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ClinicalTrials.gov public records Last synced Nov 14, 2026, 7:36 PM EST

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Showing 1–24 of 90 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Hypoxic Ischemic Encephalopathy Clear all

Conditions: Neonatal Seizure, Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Seizure Newborn
Interventions: Levetiracetam Injection, Phenobarbital Sodium Injection; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: Up to 1 Month
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: San Diego, California • Minneapolis, Minnesota

Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: Holding during cooling; Other
Lead sponsor: Alexa Craig; Other
Eligibility: 24 Hours to 3 Days
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: Portland, Maine

Conditions: Hypoxia-Ischemia, Brain, Heart Arrest, Status Epilepticus, Refractory Status Epilepticus, Seizures, Anoxic-Ischemic Encephalopathy, Anoxia-Ischemia, Cerebral
Interventions: Burst Suppression EEG Target Intravenous Anesthesia, Seizure Suppression EEG Target Intravenous Anesthesia; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages, Epilepsy, Cerebral Palsy, Intellectual Disability
Interventions: Not listed
Lead sponsor: University of California, San Francisco; Other
Eligibility: 2 Years to 8 Years
Enrollment: 188 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 9
States / cities: San Francisco, California • Stanford, California • Washington D.C., District of Columbia + 5 more

Conditions: Hypoxia-Ischemia, Brain, Periventricular Leukomalacia
Interventions: Not listed
Lead sponsor: Johns Hopkins University; Other
Eligibility: Not listed
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: Developmental Outcomes; Other
Lead sponsor: University of Florida; Other
Eligibility: 18 Months to 20 Months
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Hypoxic-ischemic Encephalopathy
Interventions: Dexmedetomidine; Drug
Lead sponsor: Seattle Children's Hospital; Other
Eligibility: 1 Hour to 1 Day
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Infant, Newborn, Hypoxia-Ischemia, Brain
Interventions: Induced hypothermia, Control; Device
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Up to 6 Hours
Enrollment: 208 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2010
U.S. locations: 16
States / cities: Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 13 more

Conditions: Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy Mild
Interventions: Darbepoetin Alfa, Normal Saline; Drug
Lead sponsor: University of New Mexico; Other
Eligibility: 1 Hour to 24 Hours
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Brain Death, Anoxic Brain Injury, Cardiac Arrest, Sedative Intoxication, Narcotic Intoxication
Interventions: Flumazenil, Naloxone; Drug
Lead sponsor: Prisma Health-Midlands; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
Interventions: Cool-Cap; Device
Lead sponsor: Olympic Medical; Industry
Eligibility: 1 Hour to 6 Hours
Enrollment: 235 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2003
U.S. locations: 19
States / cities: Little Rock, Arkansas • Oakland, California • San Diego, California + 15 more

Conditions: Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy, Encephalopathy
Interventions: Visual Evoked Potential (VEP), Electroretinogram (ERG); Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: Up to 36 Months
Enrollment: 125 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2029
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Sedation, Sleep
Interventions: Continuous bedside video monitoring with AI anatomic landmark tracking for neurologic monitoring; Device
Lead sponsor: Artemis AI Labs; Industry
Eligibility: Not listed
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: New York, New York

Conditions: Neonatal Hypoxic Ischemic Encephalopathy
Interventions: infusion of autologous cord blood, Neurodevelopmental outcomes; Biological · Other
Lead sponsor: Michael Cotten; Other
Eligibility: Up to 14 Days
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic, Hypoxic-Ischemic Encephalopathy, Ischemic-Hypoxic Encephalopathy
Interventions: Hypothermia, Normothermic Control; Device · Procedure
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: 33 Weeks to 35 Weeks
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 18
States / cities: Birmingham, Alabama • Palo Alto, California • Atlanta, Georgia + 14 more

Conditions: Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
Interventions: Methylphenidate; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hypoxic Ischemic Encephalopathy
Interventions: blood sample; Procedure
Lead sponsor: University of Florida; Other
Eligibility: 1 Day to 3 Days
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy, Periventricular Leukomalacia
Interventions: Mobility Device, Spinal Stimulation; Device
Lead sponsor: University of Washington; Other
Eligibility: 4 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage, Aneurysmal Subarachnoid Hemorrhage, Vascular Dementia, Anoxic Brain Injury, Unruptured Intracranial Aneurysm, Carotid Artery Stenosis Symptomatic, Asymptomatic Carotid Artery Stenosis, Non-Aneurysmal Perimesencephalic Subarachnoid Haemorrhage, Cerebral Venous Thrombosis, Moyamoya Disease, Fibromuscular Dysplasia, Subarachnoid Hemorrhage, Leukoaraiosis, Arteriovenous Fistula, Reversible Cerebral Vasoconstriction Syndrome, CADASIL
Interventions: Not listed
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2030
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: HIE - Perinatal Hypoxic - Ischemic Encephalopathy
Interventions: NIRS; Device
Lead sponsor: Albany Medical College; Other
Eligibility: 1 Minute to 2 Years
Enrollment: 101 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Albany, New York

Conditions: HIE, TBI (Traumatic Brain Injury), TBI, Hemodynamic Instability, Hypoxic-Ischemic Encephalopathy
Interventions: MR Imaging; Diagnostic Test
Lead sponsor: Children's Hospital Los Angeles; Other
Eligibility: 1 Minute to 18 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2035
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Hypoxia-Ischemia, Brain
Interventions: taVNS; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 7 Years to 18 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Hypoxia, Brain, Hypoxia-Ischemia, Brain
Interventions: Infant stimulation; Behavioral
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: Up to 1 Month
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 1999
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Hypoxic-Ischemic Encephalopathy, Hepatitis B Vaccination, Hypothermia, Newborn
Interventions: Hypothermia Protocol; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 0 Hours to 72 Hours
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Search by objective public record fields.

A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures

Holding, Stress, and Bonding During Therapeutic Hypothermia

buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

Neonatal Seizure Registry - Developmental Functional EValuation

Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury

Developmental Outcomes

Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia

Whole-Body Cooling for Birth Asphyxia in Term Infants

Mild Encephalopathy in the Newborn Treated With Darbepoetin

Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death Determination

CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy

Healthy Little Eyes

Neonatal Neurological Observation With Video AI

Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy

Preemie Hypothermia for Neonatal Encephalopathy

Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness

Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control Levels)

Spinal Stimulation and Mobility Devices

Florida Cerebrovascular Disease Biorepository and Genomics Center

The Ability of NIRS to Predict Brain Injury in Hypoxic Ischemic Encephalopathy

Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)

Transauricular Vagus Nerve Stimulation in Children

Home Stimulation for Brain-Asphyxiated Infants

Hypothermia's Effect on Hepatitis B Vaccination