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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dementia Prevention Clear all
Completed Not applicable Interventional

Orexin and Tau Pathology in Cognitively Normal Elderly

NCT03053908
View directory record Official record
Conditions
Elderly, Alzheimer Disease
Interventions
Actigraphy, Nocturnal Polysomnograpahy (NPSG)
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
55 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Not applicable Interventional

Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia

NCT02675270
View directory record Official record
Conditions
Aphasia, Primary Progressive, Anomia, Alzheimer Disease
Interventions
Phonological, Orthographic, Semantic, Lexical, Untrained
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
40 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2024
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 24, 2024 · Synced Jun 10, 2026, 8:45 PM EDT
Active, not recruiting Not applicable Interventional

Reducing Racism and Discrimination in Schools: Comprehensive Prevention Services

NCT05189769
View directory record Official record
Conditions
Behavior, Child
Interventions
CP+/No REACT, CP+ and REACT
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
10 Years to 14 Years
Enrollment
1,093 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Birmingham, Alabama • Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Jun 10, 2026, 8:45 PM EDT
Enrolling by invitation Not applicable Interventional

AI-Supported Cognitive Rehabilitation for Older Adults With Mild Cognitive Impairment

NCT07474038
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
AI-Supported Cognitive Rehabilitation
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
65 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Jun 10, 2026, 8:45 PM EDT
Suspended Not applicable Interventional

Risk Screening & Primary Prevention of Elder Abuse in People Living With Dementia

NCT07429591
View directory record Official record
Conditions
Caregivers of Alzheimer's Disease or Memory Problem Patients, Caregiver Wellbeing, Elder Abuse
Interventions
Risk Assessment Screening, Coach and Website Intervention
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Ginkgo Biloba Prevention Trial in Older Individuals

NCT00010803
View directory record Official record
Conditions
Dementia, Alzheimer's Disease
Interventions
Ginkgo biloba, Placebo
Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
75 Years and older
Enrollment
3,069 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2011
U.S. locations
5
States / cities
Sacramento, California • Baltimore, Maryland • Winston-Salem, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2013 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Phase 3 Interventional Results available

Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis

NCT03325556
View directory record Official record
Conditions
Dementia-related Psychosis
Interventions
Placebo, Pimavanserin 34 mg, Pimavanserin 20 mg
Drug
Lead sponsor
ACADIA Pharmaceuticals Inc.
Industry
Eligibility
50 Years to 90 Years
Enrollment
392 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
27
States / cities
Costa Mesa, California • Fullerton, California • Aventura, Florida + 22 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2021 · Synced Jun 10, 2026, 8:45 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease

NCT02565511
View directory record Official record
Conditions
Alzheimers Disease
Interventions
CAD106 Immunotherapy, Placebo to CAD106, CNP520, Placebo to CNP520, Alum
Biological · Other · Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
60 Years to 75 Years
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
78
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Sun City, Arizona + 67 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2021 · Synced Jun 10, 2026, 8:45 PM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

The Use of Memantine for Prevention of Alzheimer's Disease

NCT05063851
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Memantine Hydrochloride Tablets, Placebo
Drug
Lead sponsor
University of Virginia
Other
Eligibility
50 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Retain Your Brain Health Study (RetainYourBrain.com)

NCT06027320
View directory record Official record
Conditions
Alzheimer Disease, Dementia, Healthy Participants, Brain Health
Interventions
Brain Health Education, Alzheimer Disease Education
Behavioral
Lead sponsor
Retain Health, Inc
Other
Eligibility
53 Years to 105 Years
Enrollment
992 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 31, 2024 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Not applicable Interventional

The PREVENTION Trial: Precision Recommendations to Optimize Neurocognition

NCT04082611
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment
Interventions
Data-Driven Clinical Recommendations, Coached Data-Driven Clinical Recommendations
Behavioral
Lead sponsor
Saint John's Cancer Institute
Other
Eligibility
50 Years to 80 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Jun 10, 2026, 8:45 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)

NCT07180147
View directory record Official record
Conditions
Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome, Disability Physical, Hypertension, Metabolic Syndrome (MetS), Healthy Aging, Obesity &Amp; Overweight
Interventions
Not listed
Lead sponsor
Marymount University
Other
Eligibility
50 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2031
U.S. locations
1
States / cities
Arlington, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Jun 10, 2026, 8:45 PM EDT
Enrolling by invitation Not applicable Interventional

The Nightlight Falls Prevention Study

NCT05973448
View directory record Official record
Conditions
Aging, Alzheimer Disease, Dementia Alzheimers, Dementia of Alzheimer Type, Fall Injury
Interventions
Novel Lighting Condition, Control Lighting Condition
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
335 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

aeRobic Exercise and Cognitive Health

NCT02384993
View directory record Official record
Conditions
Alzheimer's Disease, Aging
Interventions
Enhanced Physical Activity
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
45 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 17, 2024 · Synced Jun 10, 2026, 8:45 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Alzheimer Prevention Trials (APT) Webstudy

NCT03638583
View directory record Official record
Conditions
Alzheimer Disease, Dementia
Interventions
Not listed
Lead sponsor
University of Southern California
Other
Eligibility
50 Years to 85 Years
Enrollment
200,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Jun 10, 2026, 8:45 PM EDT
Recruiting No phase listed Observational

Trial-Ready Cohort-Down Syndrome (TRC-DS)

NCT04165109
View directory record Official record
Conditions
Down Syndrome, Alzheimer Disease, Dementia
Interventions
Not listed
Lead sponsor
University of Southern California
Other
Eligibility
25 Years to 55 Years
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
18
States / cities
Phoenix, Arizona • Orange, California • Aurora, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study

NCT01729598
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Valproic Acid, Placebo
Drug
Lead sponsor
Gregory Jicha, 323-5550
Other
Eligibility
65 Years to 90 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Jun 10, 2026, 8:45 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Fall Detection and Prevention for Memory Care Through Real-time Artificial Intelligence Applied to Video

NCT03685240
View directory record Official record
Conditions
Alzheimer's Disease and Related Dementia, Fall Injury
Interventions
SafelyYou Fall Prevention System
Behavioral
Lead sponsor
SafelyYou
Industry
Eligibility
18 Years and older
Enrollment
460 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Jun 10, 2026, 8:45 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Aspirin in Reducing Events in the Elderly

NCT01038583
View directory record Official record
Conditions
Functional Disability, Dementia, Heart Disease, Stroke, Cancer, Bleeding, Depression
Interventions
100 mg enteric-coated aspirin, Placebo
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
65 Years and older
Enrollment
19,114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2024
U.S. locations
33
States / cities
Birmingham, Alabama • Palo Alto, California • Washington D.C., District of Columbia + 26 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2021 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prevention of Depression in Spouses of People With Cognitive Impairment

NCT00321971
View directory record Official record
Conditions
Depression
Interventions
PST-MCI/AD Caregiving, NT-MCI/AD Caregiving
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Not applicable Interventional

The Mental Activity and eXercise Trial for Seniors

NCT00522899
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Group 1, Group 2, Group 3, Group 4
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
65 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2012 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Phase 2 Interventional Results available

Ramelteon in the Prevention of Post-operative Delirium

NCT02324153
View directory record Official record
Conditions
Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders, Delayed Emergence From Anesthesia, Cognitive Disorders
Interventions
Ramelteon, Microcrystalline Cellulose, Riboflavin 100 mg
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults

NCT04723602
View directory record Official record
Conditions
Ebola Virus Disease, Marburg Virus Disease
Interventions
cAd3-Marburg, cAd3-EBO-S
Biological
Lead sponsor
Albert B. Sabin Vaccine Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Jun 10, 2026, 8:45 PM EDT
Completed Phase 4 Interventional

Donepezil in the Prevention of Post-Operative Cognitive Decline

NCT00182845
View directory record Official record
Conditions
Postoperative Complications, Delirium
Interventions
Donepezil
Drug
Lead sponsor
Pfizer
Industry
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 2, 2008 · Synced Jun 10, 2026, 8:45 PM EDT