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ClinicalTrials.gov public records Last synced Sep 30, 2026, 2:45 AM EDT

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Showing 1–24 of 230 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: HFpEF - Heart Failure With Preserved Ejection Fraction Clear all
Withdrawn No phase listed Observational Accepts healthy volunteers

The Role of Gut Microbiota in Heart Failure and Pre-Heart Failure With Preserved Ejection Fraction

NCT02728154
View directory record Official record
Conditions
Heart Failure
Interventions
Blood Sample, Stool Sample
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2025
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Sep 30, 2026, 2:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

UTSW HP [13-C] Pyruvate Injection in HCM

NCT03057002
View directory record Official record
Conditions
Cardiomyopathy, Hypertrophic, Dilated Cardiomyopathy, Duchenne Muscular Dystrophy, Cardiac Sarcoidosis, Becker Muscular Dystrophy, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction
Interventions
Hyperpolarized 13C-Pyruvate
Diagnostic Test
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Sep 30, 2026, 2:45 AM EDT
Withdrawn Phase 4 Interventional

Polydiuretic Therapy for Heart Failure With Preserved Ejection Fraction and Diabetes Mellitus

NCT04697485
View directory record Official record
Conditions
HF - Heart Failure, Diabetes Mellitus
Interventions
Bumetanide 0.5 mg, dapaglifozin 5 mg, eplerenone 25 mg
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Sep 30, 2026, 2:45 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Assess the Relative Bioavailability and Safety of Different Formulations of AZD4831 in Fasted State in Healthy Volunteers.

NCT05457270
View directory record Official record
Conditions
Healthy Volunteers
Interventions
AZD4831
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Brooklyn, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Sep 30, 2026, 2:45 AM EDT
Recruiting Not applicable Interventional

Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)

NCT06337812
View directory record Official record
Conditions
Type2diabetes, Heart Failure With Preserved Ejection Fraction
Interventions
Potato Starch
Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 24, 2025 · Synced Sep 30, 2026, 2:45 AM EDT
Completed Phase 2 Interventional Results available

Acute Effects of Exogenous Ketone Ester Administration in Heart Failure

NCT04633460
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction
Interventions
Ketone ester, placebo drink
Dietary Supplement
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 85 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 27, 2024 · Synced Sep 30, 2026, 2:45 AM EDT
Completed Early Phase 1 Interventional Results available

Treatment of HFpEF With Nitrate Supplement

NCT03289481
View directory record Official record
Conditions
Heart Failure With Normal Ejection Fraction
Interventions
Active lozenge, Placebo
Dietary Supplement · Drug
Lead sponsor
MaineHealth
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rockport, Maine
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Sep 30, 2026, 2:45 AM EDT
Recruiting Not applicable Interventional

Inspiratory Muscle Training in HFpEF

NCT06510231
View directory record Official record
Conditions
Heart Failure
Interventions
Inspiratory Muscle Training
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Completed No phase listed Observational

Readmission Risk Factors and Heart Failure With Preserved Ejection Fraction

NCT04008914
View directory record Official record
Conditions
Heart Failure, Preserved Ejection Fraction
Interventions
retrospective observation
Other
Lead sponsor
Ascension Macomb-Oakland Hospital
Other
Eligibility
Not listed
Enrollment
492 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Warren, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 8, 2019 · Synced Sep 30, 2026, 2:45 AM EDT
Recruiting Not applicable Interventional

Home-Based Cardiac Rehabilitation for Patients With Heart Failure

NCT06479876
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Cardiovascular Diseases
Interventions
HBCR
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Sep 30, 2026, 2:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assessment of Cardiac Functional Reserve in Heart Failure With Preserved Ejection Fraction (HF-PEF)

NCT00585806
View directory record Official record
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Sep 30, 2026, 2:45 AM EDT
Terminated Not applicable Interventional Results available

Adherence to ASV Therapy in Heart Failure With Preserved Ejection Fraction Feasibility Study

NCT03195660
View directory record Official record
Conditions
Heart Failure With Normal Ejection Fraction, Sleep Apnea
Interventions
ASV Therapy
Device
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
3
States / cities
San Diego, California • Philadelphia, Pennsylvania • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated May 14, 2021 · Synced Sep 30, 2026, 2:45 AM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure With Preserved Ejection Fraction

NCT03465072
View directory record Official record
Conditions
Heart Failure With Normal Ejection Fraction
Interventions
Exercise training
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
65 Years to 85 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

HEART Camp Connect -Promoting Exercise in Adults With Heart Failure With Preserved Ejection Fraction

NCT05784753
View directory record Official record
Conditions
HFpEF - Heart Failure With Preserved Ejection Fraction
Interventions
HEART Camp, HEART Camp Connect
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
3
States / cities
Detroit, Michigan • Omaha, Nebraska • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Understanding the Mechanisms of Diastolic Dysfunction

NCT03340233
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Healthy
Interventions
MRI (cardiac) off-label use gadolinium contrast (IND exempt), MRI (cardiac)
Diagnostic Test
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Sep 30, 2026, 2:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

External Body Pressure in Heart Failure With Preserved Ejection Fraction

NCT05764564
View directory record Official record
Conditions
Heart Failure, Diastolic
Interventions
Positive or negative pressure
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
30 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Active, not recruiting Phase 2 Interventional

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

NCT06616974
View directory record Official record
Conditions
Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction
Interventions
TX000045- Dose A, TX000045- Dose B, Placebo
Drug
Lead sponsor
Tectonic Therapeutic
Industry
Eligibility
18 Years to 83 Years
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
25
States / cities
Phoenix, Arizona • Scottsdale, Arizona • San Francisco, California + 21 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Completed No phase listed Observational

WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise

NCT06576050
View directory record Official record
Conditions
Heart Failure, Obesity, Weight Loss, Heart Failure With Preserved Ejection Fraction
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Completed No phase listed Observational

Emulation of the SUMMIT Heart Failure Trial in Healthcare Claims Data

NCT06914154
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Heart Failure With Preserved Ejection Fraction (HFPEF)
Interventions
Tirzepatide, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
40 Years and older
Enrollment
11,265 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Completed Phase 2 Interventional Results available

A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16)

NCT04945460
View directory record Official record
Conditions
Hypertension, Pulmonary
Interventions
Sotatercept 0.3 mg/kg, Placebo, Sotatercept 0.3 mg/kg escalating to 0.7 mg/kg
Drug
Lead sponsor
Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
Industry
Eligibility
18 Years to 85 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
56
States / cities
Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 46 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Completed Phase 2 Interventional

Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)

NCT06215586
View directory record Official record
Conditions
Heart Failure, Heart Failure Preserved Ejection Fraction, Cardiovascular Diseases, Heart Diseases
Interventions
Tovinontrine (CRD-750), Placebo
Drug
Lead sponsor
Cardurion Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
22
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Orange, California + 19 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 30, 2026, 2:45 AM EDT
Completed No phase listed Observational

Classification of Heart Failure With Preserved Ejection Fraction

NCT01030991
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Diastolic Heart Failure
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
21 Years and older
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Sep 30, 2026, 2:45 AM EDT
Completed Phase 2 Interventional Results available

Vasodilator Therapy for Heart Failure and Preserved Ejection Fraction

NCT01516346
View directory record Official record
Conditions
Heart Failure, Congestive Heart Failure
Interventions
Isosorbide Dinitrate, Isosorbide Dinitrate + Hydralazine, Placebo
Drug
Lead sponsor
Corporal Michael J. Crescenz VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 21, 2022 · Synced Sep 30, 2026, 2:45 AM EDT
Recruiting Phase 2 Interventional

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

NCT06979362
View directory record Official record
Conditions
Heart Failure
Interventions
CDR132L, Placebo
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
40 Years to 84 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
29
States / cities
Birmingham, Alabama • Tucson, Arizona • Covina, California + 24 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 30, 2026, 2:45 AM EDT