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ClinicalTrials.gov public records Last synced Oct 7, 2026, 6:37 PM EDT

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Showing 73–96 of 914 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Arthritis of Knee Clear all
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects

NCT04431206
View directory record Official record
Conditions
Osteoarthritis, Knee, Healthy
Interventions
Oxytocin
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Phase 3 Interventional

Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.

NCT00314652
View directory record Official record
Conditions
Osteoarthritis
Interventions
Buprenorphine transdermal delivery system
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999
U.S. locations
22
States / cities
Phoenix, Arizona • Tucson, Arizona • San Diego, California + 16 more
Source: ClinicalTrials.gov public record
Updated May 3, 2006 · Synced Oct 7, 2026, 6:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stryker Triathlon® Cruciate Substituting vs. Posterior Stabilized Outcomes Study

NCT01367925
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Stryker Triathlon® CS Tibial Insert, Stryker Triathlon® PS Tibial Insert
Device
Lead sponsor
Spokane Joint Replacement Center
Other
Eligibility
20 Years to 80 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2016
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Phase 2 Interventional

Exercise Plus Duloxetine for Knee Osteoarthritis

NCT04111627
View directory record Official record
Conditions
Knee Osteoarthritis, Depression
Interventions
Aerobic exercise, Duloxetine
Behavioral · Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
40 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Not applicable Interventional

Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain

NCT02578108
View directory record Official record
Conditions
Osteoarthritis, Knee, Pain, Nerve; Lesion
Interventions
genicular nerve diagnostic block with lidocaine (local anesthetic), genicular nerve radiofrequency ablation
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
30 Years to 80 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 21, 2019 · Synced Oct 7, 2026, 6:37 PM EDT
Terminated Phase 4 Interventional Results available

Knee Injection RCT

NCT03694821
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ketorolac Tromethamine Injection, Methylprednisolone Acetate Injection, Hylan G-F 20
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Oct 7, 2026, 6:37 PM EDT
Active, not recruiting No phase listed Observational

Post Market Follow-Up Study of the EVOLUTION® Total Knee Arthroplasty System With Cruciate Sacrificing Inserts

NCT02351414
View directory record Official record
Conditions
Joint Disease
Interventions
Total Knee Arthroplasty (EVOLUTION®)
Device
Lead sponsor
MicroPort Orthopedics Inc.
Industry
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2028
U.S. locations
1
States / cities
Morton Grove, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Not applicable Interventional

Acupuncture for Pain and Sleep Disturbance in Knee Osteoarthritis

NCT00694447
View directory record Official record
Conditions
Sleep, Pain
Interventions
Acupuncture
Procedure
Lead sponsor
Emory University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 21, 2013 · Synced Oct 7, 2026, 6:37 PM EDT
Terminated No phase listed Observational

The Knee Usual Care Evaluation Study

NCT01905358
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
30 Years to 80 Years
Enrollment
906 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2017 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Not applicable Interventional

Effect of Implanting Allogenic Cytokines Derived From Human Amniotic Membrane (HAM) and Mesenchymal Stem Cells Derived From Human Umbilical Cord Wharton's Jelly (HUMCWJ) on Pain and Functioning of Knee Osteoarthritis

NCT03337243
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Pain Chronic, Joint Disease, Arthritis, Osteo Arthritis Knee, Musculoskeletal Disease
Interventions
HAM and HUMCWJ Injections
Procedure
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
50 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2020 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Not applicable Interventional

Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis

NCT05625178
View directory record Official record
Conditions
Knee Osteoarthritis, Central Pain Syndrome
Interventions
Transcutaneous vagus nerve stimulation
Device
Lead sponsor
University of Texas, El Paso
Other
Eligibility
45 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Phase 4 Interventional

A Comparative Study of Knee Systems

NCT01331278
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Total Knee Arthroplasty with Custom Cutting Blocks, Total Knee Arthroplasty via Computer Assisted Surgery
Procedure
Lead sponsor
Foundation for Southwest Orthopedic Research
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 8, 2011 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Phase 1 Interventional

A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis

NCT03576508
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
CNTX-4975-05, Qutenza, Lidocaine (without epinephrine)
Drug
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
50 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Not applicable Interventional

Intra-articular Autologous Bone Marrow Aspirate Injection for Knee Osteoarthritis

NCT03130335
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
BMA Injection, BMA
Procedure · Biological
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 79 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Oct 7, 2026, 6:37 PM EDT
Completed No phase listed Observational

An Observational Study Evaluating the Safety, Tolerability, and Efficacy of Treatment of SM04690 or Placebo Previously Injected in the Target Knee Joint of Subjects With Moderately to Severely Symptomatic Osteoarthritis

NCT02951026
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not applicable (no therapy is administered as part of this study)
Other
Lead sponsor
Biosplice Therapeutics, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
703 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
62
States / cities
Birmingham, Alabama • Oro Valley, Arizona • Phoenix, Arizona + 59 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2020 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Not applicable Interventional Results available

An Intervention of Electrical Stimulation in Osteoarthritis

NCT00500448
View directory record Official record
Conditions
Osteoarthritis
Interventions
Electrical Stimulation
Device
Lead sponsor
University of Michigan
Other
Eligibility
50 Years to 62 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 29, 2016 · Synced Oct 7, 2026, 6:37 PM EDT
Not listed Phase 4 Interventional

Use of Cold and Compression Therapy With Total Knee Replacement Patients

NCT00712816
View directory record Official record
Conditions
Osteoarthritis, Total Knee Arthroplasty
Interventions
Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages
Device · Other
Lead sponsor
CoolSystems, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
10
States / cities
San Diego, California • Honolulu, Hawaii • Winfield, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2012 · Synced Oct 7, 2026, 6:37 PM EDT
Not listed Phase 2 Interventional

Phase II Study to Assess Safety and Efficacy of SL-1002 for Osteoarthritic Knee Pain

NCT05470608
View directory record Official record
Conditions
Osteoarthritis, Knee Pain
Interventions
SL-1002, Placebo
Drug
Lead sponsor
Saol Therapeutics Inc
Industry
Eligibility
35 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
15
States / cities
Greenwood Village, Colorado • Washington D.C., District of Columbia • Coral Gables, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Oct 7, 2026, 6:37 PM EDT
Recruiting Not applicable Interventional

Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty

NCT04814082
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Osteoarthritis, Osteoarthritis Knees Both, Osteoarthritis Knee Left, Osteoarthritis Knee Right, Knee Pain Chronic, Knee Disease, Arthropathy of Knee Joint
Interventions
MicroPort Evolution Medial-Pivot Knee System (Cruciate-substituting), Stryker Triathlon Tritanium Knee System (Condylar Stabilizing)
Device
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 22, 2025 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Phase 3 Interventional Results available

Gel-200 Versus Placebo in Osteoarthritis of the Knee

NCT00449696
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Gel-200, Placebo
Device
Lead sponsor
Seikagaku Corporation
Industry
Eligibility
40 Years to 80 Years
Enrollment
379 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Plantation, Florida
Source: ClinicalTrials.gov public record
Updated Oct 7, 2011 · Synced Oct 7, 2026, 6:37 PM EDT
Not listed Not applicable Interventional

Impact of Sensor Technology in Knee OA

NCT05222503
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Knee Brace + OPUM Digital Knee, Knee Brace
Device
Lead sponsor
OPUM Technologies US LTD
Other
Eligibility
40 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Not applicable Interventional

Stem Cell and Growth Factor Injury and Arthritis Clinical Research Study

NCT03408145
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Hyaluronic Acid, Amniotic Tissue Allograft, Saline
Device · Drug
Lead sponsor
The Stone Research Foundation for Sports Medicine and Arthritis
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Oct 7, 2026, 6:37 PM EDT
Completed Phase 3 Interventional

Study of Efficacy, Safety of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3001

NCT02336685
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Placebo, Fulranumab 1 mg, Fulranumab 3 mg, Opioid
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 99 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
36
States / cities
Birmingham, Alabama • Huntsville, Alabama • Cerritos, California + 33 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2017 · Synced Oct 7, 2026, 6:37 PM EDT
Terminated Phase 3 Interventional

A Phase 3 Study to Evaluate the Long-Term Safety of ThermoProfen™ in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee.

NCT00532038
View directory record Official record
Conditions
Osteoarthritis
Interventions
ThermoProfen™ (Matrix Transdermal Ketoprofen/CHADD™ System)
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
20
States / cities
Anaheim, California • San Diego, California • Westlake Village, California + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2012 · Synced Oct 7, 2026, 6:37 PM EDT