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Showing 25–44 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gastrointestinal Perforation Clear all
Completed Phase 2 Interventional Results available

Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies

NCT01674478
View directory record Official record
Conditions
Prematurity, Intestine Perforation, Necrotizing Enterocolitis (NEC), Short Bowel Syndrome (SBS)
Interventions
Microlipid with fish oil, Microlipid
Dietary Supplement
Lead sponsor
Wake Forest University
Other
Eligibility
1 Day to 2 Months
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 3, 2018 · Synced Sep 27, 2026, 9:26 AM EDT
Active, not recruiting Phase 2 Interventional

Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis

NCT04039750
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
antibiotic rinse with suction, suction only
Drug · Procedure
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
0 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Phase 4 Interventional Results available

Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection

NCT00195351
View directory record Official record
Conditions
Appendicitis, Cholecystitis, Cross Infection, Diverticulitis, Peritonitis
Interventions
tigecycline, ceftriaxone sodium + metronidazole
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
18 Years and older
Enrollment
467 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
46
States / cities
Mobile, Alabama • Laguna Hills, California • Los Angeles, California + 38 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2013 · Synced Sep 27, 2026, 9:26 AM EDT
Recruiting Not applicable Interventional

Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis

NCT06948071
View directory record Official record
Conditions
Appendicitis Acute, Appendicitis Perforated, Appendicitis With Perforation, Appendicitis Suppurative, Appendicitis Gangrenous
Interventions
Discharge on oral antibiotics
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Not applicable Interventional Results available

Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis

NCT04529980
View directory record Official record
Conditions
Appendicitis, Appendicitis; Perforation
Interventions
Lactobacillus rhamnosus GG (LGG) Probiotic, Placebo
Dietary Supplement
Lead sponsor
Children's Health
Other
Eligibility
4 Years to 18 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Not applicable Interventional

Evaluation of the Ability to Detect Bowel Gas During Laparoscopic Surgery

NCT02679118
View directory record Official record
Conditions
Intestinal Perforation
Interventions
Sentire
Device
Lead sponsor
Dan E. Azagury
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2017 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Phase 2 Interventional Results available

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus

NCT01958320
View directory record Official record
Conditions
Patent Ductus Arteriosus, Surgery, Necrotizing Enterocolitis, Intestinal Perforation
Interventions
pharmacologic treatment of the PDA, no pharmacologic treatment of the PDA, NSAID
Other · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
5 Days to 14 Days
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
13
States / cities
San Diego, California • San Francisco, California • San Jose, California + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Sep 27, 2026, 9:26 AM EDT
Completed No phase listed Observational

Observational Study of Surgical Treatment of Necrotizing Enterocolotis

NCT01223261
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Enterocolitis, Necrotizing, Intestinal Perforation
Interventions
Not listed
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 6 Weeks
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
17
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 13 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2019 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Not applicable Interventional

Early Versus Delayed Operation for Perforated Appendicitis

NCT00414375
View directory record Official record
Conditions
Appendiceal Abscess
Interventions
Operation on Admission, Drainage and Interval Appendectomy
Procedure
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
Up to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 2, 2009 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Not applicable Interventional Results available

The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis

NCT02881996
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
IV tylenol, No IV tylenol, Ketorolac
Drug
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
2 Years to 17 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Sep 27, 2026, 9:26 AM EDT
Not listed Not applicable Interventional

The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations

NCT04253899
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Appendectomy, Observation
Procedure · Other
Lead sponsor
Marshall University
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Sep 27, 2026, 9:26 AM EDT
Not listed Not applicable Interventional

Endoscopic Treatment of Intestinal Fistulas and Perforations

NCT00835458
View directory record Official record
Conditions
Gastric Fistula
Interventions
gastro-gastric fistula closure
Procedure
Lead sponsor
Legacy Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 10, 2009 · Synced Sep 27, 2026, 9:26 AM EDT
Terminated Not applicable Interventional

Initial Versus Delayed Operation for Treatment of Complicated Appendicitis In Children

NCT00540189
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Initial appendectomy, Interval appendectomy
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
2 Years to 17 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 18, 2016 · Synced Sep 27, 2026, 9:26 AM EDT
Not listed Phase 1 Interventional

Endoscopic Treatment of Intestinal Fistulas and Perforations

NCT01303653
View directory record Official record
Conditions
Gastrointestinal Fistula, Gastrointestinal Perforation
Interventions
endoscopic closure of gastrointestinal fistulas and perforations
Procedure
Lead sponsor
The Oregon Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 27, 2011 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Phase 4 Interventional Results available

Optimal Care of Complicated Appendicitis

NCT03159754
View directory record Official record
Conditions
Appendicitis, Perforated Appendicitis, Ruptured Appendicitis, Complicated Appendicitis
Interventions
Early Appendectomy, Interval Appendectomy, Antibiotics
Procedure · Drug
Lead sponsor
University of Michigan
Other
Eligibility
5 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Not applicable Interventional Results available

Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis

NCT01029353
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Enterocolitis, Necrotizing, Intestinal Perforation
Interventions
Laparotomy, Drainage
Procedure
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 8 Weeks
Enrollment
529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
22
States / cities
Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Sep 27, 2026, 9:26 AM EDT
Completed Not applicable Interventional Results available

Feasibility of Translumenal Endoscopic Omental Patch Closure of Perforated Viscus

NCT01080326
View directory record Official record
Conditions
Peptic Ulcer
Interventions
Endoscopic Translumenal Omental Patch
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Sep 27, 2026, 9:26 AM EDT
Not yet recruiting Phase 4 Interventional

Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study

NCT04200729
View directory record Official record
Conditions
Acute, Perforated Appendicitis
Interventions
Irrigation with PVI, Usual care
Drug · Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
2 Years to 17 Years
Enrollment
1,750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Sep 27, 2026, 9:26 AM EDT
Completed No phase listed Observational

Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis

NCT00195923
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Ampicillin, gentamicin, clindamycin, flagyl, ceftazidime
Drug
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
1 Month to 18 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 5, 2007 · Synced Sep 27, 2026, 9:26 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

IRT in Infants With Intestinal Perforation

NCT01530828
View directory record Official record
Conditions
Intestinal Perforation, Necrotizing Enterocolitis
Interventions
Not listed
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
1 Day to 16 Days
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 8, 2013 · Synced Sep 27, 2026, 9:26 AM EDT