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Showing 1–24 of 91 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Headache Disorders, Secondary Clear all
Terminated Phase 1 Interventional

Effects of Psilocybin in Concussion Headache

NCT03806985
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Placebo oral capsule, Low Dose Psilocybin, High Dose Psilocybin
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Phase 3 Interventional Results available

Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines

NCT00122278
View directory record Official record
Conditions
Migraine
Interventions
Dexamethasone, Placebo
Drug · Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
3
States / cities
Manhattan, New York • New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 12, 2018 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Phase 4 Interventional Results available

Dexamethasone for Post Traumatic Headache

NCT04799015
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Dexamethasone, Metoclopramide 10mg
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
16 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Not applicable Interventional Results available

Adjunct VR Pain Management in Acute Brain Injury

NCT04356963
View directory record Official record
Conditions
Traumatic Brain Injury, Headaches Posttraumatic, Trauma, Pain, Acute
Interventions
Virtual Reality Session (VR Blu), Tablet-based Session (Tablet Blu), Use of Virtual Reality Head Mounted Display without Content (VR Blank)
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 23, 2023 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Art Therapy QEEG Study for Service Members with a Traumatic Brain Injury and Posttraumatic Stress Symptoms

NCT04776304
View directory record Official record
Conditions
Post-Traumatic Headache, PTSD, TBI, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Posttraumatic Stress Disorder, Delayed Onset, Sleep Disturbance, Nightmare, Nightmares, REM-Sleep Type, Headache, Irritable Mood, Anger, Eating Disorders, Combat and Operational Stress Reaction, Combat Stress Disorders, Military Operations, Military Activity, Military Family
Interventions
Art Therapy
Behavioral
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2024 · Synced Jul 22, 2026, 6:01 PM EDT
Recruiting Not applicable Interventional

Multisite Advancement of Research on Chronic Posttraumatic Headache

NCT05620719
View directory record Official record
Conditions
Posttraumatic Headache
Interventions
Cognitive Behavioral Therapy for Posttraumatic Headache, Treatment as Usual, Telemedicine-based Cognitive Behavioral Therapy (TCBT)
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
525 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
8
States / cities
Los Angeles, California • Palo Alto, California • Honolulu, Hawaii + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Jul 22, 2026, 6:01 PM EDT
Terminated Phase 4 Interventional Results available

Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines

NCT02090998
View directory record Official record
Conditions
Transformed Migraine, Chronic Daily Headache
Interventions
SPG Block with 5% Lidocaine gel, Amitriptyline
Procedure · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 22, 2026, 6:01 PM EDT
Withdrawn Phase 2 Interventional

RCT of SPG Blocks for Post-dural Headache

NCT03560349
View directory record Official record
Conditions
Post-Dural Puncture Headache
Interventions
Lidocaine HCl Gel 2%, placebo gel
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 12, 2022 · Synced Jul 22, 2026, 6:01 PM EDT
Not listed No phase listed Observational

McKenzie Method of Mechanical Diagnosis and Therapy for Management of Cervicogenic Headache: A Prospective Case Series

NCT05212844
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Musculoskeletal Physical Therapy
Procedure
Lead sponsor
Faith Regional Health Services
Other
Eligibility
19 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Norfolk, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Jul 22, 2026, 6:01 PM EDT
Recruiting Phase 2 Interventional

Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI

NCT05049057
View directory record Official record
Conditions
Posttraumatic Headache, Mild Traumatic Brain Injury
Interventions
Erenumab 140 Mg/mL Subcutaneous Solution, Placebo
Drug
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
4
States / cities
Fort Bragg, North Carolina • Pittsburgh, Pennsylvania • El Paso, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Mobilization Versus Manipulation for the Treatment of Cervicogenic Headaches

NCT03919630
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Thrust Mobilization, Non-Thrust Mobilizations
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Havertown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Jul 22, 2026, 6:01 PM EDT
Terminated Phase 4 Interventional Results available

Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction

NCT01053507
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
sumatriptan/naproxen sodium, Placebo
Drug
Lead sponsor
Cady, Roger, M.D.
Individual
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
3
States / cities
Springfield, Missouri • Nashville, Tennessee • Temple, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Jul 22, 2026, 6:01 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache

NCT03112720
View directory record Official record
Conditions
Postdural Puncture Headache
Interventions
Epidural Blood Patch, Sphenopalatine Ganglion Block
Device · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
13 Years to 92 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Spinal Manipulation and Dry Needling Versus Conventional Physical Therapy in Patients With Cervicogenic Headache

NCT02373605
View directory record Official record
Conditions
Cervicogenic Headaches
Interventions
Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Jul 22, 2026, 6:01 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Investigate the Mechanisms, Predictors, and Prevention of Persistent Post-Traumatic Headache

NCT04369729
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
5
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Jacksonville, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jul 22, 2026, 6:01 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Correlation Between Central Sensitization Inventory and Posturographic Data

NCT03058003
View directory record Official record
Conditions
Central Nervous System Sensitization
Interventions
Posturography Evaluation, Central Sensitization Inventory
Diagnostic Test · Other
Lead sponsor
Caps Research Network
Other
Eligibility
18 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Jul 22, 2026, 6:01 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Pediatric Concussion Outcomes

NCT04226365
View directory record Official record
Conditions
Concussion Post Syndrome, Headaches Posttraumatic, Mild Traumatic Brain Injury
Interventions
Nortriptyline, Placebo
Drug
Lead sponsor
Lancaster General Hospital
Other
Eligibility
13 Years to 21 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Jul 22, 2026, 6:01 PM EDT
Terminated Not applicable Interventional

Acupuncture for Headache Post-Traumatic Brain Injury: A Feasibility Study

NCT04216173
View directory record Official record
Conditions
Post-Traumatic Headache, Traumatic Brain Injury
Interventions
Acupuncture
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 23, 2021 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Phase 4 Interventional Results available

Prazosin for Post-Concussive Headaches

NCT02965027
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Prazosin, Placebo
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
2
States / cities
Seattle, Washington • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Phase 2 Interventional Results available

Sumatriptan as Treatment for Post-traumatic Headache

NCT01854385
View directory record Official record
Conditions
Post-traumatic Headache
Interventions
Sumatriptan 100 mg
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Jul 22, 2026, 6:01 PM EDT
Terminated Not applicable Interventional

Yoga Training for Returning Veterans With Headache

NCT01993069
View directory record Official record
Conditions
Post Traumatic Headache, Chronic Daily Headache
Interventions
Iyengar-based Yoga Training
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 1, 2017 · Synced Jul 22, 2026, 6:01 PM EDT
Recruiting Not applicable Interventional

Manipulation and Dry Needling in Patients With Cervicogenic Headache and WAD II

NCT06502951
View directory record Official record
Conditions
Cervicogenic Headache, Whiplash Injuries
Interventions
Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated May 10, 2025 · Synced Jul 22, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Thoracic Spine Thrust Manipulation for Cervicogenic Headaches: A Randomized Clinical Trial

NCT02708953
View directory record Official record
Conditions
Headache Disorders, Secondary
Interventions
Thoracic manipulation (Manipulation Group), Thoracic Manipulation (Control wait-list)
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Jul 22, 2026, 6:01 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Multi Cervical Unit Measures of Cervical Isometric Strength and Range of Motion: A Pilot Study

NCT00510757
View directory record Official record
Conditions
Cervicogenic Headache, Neck Pain, Whiplash, Kyphotic and Reversed Cervical Curves
Interventions
Not listed
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 16, 2008 · Synced Jul 22, 2026, 6:01 PM EDT