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Showing 1–24 of 5,219 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Depressive Illness Clear all
Recruiting Not applicable Interventional

ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics

NCT07360600
View directory record Official record
Conditions
Parents, Children With Disabilities, Stress, Depression
Interventions
ACT Together
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Phase 4 Interventional Results available

Antidepressant Treatment at an Inner City Asthma Clinic

NCT01324700
View directory record Official record
Conditions
Depression, Asthma
Interventions
High severity group: Escitalopram, High severity group: Placebo, Low severity group: Escitalopram, Low severity group: Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Not applicable Interventional Results available

Brief Video Interventions for Depression

NCT04643964
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Entrée: Cognitive skills, Entrée: Behavioral skills, Entrée: Interpersonal skills, Sampler skills
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
655 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 19, 2024 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Guided Self-help for Common Mental Disorders

NCT04870099
View directory record Official record
Conditions
Bibliotherapy
Interventions
Doing What Matters in Times of Stress: An Illustrated Guide
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Jul 23, 2026, 1:30 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Intern Health Study 2025

NCT07052357
View directory record Official record
Conditions
Depression - Major Depressive Disorder, Mood, Sleep, Physical Activity
Interventions
Intern Health Study behavioral change mobile notification
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

FACE-PC: Family-Centered Care for Older Adults With Depression and Chronic Medical Conditions in Primary Care

NCT03094871
View directory record Official record
Conditions
Chronic Medical Conditions, Depression
Interventions
FACE-PC
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 14, 2021 · Synced Jul 23, 2026, 1:30 PM EDT
Withdrawn Phase 3 Interventional

A Study to Decrease Suicidal Thinking Using Ketamine

NCT02418702
View directory record Official record
Conditions
Depression, Suicide
Interventions
0.2 mg/kg ketamine, placebo
Drug · Other
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 2, 2019 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mind-Body Skills Groups for the Treatment of War Zone Stress in Military and Veteran Populations

NCT01093053
View directory record Official record
Conditions
Stress Disorders, Post Traumatic, Brain Injuries, Depressive Disorder, Anxiety Disorders, Anger
Interventions
Mind-Body Skills Groups, Standard Treatment
Behavioral · Other
Lead sponsor
The Center for Mind-Body Medicine
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 28, 2014 · Synced Jul 23, 2026, 1:30 PM EDT
Recruiting Not applicable Interventional

SUpport From PEeRs to Expand Access Study - Community

NCT07186816
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Behavioral: Supported dCBT, Behavioral: Unsupported dCBT
Device
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 100 Years
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Jul 23, 2026, 1:30 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

The Effects of Trauma-sensitive Yoga and Tai Chi on Mental Health

NCT04754009
View directory record Official record
Conditions
Mental Health Wellness 1
Interventions
Trauma-Sensitive Yoga + TAU, Chen Style Tai Chi + TAU, Treatment as Usual
Behavioral
Lead sponsor
University of Northern Iowa
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cedar Falls, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of a Single-session Implicit Theories of Personality Intervention on Early Adolescent Psychopathology

NCT03132298
View directory record Official record
Conditions
Anxiety Symptoms, Depressive Symptoms
Interventions
Implicit Theories of Personality Program, Control Program
Other
Lead sponsor
Harvard University
Other
Eligibility
12 Years to 15 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 6, 2019 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Not applicable Interventional Results available

Depression, Obesity and Inflammatory Markers

NCT02765100
View directory record Official record
Conditions
Bipolar Disorder, Depression, Obesity
Interventions
Minocycline
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 99 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Jul 23, 2026, 1:30 PM EDT
Recruiting Not applicable Interventional

BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Urinary Incontinence in Postpartum and Early Post-Childbirth Women

NCT07413692
View directory record Official record
Conditions
Depressive Symptoms, Urinary Incontinence
Interventions
EXOMIND (BTL-699-2) ActiveTreatment, EMSELLA (HPM-6000UF) ActiveTreatment, EXOMIND (BTL-699-2) Sham Treatment, EMSELLA (HPM-6000UF) Sham Treatment
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years to 60 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Garfield Heights, Ohio • Oklahoma City, Oklahoma • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 23, 2026, 1:30 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Exploring Biomarkers for Depression

NCT01424111
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Escitalopram, Healthy Control
Drug · Other
Lead sponsor
Wyss Institute at Harvard University
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Phase 4 Interventional Results available

Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses

NCT00305565
View directory record Official record
Conditions
Depression
Interventions
VNS Therapy
Device
Lead sponsor
Cyberonics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
26
States / cities
Tucson, Arizona • Sacramento, California • Marietta, Georgia + 21 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2014 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Phase 2 Interventional Results available

Ketamine and Nitroprusside for Depression

NCT03102736
View directory record Official record
Conditions
Depression
Interventions
Placebos, Ketamine, Nitroprusside
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2020 · Synced Jul 23, 2026, 1:30 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment

NCT03519451
View directory record Official record
Conditions
Depression, Tobacco Use Disorder, Current Every Day Smoker
Interventions
Internet-Based Intervention, Questionnaire Administration
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Internet and Telephone Support Intervention for Stroke Caregivers

NCT04348851
View directory record Official record
Conditions
Depression, Quality of Life, Recovery of Function, Self Efficacy, Stress
Interventions
Caregiver problem-solving, Attention Control
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 1, 2020 · Synced Jul 23, 2026, 1:30 PM EDT
Completed No phase listed Observational

Mild Depression 2 Week Observational Study

NCT00285831
View directory record Official record
Conditions
Depressive Disorder
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2019 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Phase 1Phase 2 Interventional

ALK33BUP-201: Safety and Tolerability Study of ALKS 33-BUP (ALKS 5461) Administration in Subjects With MDD

NCT01381107
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
ALKS 5461, Placebo
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
2
States / cities
St. Petersburg, Florida • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 22, 2011 · Synced Jul 23, 2026, 1:30 PM EDT
Recruiting Not applicable Interventional

A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression

NCT07112001
View directory record Official record
Conditions
HIV, Depression, Anxiety
Interventions
PositiveLinks with Counseling, Standard of Care (SOC)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Jul 23, 2026, 1:30 PM EDT
Recruiting Not applicable Interventional

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

NCT06423430
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Sham-stimulation, Active-stimulation
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
22 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
24
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Not applicable Interventional

TODAY! A Mobile App Study

NCT03534167
View directory record Official record
Conditions
Depression, Anxiety
Interventions
TODAY! App and Coaching
Behavioral
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
14 Years to 24 Years · Male only
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 2, 2023 · Synced Jul 23, 2026, 1:30 PM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate ALKS 5461 in Subjects With Major Depressive Disorder (MDD)

NCT01500200
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
ALKS 5461, Placebo
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
27
States / cities
Tucson, Arizona • Oceanside, California • Santa Ana, California + 24 more
Source: ClinicalTrials.gov public record
Updated May 20, 2019 · Synced Jul 23, 2026, 1:30 PM EDT