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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: First Trimester Pregnancy Clear all
Completed Not applicable Interventional Accepts healthy volunteers

4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions

NCT00121329
View directory record Official record
Conditions
Pain
Interventions
Intrauterine lidocaine infusion 4%
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 2004
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 20, 2005 · Synced Sep 21, 2026, 6:34 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Early Pregnancy Evaluation by Three-Dimensional Ultrasound

NCT00342290
View directory record Official record
Conditions
First Trimester Bleeding, Pregnancy
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
15 Years and older · Female only
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2012
U.S. locations
2
States / cities
Detroit, Michigan • Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 21, 2026, 6:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Iron Parameters in Non-anemic First Trimester Gravidas

NCT03670537
View directory record Official record
Conditions
Iron Deficiency (Without Anemia), Pregnancy
Interventions
Iron parameters
Diagnostic Test
Lead sponsor
Auerbach Hematology Oncology Associates P C
Other
Eligibility
Female only
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Sep 21, 2026, 6:34 PM EDT
Completed No phase listed Observational

First Trimester Prediction of Preeclampsia and Fetal Growth Restriction

NCT02379494
View directory record Official record
Conditions
Preeclampsia, Fetal Growth Restriction
Interventions
Not listed
Lead sponsor
Fetal Medicine Foundation
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional

Manual Versus Electric Vacuum Aspiration for Pregnancy Termination Between 10-14 Weeks

NCT03079622
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Electric Vacuum Aspiration, Manual Vacuum Aspiration
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Sep 21, 2026, 6:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assessment of the Number of Umbilical Cord Vessels at the Time of Nuchal Translucency Screening

NCT01367132
View directory record Official record
Conditions
Umbilical Cord
Interventions
Doppler ultrasound
Procedure
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 21, 2013 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of an Algorithm to Determine IV Sedation Dosing During First-trimester Surgical Abortion

NCT01994317
View directory record Official record
Conditions
Pregnancy, Unplanned
Interventions
Algorithm, Standard care
Other
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 16, 2015 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Study of Immediate Start of Progestin Contraceptives in Medical Abortion

NCT01902485
View directory record Official record
Conditions
Contraception
Interventions
Timing of Contraceptive Initiation in Medical Abortion
Other
Lead sponsor
Gynuity Health Projects
Other
Eligibility
Female only
Enrollment
937 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
6
States / cities
Chula Vista, California • Eureka, California • Stamford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Sep 21, 2026, 6:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient Preferences in Anesthesia for Abortion Care

NCT03030443
View directory record Official record
Conditions
Pregnancy Termination in First Trimester
Interventions
Not listed
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Sep 21, 2026, 6:34 PM EDT
Recruiting Not applicable Interventional

Alternate Nostril Breathing (ANB) for 1st Trimester Nausea and Vomiting

NCT07378839
View directory record Official record
Conditions
Pregnancy Emesis, Nausea
Interventions
Alternate Nostril Breathing
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

An Interactive Informed Consent and Education Program for Pregnant Women

NCT01176019
View directory record Official record
Conditions
Pregnancy, Down Syndrome
Interventions
Information about Prenatal Screening and Diagnosis
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 6, 2014 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Auriculotherapy - Pain Management of Aspiration Abortion

NCT03896022
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Acupressure with Beads, Acupuncture with Needles, Placebo Adhesive Disks
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
177 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2021 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Acupuncture for Pain Management During Uterine Aspiration

NCT03391986
View directory record Official record
Conditions
Pain Acute, Acupuncture
Interventions
SEIRIN® Pyonex™ Acupuncture Needles, 12 mm Plasters
Device · Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 2, 2019 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Management With Medication Abortion Through 70 Days' Gestation

NCT03925129
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
high frequency TENS treatment, Sham TENS treatment
Device
Lead sponsor
Planned Parenthood of Greater New York
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 21, 2021 · Synced Sep 21, 2026, 6:34 PM EDT
Recruiting Not applicable Interventional

Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion

NCT07288047
View directory record Official record
Conditions
Abortion, First Trimester, Pain Management, Pain After Surgery, Satisfaction, Satisfaction With Care, Anxiety After Surgery
Interventions
VR headset, Usual Care
Device · Other
Lead sponsor
Study Investigator
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 21, 2026, 6:34 PM EDT
Completed No phase listed Observational

Early Pregnancy Antioxidant Supplementation in the Prevention of Preeclampsia

NCT00583635
View directory record Official record
Conditions
Preeclampsia, Pregnancy Loss
Interventions
Not listed
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
684 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 4, 2012 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacist Provision of Medication Abortion

NCT04956731
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Pharmacist Provision of Medication Abortion
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2024 · Synced Sep 21, 2026, 6:34 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters

NCT00006445
View directory record Official record
Conditions
Down Syndrome, Chromosome Abnormalities
Interventions
Ultrasound, Serum screen
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
16 Years to 45 Years · Female only
Enrollment
38,000 participants
Healthy volunteers
Accepts healthy volunteers
U.S. locations
10
States / cities
Denver, Colorado • Boston, Massachusetts • Royal Oak, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 21, 2007 · Synced Sep 21, 2026, 6:34 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Mifepristone vs Misoprostol

NCT06502158
View directory record Official record
Conditions
Cervical Preparation
Interventions
Mifepristone, Misoprostol
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

CCT-102 or Expectant Management in Delayed Pregnancy Loss

NCT06121063
View directory record Official record
Conditions
Early Pregnancy Loss, Delayed Pregnancy Loss
Interventions
CCT-102 A and CCT-102 B
Combination Product
Lead sponsor
Conceptra Biosciences, LLC
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
15
States / cities
Tucson, Arizona • San Fernando, California • Panama City, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion

NCT03480009
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone
Drug
Lead sponsor
Study Investigator-Sponsor
Other
Eligibility
18 Years and older · Female only
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Sep 21, 2026, 6:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk

NCT00572793
View directory record Official record
Conditions
Preeclampsia
Interventions
Not listed
Lead sponsor
Carl Weiner, MD
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
431 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 7, 2015 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 4 Interventional Results available

Hydrocodone For Pain Control in First Trimester Surgical Abortion

NCT01330459
View directory record Official record
Conditions
Pain
Interventions
Hydrocodone/acetaminophen, Placebo, Ibuprofen, Lorazepam, Lidocaine
Drug
Lead sponsor
Elizabeth Micks
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Sep 21, 2026, 6:34 PM EDT
Terminated Not applicable Interventional

Choice of Modality of Follow up for Medication Abortion

NCT04056637
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Choice of follow-up option, Multi-level pregnancy test
Other · Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 27, 2020 · Synced Sep 21, 2026, 6:34 PM EDT