Huntsville, Alabama • Mobile, Alabama • Anchorage, Alaska + 168 more
Source: ClinicalTrials.gov public record
Updated Mar 7, 2013 · Synced Sep 6, 2026, 4:51 PM EDT
Completed No phase listed Observational

Heart Sounds Registry

NCT03203629
View directory record Official record
Conditions
Heart Failure; With Decompensation
Interventions
Wearable Cardioverter Defibrillator (WCD)
Device
Lead sponsor
Zoll Medical Corporation
Industry
Eligibility
18 Years and older
Enrollment
705 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
17
States / cities
National City, California • Atlantis, Florida • Fort Lauderdale, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2021 · Synced Sep 6, 2026, 4:51 PM EDT