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Conditions: Down Syndrome, Augmentative and Alternative Communication
Interventions: AAC Technology - Standard of Care, AAC Technology - non-optimal integrated arrangement; Device
Lead sponsor: Penn State University; Other
Eligibility: 7 Years to 35 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Down Syndrome, Cognitive Dysfunction
Interventions: Aricept (Donepezil hydrochloride), Placebo; Drug
Lead sponsor: Eisai Inc.; Industry
Eligibility: 6 Years to 10 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 2
States / cities: San Antonio, Texas • Herndon, Virginia

Conditions: Congenital Disorders
Interventions: Not listed
Lead sponsor: Children's Healthcare of Atlanta; Other
Eligibility: Up to 8 Days
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Down Syndrome
Interventions: Down Syndrome Clinic to You (DSC2U); Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 1 Year and older
Enrollment: 281 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Down Syndrome, Fetal Aneuploidy
Interventions: Not listed
Lead sponsor: Sequenom, Inc.; Industry
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 3,062 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 27
States / cities: Mobile, Alabama • Tucson, Arizona • Campbell, California + 24 more

Conditions: Intellectual Disability, Overweight and Obesity
Interventions: Weight Loss Plus Cooking, Traditional Weight Loss; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years to 35 Years
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Down Syndrome, Adaptive Behavior, Quality of Life
Interventions: The MapHabit System; Device
Lead sponsor: MapHabit, Inc.; Industry
Eligibility: 7 Years to 17 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome, Fragile X Syndrome, Cri-du-Chat Syndrome, De Lange Syndrome, Mental Retardation, X-Linked, Prader-Willi Syndrome, Rubinstein-Taybi Syndrome, Trisomy 13 Syndrome, WAGR Syndrome, Williams Syndrome
Interventions: PACE Program; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 376 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Fayetteville, Arkansas • Chapel Hill, North Carolina

Conditions: Down Syndrome
Interventions: Rivastigmine, Liquid Placebo; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 10 Years to 17 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: Baltimore, Maryland • Durham, North Carolina

Conditions: Anxiety Disorders, Child Developmental Disorders, Pervasive
Interventions: Not listed
Lead sponsor: University of California, Davis; Other
Eligibility: 5 Years to 25 Years
Enrollment: 511 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Pregnant Women, Prenatal Care
Interventions: Not listed
Lead sponsor: Verinata Health, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 10,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 11
States / cities: Los Angeles, California • San Francisco, California • Fort Collins, Colorado + 8 more

Conditions: Obstructive Sleep Apnea of Child
Interventions: Adenotonsillectomy, Drug-induced sleep endoscopy directed surgery; Procedure
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 2 Years to 18 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Down Syndrome (Trisomy 21)
Interventions: Not listed
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 18 Years to 35 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Refractive Error Correction, Visual Acuity
Interventions: Metric-optimized spectacles, Routine Clinical Spectacles; Device
Lead sponsor: Ohio State University; Other
Eligibility: 5 Years to 12 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Caregiver Burden
Interventions: Physical Activity Program, Waitlist for Physical Activity Program; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 25 Years to 50 Years · Female only
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis, Asthma, Atopic Dermatitis Eczema, Beta Thalassemia, Bipolar Disorder, Breast Cancer, Celiac Disease, Cervical Cancer, Chronic Inflammatory Demyelinating Polyneuropathy, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease, Colon Cancer, Colorectal Cancer, Crohn's Disease, Cystic Fibrosis, Depression, Diabetes Mellitus, Duchenne Muscular Dystrophy, Endometriosis, Epilepsy, Facioscapulohumeral Muscular Dystrophy, G6PD Deficiency, General Anxiety Disorder, Hepatitis B, Hereditary Hemorrhagic Telangiectasia, HIV/AIDS, Human Papilloma Virus, Huntington's Disease, Idiopathic Thrombocytopenic Purpura, Insomnia, Kidney Cancer, Leukemia, Lung Cancer, Lupus Nephritis, Lymphoma, Melanoma, Multiple Myeloma, Multiple Sclerosis, Myositis, Myotonic Dystrophy, Ovarian Cancer, Pancreatic Cancer, Parkinson's Disease, Polycystic Kidney Diseases, Prostate Cancer, Psoriasis, Psoriatic Arthritis, Rosacea, Scleroderma, Sickle Cell Anemia, Sickle Cell Trait, Sjogren's Syndrome, Skin Cancer, Spinal Muscular Atrophy, Systemic Lupus Erythematosus, Thrombotic Thrombocytopenic Purpura, Trisomy 21, Ulcerative Colitis
Interventions: Not listed
Lead sponsor: Sanguine Biosciences; Industry
Eligibility: 18 Years to 100 Years
Enrollment: 17,667 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Down Syndrome, Recurrent B Acute Lymphoblastic Leukemia
Interventions: 3-Dimensional Conformal Radiation Therapy, Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration, Bone Marrow Biopsy, Calaspargase Pegol, Cytarabine, Dexamethasone, Hydrocortisone Sodium Succinate, Lumbar Puncture, Mercaptopurine, Methotrexate, Nivolumab, Pegaspargase, Vincristine Sulfate; Radiation · Drug · Procedure + 1 more
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 1 Year to 30 Years
Enrollment: 461 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 209
States / cities: Birmingham, Alabama • Mobile, Alabama • Anchorage, Alaska + 150 more

Conditions: Speech Intelligibility Intervention in Down Syndrome
Interventions: Lexically based speech recast; Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 4 Years to 17 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Down Syndrome
Interventions: Treadmill Training, Supramalleolar Orthoses; Behavioral · Device
Lead sponsor: University of Michigan; Other
Eligibility: 6 Months to 36 Months
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Dysarthria, Down Syndrome
Interventions: Speech sessions; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 8 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Down Syndrome
Interventions: Babble Boot Camp; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 0 Months to 12 Months
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Tempe, Arizona

Conditions: Down Syndrome, Depression
Interventions: Fluoxetine; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Lexington, Massachusetts

Conditions: Obstructive Sleep Apnea (OSA), Down Syndrome
Interventions: ato-oxy, Oxygen; Drug
Lead sponsor: University of Arizona; Other
Eligibility: 6 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 5
States / cities: Tucson, Arizona • San Diego, California • Miami, Florida + 2 more

Conditions: Neurodevelopmental Disorders, Autism Spectrum Disorder, Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection, Pediatric Acute-Onset Neuropsychiatric Syndrome, Down Syndrome, Epilepsy, Mitochondrial Encephalomyopathies, Cerebral Folate Deficiency
Interventions: Not listed
Lead sponsor: Richard Frye; Other
Eligibility: Not listed
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: Phoenix, Arizona

Search by objective public record fields.

Storybook Reading in Individuals With Down Syndrome

Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10

Pulmonary Hypertension in Trisomy 21 Patients

An Online Health Tool About Down Syndrome: Down Syndrome Clinic to You

Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies

Cooking Skills to Improve Long-Term Weight Loss in Young Adults With Intellectual Disabilities

Life Skills Improved in Children With Down Syndrome After Using Assistive Technology

Physical Activity and Community EmPOWERment Project

Rivastigmine Study in Adolescents With Down Syndrome

Examining Social, Emotional, and Cognitive Functioning in People With Fragile X and Down Syndromes

MatErnal BLood IS Source to Accurately Diagnose Fetal Aneuploidy

Surgical Treatment of Children With OSA and Small Tonsils or Down Syndrome

Vascular Function in Adults With Down Syndrome

Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome

10-Week Physical Activity Program for Mothers of Children With Developmental Disabilities

At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Predictors of Speech Ability in Down Syndrome

Treadmill Training and Orthotic Use in Infants With Down Syndrome

Intensive Dysarthria Sessions in Adults and Children With Down Syndrome

Proactive Speech and Language Intervention for Infants With Down Syndrome

Fluoxetine Treatment of Depression in Down Syndrome

Endotype DIrected Treatment for OSA in Down Syndrome

Patterns of Neurodevelopmental Disorders