Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results come from ClinicalTrials.gov. When the live registry is unavailable, a clearly labeled stored copy may be shown.

Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 15, 2026, 6:57 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 841–864 of 914 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Arthritis of Knee Clear all
Active, not recruiting Not applicable Interventional

Survivorship of Attune Primary Total Knee Prosthesis

NCT01754363
View directory record Official record
Conditions
Noninflammatory Degenerative Joint Disease
Interventions
Attune Primary Total Knee Replacement
Device
Lead sponsor
DePuy International
Industry
Eligibility
22 Years to 75 Years
Enrollment
1,542 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2030
U.S. locations
9
States / cities
Scottsdale, Arizona • Orange, California • DeLand, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Phase 3 Interventional

A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee

NCT05931367
View directory record Official record
Conditions
Obesity, Overweight, Osteo Arthritis Knee
Interventions
Retatrutide, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
445 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
13
States / cities
Phoenix, Arizona • San Diego, California • Waterbury, Connecticut + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 15, 2026, 6:57 AM EDT
Recruiting Not applicable Interventional

Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis

NCT06208631
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Gait retraining
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 15, 2026, 6:57 AM EDT
Completed No phase listed Observational

Osteoarthritis: Weakness From Inflammation

NCT00104312
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
50 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 29, 2009 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Not applicable Interventional

Mind-body Therapy (Remotely Delivered) for Knee Osteoarthritis

NCT04678999
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Mind-body exercise and education
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 15, 2026, 6:57 AM EDT
Withdrawn No phase listed Observational

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

NCT03893292
View directory record Official record
Conditions
Postoperative Pain, Knee Osteoarthritis
Interventions
Total knee replacement, COOLIEF
Procedure · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 15, 2026, 6:57 AM EDT
Active, not recruiting No phase listed Observational

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

NCT05197036
View directory record Official record
Conditions
Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions
Total Knee Arthroplasty
Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2033
U.S. locations
12
States / cities
Atlanta, Georgia • Boston, Massachusetts • Novi, Michigan + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Not applicable Interventional

Stem Cell and Growth Factor Injury and Arthritis Clinical Research Study

NCT03408145
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Hyaluronic Acid, Amniotic Tissue Allograft, Saline
Device · Drug
Lead sponsor
The Stone Research Foundation for Sports Medicine and Arthritis
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Oct 15, 2026, 6:57 AM EDT
Not listed No phase listed Observational

Knee Arthroplasty Registry

NCT01132365
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
any knee joint arthroplasty device
Device
Lead sponsor
Heekin Orthopedic Research Institute
Other
Eligibility
21 Years to 93 Years
Enrollment
7,793 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 26, 2016 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Phase 3 Interventional

Comparison of Hylastan to Methylprednisolone Acetate in Patients With Symptomatic Osteoarthritis of the Knee

NCT00139295
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Hylastan
Device
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
40 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
15
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2014 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Core Activation and Stabilization for Knee OA

NCT03776981
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Core Activation, Core Stabilization
Other
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
40 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Oct 15, 2026, 6:57 AM EDT
Recruiting Phase 3 Interventional

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

NCT07481630
View directory record Official record
Conditions
Obesity, Knee Osteoarthritis (OA)
Interventions
NNC0487-0111, Placebo (matched to NNC0487-0111 )
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
19
States / cities
Phoenix, Arizona • Walnut Creek, California • Hamden, Connecticut + 16 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 15, 2026, 6:57 AM EDT
Recruiting Early Phase 1 Interventional

Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis

NCT06608134
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Umbilical Cord Wharton's Jelly Allograft Intra-articular Knee Injection
Biological
Lead sponsor
R3 Medical Research
Industry
Eligibility
30 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
5
States / cities
Scottsdale, Arizona • Beverly Hills, California • Fresno, California + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2024 · Synced Oct 15, 2026, 6:57 AM EDT
Withdrawn No phase listed Observational

Post-Market Study of the EPIK Knee System

NCT01464632
View directory record Official record
Conditions
Osteoarthritis, Post Traumatic Degenerative Disease
Interventions
EPIK™ uni-compartmental knee
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Kyle, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2012 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Phase 2 Interventional

A Long-Term Safety Study of IDEA-033 in Comparison to Oral Naproxen for the Treatment of Osteoarthritis of the Knee

NCT00265304
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Ketoprofen
Drug
Lead sponsor
IDEA AG
Industry
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
93
States / cities
Birmingham, Alabama • Montgomery, Alabama • Northport, Alabama + 77 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2009 · Synced Oct 15, 2026, 6:57 AM EDT
Terminated Phase 3 Interventional Results available

Safety Extension Study Of Tanezumab When Administered By Subcutaneous Injection To Patients With Osteoarthritis

NCT01127893
View directory record Official record
Conditions
Osteoarthritis
Interventions
Tanezumab
Biological
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 99 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Phase 2 Interventional Results available

Dose Escalation Study Of Chinese Herbs In Osteoarthritis Of The Knee

NCT00755326
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
HLXL
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
40 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Phase 2 Interventional

Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

NCT06716749
View directory record Official record
Conditions
Primary Total Knee Arthroplasty, Intraosseous Morphine Injection, Knee Osteoarthritis
Interventions
Morphine, Vancomycin
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 15, 2026, 6:57 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Therapeutic Joint Arthrocentesis on Pain and Quadriceps Function in Patients With Knee Osteoarthritis

NCT04146649
View directory record Official record
Conditions
Effusion Joint
Interventions
Arthrocentesis
Procedure
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Oct 15, 2026, 6:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study of Patients Treated With the Journey Deuce Bicompartmental Knee System

NCT01704326
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
30 Years to 75 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
4
States / cities
Vero Beach, Florida • Park Ridge, Illinois • New Castle, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2012 · Synced Oct 15, 2026, 6:57 AM EDT
Completed No phase listed Observational

Adverse Events in Dry Needling

NCT03612843
View directory record Official record
Conditions
Muscle Soreness, Headache, Knee Osteoarthritis, Back Pain, Neck Pain, Needle Stick, Shoulder Pain, Hip Osteoarthritis
Interventions
Observational dry needle
Other
Lead sponsor
Elizabeth Lane
Other
Eligibility
18 Years to 100 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
8
States / cities
Acworth, Georgia • Cartersville, Georgia • Fort Oglethorpe, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 18, 2019 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Not applicable Interventional Results available

Efficacy Study of an Unloading Brace for Knee Osteoarthritis

NCT02150057
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Breg Fusion Unloading Brace
Device
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
30 Years to 80 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Oct 22, 2019 · Synced Oct 15, 2026, 6:57 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty

NCT00620828
View directory record Official record
Conditions
Osteoarthritis
Interventions
Placebo saline injection, Ropivicaine 0.5%
Other · Drug
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Oct 15, 2026, 6:57 AM EDT
Not listed No phase listed Observational

Influence of Manual Physical Therapy on Habitual Activity in Knee Osteoarthritis

NCT03573141
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Physical Therapy
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
Not listed
Enrollment
18 participants
Timeline
2018
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2018 · Synced Oct 15, 2026, 6:57 AM EDT