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ClinicalTrials.gov public records Last synced Oct 21, 2026, 1:14 PM EDT

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Showing 1–24 of 61 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Diskectomy Clear all
Terminated No phase listed Observational

PureGen: Radiographic Analysis of Fusion for ACDF

NCT01291134
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
PureGen Osteoprogenitor Cell Allograft
Biological
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Carlsbad, California • Middletown, Connecticut • Greensboro, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Oct 21, 2026, 1:14 PM EDT
Completed Not applicable Interventional Results available

LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE

NCT00389597
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Cervical Artificial Disc
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
18 Years to 69 Years
Enrollment
599 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
24
States / cities
Phoenix, Arizona • Escondido, California • Laguna Hills, California + 21 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Oct 21, 2026, 1:14 PM EDT
Completed Not applicable Interventional

Safety Study of Preservon-Treated Bone Implants for Cervical Fusion in the Treatment of Cervical Radiculopathy or Myelopathy

NCT00344890
View directory record Official record
Conditions
Cervical Radiculopathy, Myelopathy
Interventions
Anterior Cervical Discectomy and Fusion
Procedure
Lead sponsor
LifeNet Health
Industry
Eligibility
18 Years to 65 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 21, 2026, 1:14 PM EDT
Completed No phase listed Observational

Trinity Evolution in Anterior Cervical Disectomy and Fusion (ACDF)

NCT00951938
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
13
States / cities
Encinitas, California • Redding, California • Parker, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2014 · Synced Oct 21, 2026, 1:14 PM EDT
Completed Phase 3 Interventional Results available

Performance of the Hedrocel(R) Cervical Fusion Device

NCT00758758
View directory record Official record
Conditions
Symptomatic Cervical Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 70 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
13
States / cities
Los Angeles, California • Clearwater, Florida • Orlando, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2013 · Synced Oct 21, 2026, 1:14 PM EDT
Active, not recruiting Not applicable Interventional

The Synergy Disc To Anterior Cervical Discectomy and Fusion

NCT04469231
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy & Fusion
Device
Lead sponsor
Synergy Spine Solutions
Industry
Eligibility
18 Years to 70 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
20
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Beverly Hills, California + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 21, 2026, 1:14 PM EDT
Completed Not applicable Interventional Results available

Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)

NCT02182843
View directory record Official record
Conditions
Cervical Disc Degenerative Disorder
Interventions
Cellentra VCBM
Biological
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
6
States / cities
Phoenix, Arizona • Fort Wayne, Indiana • Paducah, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2019 · Synced Oct 21, 2026, 1:14 PM EDT
Not listed No phase listed Observational

Lumbar Discectomy Control Study, Risk Factors for Reherniation

NCT02477176
View directory record Official record
Conditions
Lumbar Spine Disc Herniation
Interventions
Discectomy
Other
Lead sponsor
Intrinsic Therapeutics
Industry
Eligibility
21 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
4
States / cities
Chicago, Illinois • Galena, Kansas • Paducah, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 21, 2026, 1:14 PM EDT
Completed Phase 4 Interventional

Randomized Study of Anular Repair With the Xclose Tissue Repair System

NCT00760799
View directory record Official record
Conditions
Diskectomy
Interventions
Discectomy with anular repair
Procedure
Lead sponsor
Anulex Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
34
States / cities
Huntsville, Alabama • Phoenix, Arizona • San Diego, California + 25 more
Source: ClinicalTrials.gov public record
Updated May 2, 2012 · Synced Oct 21, 2026, 1:14 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

The Effect of IV NSAID's and Corticosteroids on Dysphasia and Dysphonia Following ASDF

NCT04650893
View directory record Official record
Conditions
Dysphagia, Dysphonia
Interventions
Intravenous Ketorolac, Intravenous Dexamethasone, Placebo
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 23, 2024 · Synced Oct 21, 2026, 1:14 PM EDT
Not listed Not applicable Interventional

Short Versus Long Post-Operative Restrictions Following Lumbar Discectomy

NCT01363830
View directory record Official record
Conditions
Lumbar Disc Herniation
Interventions
Two-Week Post-Operative Restriction, Six-Week Post-Operative Restriction
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2013 · Synced Oct 21, 2026, 1:14 PM EDT
Recruiting Not applicable Interventional

Function After Anterior Cervical Discectomy and Fusion Surgery: Timing of Physical Therapy

NCT06202443
View directory record Official record
Conditions
Cervical Spine Degeneration, ACDF Surgery
Interventions
Early PT, Delayed PT
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Honolulu, Hawaii • Nashville, Tennessee • Fort Sam Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 21, 2026, 1:14 PM EDT
Not listed Phase 3 Interventional

Randomized Trial of Intraoperative IV Versus Preoperative Oral Acetaminophen During Ambulatory Lumbar Discectomy

NCT04574778
View directory record Official record
Conditions
Pain, Postoperative, Spine Surgery
Interventions
Acetaminophen
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 12, 2024 · Synced Oct 21, 2026, 1:14 PM EDT
Terminated Phase 4 Interventional Results available

Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery

NCT04990804
View directory record Official record
Conditions
Opioid Use, Spinal Diseases, Surgery--Complications, Surgery, Postoperative Pain
Interventions
Opioid Analgesic, Opioid-Free Postoperative Pain Regimen
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Oct 21, 2026, 1:14 PM EDT
Withdrawn Not applicable Interventional

Stand-Alone Cage Verus Anterior Plating for Anterior Cervical Discectomy and Fusion.

NCT03312192
View directory record Official record
Conditions
Degenerative Disc Disease, Cervical Spine Degeneration
Interventions
Interbody Cage, Interbody Cage and Anterior Plating
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 21, 2026, 1:14 PM EDT
Completed Phase 4 Interventional Results available

Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery

NCT03643796
View directory record Official record
Conditions
Anterior Cervical Discectomy and Fusion (ACDF)
Interventions
Remifentanil, Ketamine, Dexmedetomidine
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2023 · Synced Oct 21, 2026, 1:14 PM EDT
Enrolling by invitation Not applicable Interventional

Effectiveness of AlloWrap® for the Reduction of Inflammation in ACDF Procedures

NCT04684901
View directory record Official record
Conditions
Cervical Stenosis, Spondylolisthesis, Cervical Radiculopathy, Cervical Disc Disorder
Interventions
AlloWrap® Amniotic Membrane
Other
Lead sponsor
AlloSource
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 21, 2026, 1:14 PM EDT
Active, not recruiting Not applicable Interventional

The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery

NCT05740176
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion
Device
Lead sponsor
Synergy Spine Solutions
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
23
States / cities
Scottsdale, Arizona • Beverly Hills, California • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 21, 2026, 1:14 PM EDT
Completed Not applicable Interventional Results available

An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation

NCT00310440
View directory record Official record
Conditions
Intervertebral Disk Degeneration
Interventions
P-15 Synthetic osteoconductive bone substitute, Autologous bone
Device · Other
Lead sponsor
CeraPedics, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2019
U.S. locations
10
States / cities
San Francisco, California • Thornton, Colorado • Sarasota, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Oct 21, 2026, 1:14 PM EDT
Recruiting Not applicable Interventional

Opioid Dispenser for Microdiscectomy/Laminectomy

NCT06358040
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative, Medical Device, Laminectomy, Diskectomy
Interventions
Opioid-Dispensing Device, App, Standard Opioid Pill Bottle
Device · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Oct 21, 2026, 1:14 PM EDT
Terminated Not applicable Interventional Results available

Advent™ Cervical Disc Versus ACDF for Treatment of One Level Degenerative Disc Disease (IDE Study)

NCT00637312
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Cervical Artificial Disc (Advent™ Cervical Disc), Hallmark™ Anterior Cervical Plate System
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
13
States / cities
Sacramento, California • Boulder, Colorado • Tampa, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2014 · Synced Oct 21, 2026, 1:14 PM EDT
Withdrawn No phase listed Observational

Incidence of Large Annular Defects in Primary Lumbar Discectomy Patients

NCT03252691
View directory record Official record
Conditions
Lumbar Disc Herniation, Anular Tear of Lumbar Disc, Nucleus Pulp Hernia;Lumbosac
Interventions
Not listed
Lead sponsor
Intrinsic Therapeutics
Industry
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Oct 21, 2026, 1:14 PM EDT
Terminated Not applicable Interventional Results available

Prospective Study of Fusion Rates Using Spira-C Device for Anterior Cervical Discectomy and Fusion Surgery

NCT03786432
View directory record Official record
Conditions
Cervical Radiculopathy, Cervical Disc Disease
Interventions
Spira-C Interbody Device
Device
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 21, 2026, 1:14 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Prophylactic Racemic Epinephrine in Anterior Cervical Discectomy and Fusion

NCT02724761
View directory record Official record
Conditions
Dysphagia, Dysphonia, Postoperative Pain
Interventions
Racemic Epinephrine, Placebo (for racemic epinephrine)
Drug
Lead sponsor
Andrew Chung
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 31, 2016 · Synced Oct 21, 2026, 1:14 PM EDT