Search | Clinical Trials Finder

Conditions: Pregnancy
Interventions: Control - computerized age-appropriate prenatal testing educational brochure, PT Tool - interactive, computerized, prenatal testing decision tool; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 16 Years to 50 Years · Female only
Enrollment: 494 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2004
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Down Syndrome
Interventions: Donepezil HCl, Placebo; Drug
Lead sponsor: Eisai Inc.; Industry
Eligibility: 10 Years to 17 Years
Enrollment: 129 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 31
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 25 more

Conditions: Obstructive Sleep Apnea, Down Syndrome
Interventions: Sleep study; Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 2 Years to 17 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Developmental Disability, Autism Spectrum Disorder, Down Syndrome, Cerebral Palsy
Interventions: Zumba High Tempo, Zumba Low Tempo; Behavioral
Lead sponsor: Auburn University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Auburn, Alabama

Conditions: Dysarthria, Down Syndrome
Interventions: Speech sessions; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 8 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Developmental Disabilities, Weight Loss, Body Weight, Down Syndrome, Body Weight Changes, Intellectual Disability
Interventions: Enhanced Stop Light Diet (eSLD), Conventional Diet (CD), Face-to-face (FTF), Technology (TECH), iPad with FaceTime; Dietary Supplement · Behavioral · Other
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 13 Years to 21 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 2
States / cities: Kansas City, Kansas • Lawrence, Kansas

Conditions: Down Syndrome
Interventions: Not listed
Lead sponsor: University of Colorado, Denver; Other
Eligibility: Not listed
Enrollment: 100,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2035
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Autism Spectrum Disorder, Down Syndrome
Interventions: Bicycle Training Intervention; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 9 Years to 18 Years
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 3
States / cities: Southbend, Indiana • Ann Arbor, Michigan • Grand Rapids, Michigan

Conditions: Language Impairment, Down Syndrome
Interventions: Jasper-EMT with words and AAC; Behavioral
Lead sponsor: Vanderbilt University; Other
Eligibility: 30 Months to 54 Months
Enrollment: 78 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 2
States / cities: Los Angeles, California • Nashville, Tennessee

Conditions: Down Syndrome, Intellectual Disability
Interventions: Memantine, Placebo; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 15 Years to 32 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Turner Syndrome
Interventions: Not listed
Lead sponsor: Sequenom, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 7
States / cities: La Jolla, California • San Diego, California • San Jose, California + 4 more

Conditions: Down Syndrome, Alzheimer's Disease
Interventions: Not listed
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 45 Years and older
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Alzheimer's Disease in Down Syndrome
Interventions: Not listed
Lead sponsor: LuMind IDSC Foundation; Other
Eligibility: 25 Years and older
Enrollment: 252 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 14
States / cities: Phoenix, Arizona • Irvine, California • La Jolla, California + 11 more

Conditions: Down Syndrome, Intellectual Disability
Interventions: Memantine; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 15 Years to 32 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Congenital Disorders
Interventions: Not listed
Lead sponsor: Children's Healthcare of Atlanta; Other
Eligibility: Up to 8 Days
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
Interventions: Epi-ON corneal cross-linking (CXL); Combination Product
Lead sponsor: Woolfson Eye Institute; Other
Eligibility: 8 Years and older
Enrollment: 225 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 12
States / cities: Atlanta, Georgia • Canton, Georgia • Cumming, Georgia + 8 more

Conditions: Down Syndrome, Intellectual Disability, Sexuality, Parent-Child Relations
Interventions: Parent training; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: Not listed
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Park Ridge, Illinois

Conditions: Down Syndrome
Interventions: Not listed
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 6 Years to 35 Years
Enrollment: 202 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2026
U.S. locations: 2
States / cities: Fort Collins, Colorado • Cincinnati, Ohio

Conditions: Mental Retardation, Developmental Disabilities, Intellectual Disabilities
Interventions: Healthy Lifestyles Curriculum; Behavioral
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 131 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Down Syndrome, Subclinical Hypothyroidism
Interventions: Levothyroxine; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 8 Years to 20 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Philadelphia, Pennsylvania

Conditions: Down Syndrome
Interventions: Treadmill Training, Supramalleolar Orthoses; Behavioral · Device
Lead sponsor: University of Michigan; Other
Eligibility: 6 Months to 36 Months
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
Interventions: asparaginase, cytarabine, daunorubicin hydrochloride, methotrexate, therapeutic hydrocortisone, thioguanine; Drug
Lead sponsor: Children's Oncology Group; Network
Eligibility: Up to 21 Years
Enrollment: 254 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2012
U.S. locations: 209
States / cities: Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 151 more

Conditions: Down Syndrome, Edwards Syndrome, Patau Syndrome, Turner Syndrome
Interventions: Not listed
Lead sponsor: Sequenom, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Childhood Acute Basophilic Leukemia, Childhood Acute Eosinophilic Leukemia, Childhood Acute Erythroleukemia (M6), Childhood Acute Megakaryocytic Leukemia (M7), Childhood Acute Minimally Differentiated Myeloid Leukemia (M0), Childhood Acute Monoblastic Leukemia (M5a), Childhood Acute Monocytic Leukemia (M5b), Childhood Acute Myeloblastic Leukemia With Maturation (M2), Childhood Acute Myeloblastic Leukemia Without Maturation (M1), Childhood Acute Myelomonocytic Leukemia (M4), Childhood Myelodysplastic Syndromes, de Novo Myelodysplastic Syndromes, Secondary Acute Myeloid Leukemia, Secondary Myelodysplastic Syndromes, Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions: asparaginase, daunorubicin hydrochloride, cytarabine, thioguanine, etoposide, laboratory biomarker analysis; Drug · Other
Lead sponsor: Children's Oncology Group; Network
Eligibility: Up to 4 Years
Enrollment: 205 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2021
U.S. locations: 88
States / cities: Phoenix, Arizona • Downey, California • Long Beach, California + 73 more

Search by objective public record fields.

Evaluation of a Decision Assisting Tool for Prenatal Testing

Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome

Validation of Sleep Questionnaires in the Down Syndrome Population

The Effects of Virtual Zumba® in Individuals With Developmental Disabilities

Intensive Dysarthria Sessions in Adults and Children With Down Syndrome

Weight Management for Adolescents With IDD

DS-Connect®: The Down Syndrome Registry

A Bicycle Training Intervention

Phenotypic Specific Communication Intervention for Children With Down Syndrome

Down Syndrome Memantine Follow-up Study

Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker

Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia

Down Syndrome Clinical Trials - Study of Alzheimer's Disease in Down Syndrome

Escalating Doses of Memantine in Down Syndrome (MEDS-123)

Pulmonary Hypertension in Trisomy 21 Patients

Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome

Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome

Evaluating Cognitive Outcomes in Down Syndrome

Healthy Lifestyles for People With Intellectual Disabilities

Treatment Trial of Subclinical Hypothyroidism in Down Syndrome

Treadmill Training and Orthotic Use in Infants With Down Syndrome

Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome

Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies

Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes