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ClinicalTrials.gov public records Last synced Oct 13, 2026, 5:51 PM EDT

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Showing 337–360 of 914 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Arthritis of Knee Clear all
Terminated Phase 3 Interventional Results available

Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)

NCT00704847
View directory record Official record
Conditions
Osteoarthritis
Interventions
Oral Salmon Calcitonin, Oral Salmon Calcitonin (Placebo)
Drug
Lead sponsor
Nordic Bioscience A/S
Industry
Eligibility
51 Years to 80 Years
Enrollment
1,030 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
6
States / cities
Tuscaloosa, Alabama • Sacramento, California • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 13, 2026, 5:51 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantitative Analysis Before and After a Single Session of Manual Physical Therapy

NCT04234282
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Deformity, Knee Pain Swelling, Muscle Weakness, Muscle Weakness Condition, Power
Interventions
Manual Physical Therapy
Procedure
Lead sponsor
Jennifer Moreno Clinic
Other
Eligibility
45 Years to 74 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Oct 13, 2026, 5:51 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain

NCT04989660
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Pain Chronic
Interventions
6% aqueous phenol, Isotonic saline
Drug
Lead sponsor
Kessler Foundation
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee

NCT00589979
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Lidoderm (Lidocaine 5% Patch), Placebo Patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
37 Years and older
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
20
States / cities
Paradise Valley, Arizona • Phoenix, Arizona • Milford, Connecticut + 16 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis (STRIDES)

NCT05603754
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Lorecivivint, Placebo
Drug
Lead sponsor
Biosplice Therapeutics, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
499 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
44
States / cities
Tucson, Arizona • Cerritos, California • La Mesa, California + 35 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 13, 2026, 5:51 PM EDT
Terminated Phase 4 Interventional Results available

Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.

NCT00484718
View directory record Official record
Conditions
Osteoarthritis
Interventions
celecoxib, Oxycodone, placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
40 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Oct 13, 2026, 5:51 PM EDT
Not yet recruiting Not applicable Interventional

Short-term and Intermediate-term Effects of Self-applied Joint Mobilization Versus Clinician-applied Joint Mobilization in Addition to Exercise in Patients With Knee Osteoarthritis: A Randomized Clinical Trial

NCT07020897
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Clinician-administered joint mobilization, Self-administered joint mobilization, Exercise-based physical therapy
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
45 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Allen, Texas • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 13, 2026, 5:51 PM EDT
Withdrawn Not applicable Interventional

Optetrak Posterior Stabilized Versus Optetrak Hi-Flex

NCT00808613
View directory record Official record
Conditions
Arthropathy of Knee, Arthritis and/or Post-traumatic Degenerative Problems
Interventions
Optetrak PS, Optetrak Hi-Flex
Device
Lead sponsor
Exactech
Industry
Eligibility
50 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Newport News, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Not applicable Interventional Results available

Staying Active With Arthritis: RCT of Physical Activity for Older Adults With Osteoarthritis and Hypertension

NCT01280903
View directory record Official record
Conditions
Osteoarthritis, Knee, Hypertension
Interventions
STAR Intervention, Attention-Control
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 13, 2026, 5:51 PM EDT
Terminated Phase 3 Interventional Results available

Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee

NCT03285646
View directory record Official record
Conditions
Chronic Low Back Pain, Osteoarthritis
Interventions
Fasinumab, Placebo
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
56
States / cities
Phoenix, Arizona • Tucson, Arizona • Anaheim, California + 47 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 13, 2026, 5:51 PM EDT
Not listed Not applicable Interventional

Intra-articular Adipose Tissue Injections for Osteoarthritis

NCT03242707
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Autologous adipose tissue injection, Hyaluronic Acid
Biological · Drug
Lead sponsor
University of Southern California
Other
Eligibility
45 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2019 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Not applicable Interventional Results available

Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee Arthroplasty

NCT04730271
View directory record Official record
Conditions
Osteo Arthritis Knee, Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Crosby, Minnesota • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 13, 2026, 5:51 PM EDT
Completed No phase listed Observational

Treatment and Duration Effect of Pentosan Polysulfate Sodium (PPS) in Participants With Knee Osteoarthritis Pain

NCT04814719
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Pentosan Polysulphate Sodium, Placebo (Sodium Chloride Injection, 0.9%)
Drug
Lead sponsor
Paradigm Biopharmaceuticals Ltd.
Industry
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Oct 13, 2026, 5:51 PM EDT
Not listed Not applicable Interventional

The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

NCT03014401
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Arthroscopic debridement with stem cell transplantation, Arthroscopic debridement only
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
35 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
3
States / cities
Santa Monica, California • Stanford, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Not applicable Interventional

Strengthening Exercise and Quadriceps Force During Walking

NCT01538407
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Strength Training
Other
Lead sponsor
Frederiksberg University Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 22, 2014 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis

NCT00108992
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Diclofenac, topical
Drug
Lead sponsor
Nuvo Research Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
22
States / cities
Mobile, Alabama • Phoenix, Arizona • Beverly Hills, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2007 · Synced Oct 13, 2026, 5:51 PM EDT
Terminated Phase 4 Interventional Results available

Steroids in Total Knee Arthroplasty

NCT02219581
View directory record Official record
Conditions
Postoperative Pain, Inflammation, Osteoarthritis
Interventions
Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen, Placebo
Drug
Lead sponsor
Thomas L Bradbury
Other
Eligibility
18 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Tucker, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 4, 2022 · Synced Oct 13, 2026, 5:51 PM EDT
Suspended Not applicable Interventional

Omnibond vs Dermabond

NCT05173519
View directory record Official record
Conditions
Osteoarthritis
Interventions
Omnibond Topical Skin Adhesive, Dermabond Advanced Topical Skin Adhesive
Device
Lead sponsor
Center for Innovation and Research Organization
Network
Eligibility
18 Years and older
Enrollment
310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
4
States / cities
New York, New York • New Albany, Ohio • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy Study of GRT6005 in Patients With Osteoarthritis (OA) Knee Pain

NCT01709214
View directory record Official record
Conditions
Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
Interventions
Cebranopadol (GRT6005) Low-Dose Range, Cebranopadol (GRT6005) High-Dose Range, Placebo, Oxycodone CR
Drug
Lead sponsor
Tris Pharma, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
619 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
83
States / cities
Birmingham, Alabama • Huntsville, Alabama • Phoenix, Arizona + 74 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2021 · Synced Oct 13, 2026, 5:51 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

NCT03211663
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Interventions
MOTO Medial® UKA
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
5
States / cities
Lady Lake, Florida • Louisville, Kentucky • Billings, Montana + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 13, 2026, 5:51 PM EDT
Not listed Not applicable Interventional

Post-Market Study of Robotic-Arm Assisted Total Knee Arthroplasty

NCT03106558
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Total Knee Arthroplasty using Manual Instrumentation, Total Knee Arthroplasty using Robotic Arm
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Athens, Georgia • Egg Harbor, New Jersey • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Phase 4 Interventional

Platelet Rich Plasma (PRP) in Total Knee Replacement

NCT00826098
View directory record Official record
Conditions
Osteoarthritis, Inflammatory Arthritis
Interventions
Platelet Rich Plasma
Biological
Lead sponsor
Exactech
Industry
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Lewiston, Maine • Salisbury, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 13, 2026, 5:51 PM EDT
Terminated Not applicable Interventional Results available

Uniglide™ Mobile Bearing Unicondylar Knee System vs the Uniglide™ Fixed Bearing Unicondylar Knee System

NCT00740376
View directory record Official record
Conditions
Osteoarthritis
Interventions
Uniglide Mobile Bearing Unicondylar Knee System, Uniglide Fixed Bearing Unicondylar Knee System
Device
Lead sponsor
Corin
Industry
Eligibility
40 Years to 80 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
6
States / cities
La Quinta, California • Clearwater, Florida • Lexington, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2019 · Synced Oct 13, 2026, 5:51 PM EDT
Completed Phase 2 Interventional

Vitamin D to Slow Progression of Knee Osteoarthritis

NCT00306774
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Vitamin D (cholecalciferol), Placebo
Dietary Supplement
Lead sponsor
Tufts Medical Center
Other
Eligibility
45 Years to 90 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 23, 2011 · Synced Oct 13, 2026, 5:51 PM EDT