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Showing 1–24 of 108 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Intraoperative Pain Clear all
Completed Phase 4 Interventional Results available

Surgeon Infiltration QL Block Comparison

NCT03496610
View directory record Official record
Conditions
Quadratus Lumborum Block, Surgical Wound Infiltration
Interventions
Liposomal Bupivicaine, QL Block
Drug · Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries

NCT02313675
View directory record Official record
Conditions
Postoperative Pain, Carpal Tunnel Release, Distal Radius Fracture
Interventions
Acetaminophen, Ketorolac Tromethamine, Saline
Drug
Lead sponsor
John Fowler
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 3 Interventional Results available

Intraoperative Lidocaine Infusion for Postoperative Pain Management in Obese Patients

NCT01944098
View directory record Official record
Conditions
Bariatric Surgical Pain
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Jun 26, 2026, 2:31 PM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds

NCT06792474
View directory record Official record
Conditions
Spinal Disease, Anesthesia, Post Operative Pain
Interventions
Lidocaine in Saline, Normal saline
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jun 26, 2026, 2:31 PM EDT
Not listed Phase 4 Interventional

Comparing Ropivacaine Adductor Canal Blockade by Surgeon Versus Anesthesiologist

NCT03864588
View directory record Official record
Conditions
Pain, Postoperative, Satisfaction
Interventions
Ropivacaine
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 80 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Not applicable Interventional Results available

Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair

NCT02341144
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Pre-op percutaneous rectus sheath block, Intra-operative rectus sheath block, Ropivacaine
Procedure · Drug
Lead sponsor
Johns Hopkins All Children's Hospital
Other
Eligibility
3 Years to 18 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Jun 26, 2026, 2:31 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Tourniquet Pressure in Primary Total Knee Arthroplasty

NCT02830087
View directory record Official record
Conditions
Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
Interventions
Tourniquet Cuff Pressure
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Bermuda Run, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Applied Topical Heat as an Adjunct for Pain Control in First-Trimester Surgical Abortionl

NCT02536235
View directory record Official record
Conditions
Topical Heat Application for Intraoperative Abortion Pain Management
Interventions
heat
Other
Lead sponsor
Planned Parenthood of Greater New York
Other
Eligibility
16 Years to 51 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain

NCT00899600
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Ketamine, Normal saline
Drug · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Not applicable Interventional

Intraoperative Neuromonitoring Recording With a Novel SCS Paddle: Phase II

NCT05459324
View directory record Official record
Conditions
Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
Interventions
HD Study Electrode
Device
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Jun 26, 2026, 2:31 PM EDT
Not listed Not applicable Interventional

Post-op Ketamine Study

NCT03865550
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Isotonic saline, Ketamine Injectable Solution
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
Not listed
Enrollment
75 participants
Timeline
2016 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Jun 26, 2026, 2:31 PM EDT
Withdrawn No phase listed Observational

Study on the Use of Intraoperative Neurophysiological Monitoring in Spinal Cord Stimulator Trials

NCT05540756
View directory record Official record
Conditions
Pain, Chronic, Lumbar Radiculopathy, SCS
Interventions
Not listed
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Timeline
2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 3 Interventional Results available

Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Thoracic Surgery

NCT01973452
View directory record Official record
Conditions
Pain
Interventions
Dexmedetomidine, Placebo
Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
21 Years and older
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
4
States / cities
Basking Ridge, New Jersey • Commack, New York • Harrison, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 2 Interventional Results available

Open-Label CA-008 (Vocacapsaicin) in Bunionectomy

NCT03885596
View directory record Official record
Conditions
Pain
Interventions
CA-008, Ketorolac, Acetaminophen IV, Fentanyl, Bupivacaine Hydrochloride, Lidocaine HCl, Celecoxib, Acetaminophen Oral, Lidocaine Hydrochloride, Exparel
Drug
Lead sponsor
Concentric Analgesics
Industry
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Jun 26, 2026, 2:31 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Intraoperative Methadone for Postoperative Pain Control After Thoracic Surgery

NCT04525898
View directory record Official record
Conditions
Postoperative Pain
Interventions
Methadone
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 4 Interventional Results available

Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)

NCT03723447
View directory record Official record
Conditions
Pain, Postoperative, Crohn Disease, Inflammatory Bowel Diseases, Colorectal Cancer, Gastrointestinal Cancer, Gastrointestinal Disease, Digestive System Disease, Pain, Pain, Neuropathic, Intestinal Disease
Interventions
Liposomal bupivacaine, Bupivacaine/epinephrine/dexamethasone
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 4 Interventional Results available

Dexamethasone for Post Cesarean Delivery Analgesia

NCT01868633
View directory record Official record
Conditions
Postoperative Pain
Interventions
Dexamethasone, Placebo
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 18, 2017 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 3 Interventional Results available

A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement

NCT02132312
View directory record Official record
Conditions
Unilateral Cataract Extraction, Congenital Cataract
Interventions
OMS302, Phenylephrine HCl
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
1 Day to 47 Months
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
11
States / cities
Los Angeles, California • Atlanta, Georgia • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Jun 26, 2026, 2:31 PM EDT
Terminated Not applicable Interventional

Device for Monitoring Pain During Intraoperative, Pre/Post Surgical Periods: Comparison With Standard of Care Monitoring

NCT02630134
View directory record Official record
Conditions
Pain Measurement, Assessment, Pain
Interventions
These patients receive the Baeta device and take it home
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2017 · Synced Jun 26, 2026, 2:31 PM EDT
Recruiting Not applicable Interventional

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

NCT05991453
View directory record Official record
Conditions
Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity
Interventions
Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
13,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
20
States / cities
Little Rock, Arkansas • San Francisco, California • Stanford, California + 15 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery

NCT02509312
View directory record Official record
Conditions
Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity, Coagulation Defect; Postpartum, Postoperative Pain, Ketorolac Adverse Reaction, Blood Loss, Postoperative
Interventions
Ketorolac, Placebo
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Jun 26, 2026, 2:31 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Intraoperative Exercises & Musculoskeletal Pain in Gynecologic Surgeons

NCT05761288
View directory record Official record
Conditions
Work-related Injury, Physical Injury
Interventions
Intraoperative microbreaks and exercises
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Intra-operative Uterosacral Ligament Bupivacaine Injection During Minimally Invasive Hysterectomy

NCT04157075
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use
Interventions
Bupivacaine
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Female only
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Baltimore, Maryland • Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Jun 26, 2026, 2:31 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty

NCT00620828
View directory record Official record
Conditions
Osteoarthritis
Interventions
Placebo saline injection, Ropivicaine 0.5%
Other · Drug
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2015 · Synced Jun 26, 2026, 2:31 PM EDT