- Conditions
- Aortic Valve Stenosis
- Interventions
- Aortic valve replacement
- Device
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2015
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
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Showing 1–16
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- Conditions
- Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Hypertrophic Cardiomyopathy, Tricuspid Valve Insufficiency
- Interventions
- Blood Draw
- Procedure
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 378 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2010 – 2020
- U.S. locations
- 1
- States / cities
- Jacksonville, Florida
- Conditions
- Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death
- Interventions
- Electroanatomic substrate mapping
- Diagnostic Test
- Lead sponsor
- Boston Children's Hospital
- Other
- Eligibility
- Not listed
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Aortic Valve Stenosis, Aortic Valve Regurgitation, Prosthesis Failure
- Interventions
- Doppler-echocardiography, Invasive hemodynamic measurements
- Procedure
- Lead sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 310 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2029
- U.S. locations
- 6
- States / cities
- San Francisco, California • Hollywood, Florida • Royal Oak, Michigan + 3 more
- Conditions
- Heart Valve Disease
- Interventions
- On-X valve using reduced anticoagulation, On-X Valve with Standard warfarin Therapy
- Device
- Lead sponsor
- On-X Life Technologies, Inc.
- Industry
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 977 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2023
- U.S. locations
- 44
- States / cities
- Tucson, Arizona • Loma Linda, California • Hartford, Connecticut + 34 more
- Conditions
- Thrombotic and Bleeding Events
- Interventions
- On-X Aortic Heart Valve replacement
- Device
- Lead sponsor
- On-X Life Technologies, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 510 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2027
- U.S. locations
- 15
- States / cities
- Tucson, Arizona • Hartford, Connecticut • Indianapolis, Indiana + 12 more
- Conditions
- Atrial Fibrillation, Atrial Flutter, Venous Thromboembolic Disease, Myocardial Infarction, Cardiomyopathy
- Interventions
- ATI-5923, Coumadin (warfarin)
- Drug
- Lead sponsor
- ARYx Therapeutics
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 600 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2009
- U.S. locations
- 41
- States / cities
- Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 34 more
- Conditions
- Coronary Disease, Heart Valve Diseases
- Interventions
- CTI-01 (ethyl pyruvate)
- Drug
- Lead sponsor
- Critical Therapeutics
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 150 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2006
- U.S. locations
- 17
- States / cities
- Laguna Hills, California • Los Angeles, California • San Francisco, California + 14 more
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Dilated Cardiomyopathies
- Interventions
- Financial Incentive and Med-eMonitor, 2Med-eMonitor
- Behavioral · Device
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 268 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2013
- U.S. locations
- 2
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Aortic Valve Stenosis, Implantation, Heart Valve Prosthesis
- Interventions
- Transcatheter aortic valve replacement (Edwards Sapien Ultra or Medtronic Evolut Pro
- Device
- Lead sponsor
- Marvin Eng
- Other
- Eligibility
- Not listed
- Enrollment
- 150 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2025
- U.S. locations
- 3
- States / cities
- Phoenix, Arizona • Tucson, Arizona • Delray Beach, Florida
- Conditions
- Heart Valve Disease
- Interventions
- On-X Heart valve replacement, SJM Heart valve replacement
- Device
- Lead sponsor
- On-X Life Technologies, Inc.
- Industry
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 857 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2003 – 2021
- U.S. locations
- 7
- States / cities
- Los Angeles, California • Honolulu, Hawaii • St Louis, Missouri + 3 more
- Conditions
- Aortic Valve Disease
- Interventions
- Open repair
- Device
- Lead sponsor
- JOTEC GmbH
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 108 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2029
- U.S. locations
- 3
- States / cities
- Danville, Pennsylvania • Houston, Texas • Richmond, Virginia
- Conditions
- Atrial Fibrillation, Deep Venous Thrombosis, Dilated Cardiomyopathies
- Interventions
- Lottery arm (Lottery and Med-eMonitor), Non-Lottery (Med-eMonitor only)
- Behavioral
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 101 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2009
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Pregnancy, Anticoagulation, Prosthetic Heart Valves
- Interventions
- Not listed
- Lead sponsor
- University of California, Irvine
- Other
- Eligibility
- 15 Years to 45 Years · Female only
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2002 – 2007
- U.S. locations
- 1
- States / cities
- Long Beach, California
- Conditions
- Heart Valve Prosthesis
- Interventions
- INSPIRIS Resilia (model 11500A)
- Device
- Lead sponsor
- Baylor College of Medicine
- Other
- Eligibility
- 0 Years to 64 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2025
- U.S. locations
- 1
- States / cities
- San Antonio, Texas
- Conditions
- Eisenmenger Syndrome
- Interventions
- Transcather Valve Implantation
- Device
- Lead sponsor
- University of California, Los Angeles
- Other
- Eligibility
- Not listed
- Enrollment
- 90 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2018
- U.S. locations
- 1
- States / cities
- Los Angeles, California