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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Essential Tremor-plus Clear all
Completed Phase 2 Interventional Results available

A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor

NCT04305275
View directory record Official record
Conditions
Essential Tremor
Interventions
SAGE-324, SAGE-324 Placebo
Drug
Lead sponsor
Sage Therapeutics
Industry
Eligibility
18 Years to 80 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
27
States / cities
Phoenix, Arizona • Rogers, Arkansas • Fresno, California + 23 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Sep 21, 2026, 7:41 PM EDT
Completed No phase listed Observational

Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.

NCT02132052
View directory record Official record
Conditions
Essential Tremor, Multiple System Atrophy, Corticobasal Degeneration, Supranuclear Palsy, Progressive, Parkinson Disease
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 24, 2021 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 2 Interventional Results available

A Clinical Trial of PRAX-944 in Participants With Essential Tremor

NCT05021978
View directory record Official record
Conditions
Essential Tremor
Interventions
Part A: 20 and 40 mg PRAX-944, Part B: 120 mg PRAX-944, Part B: 120 mg PRAX-944 and Placebo
Drug
Lead sponsor
Praxis Precision Medicines
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Port Charlotte, Florida • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Feb 29, 2024 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate SAGE-217 in Participants With Essential Tremor

NCT02978781
View directory record Official record
Conditions
Essential Tremor
Interventions
SAGE-217, Placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 80 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
26
States / cities
Anniston, Alabama • Little Rock, Arkansas • Rogers, Arkansas + 23 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Not applicable Interventional

RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor

NCT05540626
View directory record Official record
Conditions
Essential Tremor
Interventions
Cala Trio
Device
Lead sponsor
Cala Health, Inc.
Industry
Eligibility
22 Years and older
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
San Mateo, California
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Not applicable Interventional

Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands

NCT05480215
View directory record Official record
Conditions
Essential Tremor, Parkinson Disease
Interventions
Cala Device
Device
Lead sponsor
Cala Health, Inc.
Industry
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
San Mateo, California
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

Deep Brain Stimulation (DBS) for the Suppression of Tremor

NCT02087046
View directory record Official record
Conditions
Tremor, Action Tremor, Essential Tremor, Tremor, Limb
Interventions
ANS Totally Implantable Deep Brain Stimulation System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
12
States / cities
Birmingham, Alabama • Loma Linda, California • Pasadena, California + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

Pilot Study of the Felix System in Patients With Essential Tremor and Parkinson's Tremor

NCT05842434
View directory record Official record
Conditions
Essential Tremor, Parkinson Disease
Interventions
Felix NeuroAI Wristband
Device
Lead sponsor
Fasikl Inc.
Industry
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
Boca Raton, Florida • Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 21, 2026, 7:41 PM EDT
Active, not recruiting Not applicable Interventional

Evaluating the Efficacy of Voice Therapy for Neurogenic Voice Disorders

NCT07474740
View directory record Official record
Conditions
Speakers With Neurogenic Voice Disorders
Interventions
Breathy voice
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 2 Interventional Results available

Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor

NCT00102596
View directory record Official record
Conditions
Essential Tremor
Interventions
1-Octanol
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
21 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 31, 2012 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 1Phase 2 Interventional

Efficacy of Levetiracetam in Essential Tremor

NCT00620165
View directory record Official record
Conditions
Essential Tremor
Interventions
levetiracetam, placebo
Drug
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
25 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2009 · Synced Sep 21, 2026, 7:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor

NCT03041714
View directory record Official record
Conditions
Essential Tremor, Cervical Dystonia, Focal Dystonia
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Sep 21, 2026, 7:41 PM EDT
Recruiting Not applicable Interventional

Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control

NCT07056361
View directory record Official record
Conditions
Movement Disorders (Incl Parkinsonism), Stroke, Traumatic Brain Injury, Brain Diseases, Parkinson Disease, Essential Tremor, Movement Disorders
Interventions
Direct cortical stimulation and deep brain stimulation of motor thalamus
Device
Lead sponsor
Jorge Gonzalez-Martinez
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 21, 2026, 7:41 PM EDT
Recruiting Phase 2 Interventional

Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Essential Tremor

NCT07673107
View directory record Official record
Conditions
Upper Limb Essential Tremor
Interventions
AGN-151607-DP, Placebo for AGN-151607-DP
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 85 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Fresno, California • Boca Raton, Florida • Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 2 Interventional Results available

A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)

NCT05122650
View directory record Official record
Conditions
Essential Tremor
Interventions
JZP385, Placebo
Drug · Other
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years to 80 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
41
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 33 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 21, 2026, 7:41 PM EDT
Recruiting No phase listed Observational

Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease

NCT07428447
View directory record Official record
Conditions
Essential Tremor, Movement Disorders, Essential Tremor, Essential Tremor-plus
Interventions
Not listed
Lead sponsor
CND Life Sciences
Other
Eligibility
50 Years to 85 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
4
States / cities
Scottsdale, Arizona • Orlando, Florida • Louisville, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 2 Interventional Results available

Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor

NCT00598078
View directory record Official record
Conditions
Essential Tremor
Interventions
Sodium Oxybate, Placebo
Drug · Other
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
50 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Bingham Farms, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 22, 2012 · Synced Sep 21, 2026, 7:41 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor

NCT05366751
View directory record Official record
Conditions
Essential Tremor
Interventions
SAGE-324
Drug
Lead sponsor
Sage Therapeutics
Industry
Eligibility
18 Years to 80 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
38
States / cities
Hoover, Alabama • Scottsdale, Arizona • Fountain Valley, California + 32 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 2 Interventional Results available

A Clinical Study to Evaluate CAD-1883 in Essential Tremor

NCT03688685
View directory record Official record
Conditions
Essential Tremor
Interventions
CAD-1883
Drug
Lead sponsor
Cadent Therapeutics
Industry
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
7
States / cities
Anniston, Alabama • Rogers, Arkansas • San Diego, California + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Sep 21, 2026, 7:41 PM EDT
Active, not recruiting Phase 3 Interventional

Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)

NCT06087276
View directory record Official record
Conditions
Essential Tremor
Interventions
60 mg ulixacaltamide, Placebo
Drug
Lead sponsor
Praxis Precision Medicines
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 21, 2026, 7:41 PM EDT
Not listed Phase 3 Interventional

Two Separate But Identical Studies Evaluating the Safety and Efficacy of ALTROPANE® in the Use of SPECT Imaging for Upper Extremity Tremor

NCT00724906
View directory record Official record
Conditions
Parkinsonian Syndromes
Interventions
123 I - ALTROPANE®
Drug
Lead sponsor
Alseres Pharmaceuticals, Inc
Industry
Eligibility
40 Years to 80 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Hopkinton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2010 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles vs. Flexor Muscles Alone for Treatment of Essential Hand Tremor(FLEX-D ET)

NCT02909907
View directory record Official record
Conditions
Essential Tremor
Interventions
Botulinum toxin, Placebo
Drug · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 7, 2019 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 2 Interventional Results available

Evaluate SAGE-547 in Participants With Essential Tremor

NCT02277106
View directory record Official record
Conditions
Essential Tremor
Interventions
SAGE-547, Placebo
Drug
Lead sponsor
Sage Therapeutics
Industry
Eligibility
35 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Bingham Farms, Michigan • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Sep 21, 2026, 7:41 PM EDT
Completed Phase 2 Interventional

A Clinical Trial of 2 Doses of PRAX-944 in Participants With Essential Tremor

NCT05021991
View directory record Official record
Conditions
Essential Tremor
Interventions
100 mg PRAX-944, 60 mg PRAX-944, Placebo, Flexibly dosed 20 mg to 100 mg PRAX-944
Drug
Lead sponsor
Praxis Precision Medicines
Industry
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
35
States / cities
Birmingham, Alabama • Little Rock, Arkansas • San Diego, California + 31 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Sep 21, 2026, 7:41 PM EDT