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Showing 1–13 of 13 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Great Saphenous Vein Insufficiency Clear all
Terminated Not applicable Interventional Results available

VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

NCT03820947
View directory record Official record
Conditions
Venous Reflux
Interventions
VenaSeal™ System, Endothermal Ablation (ETA), Surgical Stripping
Device · Procedure
Lead sponsor
Medtronic Endovascular
Industry
Eligibility
18 Years and older
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
12
States / cities
Prescott Valley, Arizona • Tucson, Arizona • Fresno, California + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Not applicable Interventional

Minimally Invasive Treatment of Primary Great Saphenous Vein (GSV) Insufficiency Using High Intensity Focused Ultrasound (HIFU)

NCT05193643
View directory record Official record
Conditions
Great Saphenous Vein Insufficiency
Interventions
Sonovein Treatment
Device
Lead sponsor
Englewood Hospital and Medical Center
Other
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Englewood, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Phase 3 Interventional Results available

Endovenous Ablation With and Without Polidocanol Endovenous Microfoam Treatment for Patients With Great Saphenous Vein Incompetence and Visible Varicosities

NCT01197833
View directory record Official record
Conditions
Great Saphenous Vein Incompetence, Visible Varicosities
Interventions
endovenous ablation+polidocanol injectable microfoam 0.125%, Endovenous ablation+polidocanol injectable microfoam 1.0%, Endovenous ablation+polidocanol injectable foam 2.0%
Drug
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
7
States / cities
Scottsdale, Arizona • Bradenton, Florida • Oak Brook, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Jul 22, 2026, 2:21 AM EDT
Terminated Phase 4 Interventional Results available

Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein

NCT02248740
View directory record Official record
Conditions
Chronic Venous Insufficiency
Interventions
Ablation of the incompetent small saphenous vein
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 6, 2019 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Phase 4 Interventional

Apixaban vs Rivaroxaban vs No Anticoagulant to Prevent EHIT After Great Saphenous Vein Laser Ablation

NCT07699796
View directory record Official record
Conditions
Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral), Varicose Veins Leg, Venous Thrombosis
Interventions
Apixaban, Rivaroxaban
Drug
Lead sponsor
Heart, Artery, and Vein Center of Fresno
Other
Eligibility
18 Years and older
Enrollment
564 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Phase 1 Interventional Results available

Pharmacokinetic Study of Polidocanol Endovenous Microfoam (PEM)

NCT01428076
View directory record Official record
Conditions
Varicose Veins
Interventions
Polidocanol Endovenous Microfoam (PEM)
Drug
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Bradenton, Florida
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Jul 22, 2026, 2:21 AM EDT
Active, not recruiting Not applicable Interventional

Venclose digiRF System Post Market Study

NCT05504070
View directory record Official record
Conditions
Venous Reflux, Chronic Venous Insufficiency
Interventions
Venclose System (digiRF generator w EVSRF catheter), Venclose MAVEN System (digiRF generator w MAVEN catheter)
Device
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
7
States / cities
Thornton, Colorado • Kailua, Hawaii • Roseville, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 22, 2026, 2:21 AM EDT
Withdrawn Not applicable Interventional

Comparison Study for Safety and Efficacy of Two Devices for the Treatment of the Great Saphenous Vein

NCT01173419
View directory record Official record
Conditions
Varicose Veins, Venous Insufficiency
Interventions
VNUS RF ClosureFAST, VenaCure EVLT NeverTouch
Device
Lead sponsor
Angiodynamics, Inc.
Industry
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
6
States / cities
Sacramento, California • Bradenton, Florida • Melrose Park, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2012 · Synced Jul 22, 2026, 2:21 AM EDT
Completed No phase listed Observational

Retrospective Review of Saphenous Vein Incompetence: Venaseal Versus Endovenous Thermal Ablation

NCT04006184
View directory record Official record
Conditions
Varicose Veins, Venous Reflux, Venous Insufficiency
Interventions
Chart review
Other
Lead sponsor
Lake Washington Vascular
Other
Eligibility
18 Years and older
Enrollment
547 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Oct 2, 2019 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Not applicable Interventional

Extracorporeal Flow Abolition in Relation With Primary Insufficiency of Great Saphenous Veins (GSV) Using High Intensity Focused Ultrasound (HIFU) Generated by Sonovein: A Multi Center Prospective Pivotal Study

NCT05926830
View directory record Official record
Conditions
Chronic Venous Insufficiency
Interventions
Sonovein Treatment
Device
Lead sponsor
Theraclion
Industry
Eligibility
22 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Englewood, New Jersey • Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lake Washington Vascular VenaSeal™ Post-Market Evaluation (WAVES)

NCT02585726
View directory record Official record
Conditions
Venous Reflux
Interventions
SP-402 VenaSeal™ Closure System
Device
Lead sponsor
Lake Washington Vascular
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Mar 15, 2018 · Synced Jul 22, 2026, 2:21 AM EDT
Terminated Phase 4 Interventional Results available

Varithena Versus Endothermal Ablation of the Great Saphenous Vein (VERITAS)

NCT05312970
View directory record Official record
Conditions
Varicose Veins
Interventions
Varithena®, FDA-approved Endothermal Ablation (ETA) systems
Drug · Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
9
States / cities
Darien, Connecticut • Washington D.C., District of Columbia • Houma, Louisiana + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Phase 4 Interventional Results available

Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein

NCT02236338
View directory record Official record
Conditions
Chronic Venous Insufficiency
Interventions
Ablation of the Incompetent Greater Saphenous Vein, ClosureFAST radiofrequency catheter, EVLT 980nm diode laser system
Procedure · Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 13, 2018 · Synced Jul 22, 2026, 2:21 AM EDT