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ClinicalTrials.gov public records Last synced Oct 8, 2026, 7:51 AM EDT

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Showing 25–48 of 891 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Knee Arthroplasty Clear all
Enrolling by invitation Phase 4 Interventional

How Many Dexamethasone Doses Should Be Given Perioperatively?

NCT06715709
View directory record Official record
Conditions
Arthropathy of Knee
Interventions
Dexamethasone IV, Dexamethasone IV+Oral, Dexamethasone IV+Oral 2 Day
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
339 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 8, 2026, 7:51 AM EDT
Recruiting Not applicable Interventional

A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery

NCT07356323
View directory record Official record
Conditions
Arthroplasty Replacement, Knee, Arthroplasty Total Hip Replacement
Interventions
3M™ Ioban™ CHG Chlorhexidine Gluconate Incise Drape (2% w/w CHG)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
22 Years and older
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Fishers, Indiana • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 8, 2026, 7:51 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)

NCT04082533
View directory record Official record
Conditions
Pain, Arthrofibrosis, Osteoarthritis, Knee
Interventions
Hydrocortisone, Dextrose 5% in water (D5W)
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 83 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 8, 2026, 7:51 AM EDT
Completed No phase listed Observational

Stated-Preferences in Knee Arthroplasty

NCT03058380
View directory record Official record
Conditions
Arthritis, Knee Osteoarthritis, Arthropathy of Knee
Interventions
Stated-Preferences Evaluation Instrument
Other
Lead sponsor
Duke University
Other
Eligibility
40 Years to 80 Years
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 8, 2026, 7:51 AM EDT
Not listed No phase listed Observational

Diaphragmatic Breathing Exercises in Total Knee Arthroplasty Patients

NCT04336579
View directory record Official record
Conditions
Anesthesia and Analgesia
Interventions
Diaphragmatic Breathing
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
50 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional

Evaluating the Effectiveness of 2 Surgical Skin Preparation Methods in Reducing Surgical Wound Drainage After Total Hip or Knee Replacement

NCT01097135
View directory record Official record
Conditions
Drainage
Interventions
Duraprep Surgical Solution
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 17, 2013 · Synced Oct 8, 2026, 7:51 AM EDT
Not listed No phase listed Observational

A Prospective Radiostereometric Analysis (RSA) and Clinical Evaluation of the Triathlon Tritanium Total Knee Replacement

NCT02373761
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Stryker Triathlon Tritanium primary knee
Device
Lead sponsor
Scott Sporer
Other
Eligibility
18 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2015
U.S. locations
1
States / cities
Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 27, 2015 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Preoperative Carbohydrate Rich Drinks on Immediate Postoperative Outcome in Total Knee Arthroplasty

NCT03380754
View directory record Official record
Conditions
Post Operative Nausea and Vomiting
Interventions
Nutricia preOp, Nestle Splash Lemon Flavor Water (Placebo)
Dietary Supplement · Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional Results available

Brain Stimulation and Meditation for Pain After Total Knee Arthroplasty

NCT05673720
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
active tDCS paired with active MBM, sham tDCS paired with sham MBM
Device
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional

Opioid Reduction Program for Total Knee Replacement Patients

NCT05414942
View directory record Official record
Conditions
Knee Injuries, Knee Injuries and Disorders, Opioid Use
Interventions
Opioid Reduction Program
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional

Effects of tDCS Combined With CBI on Postsurgical Pain

NCT04199780
View directory record Official record
Conditions
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty (Postoperative Pain)
Interventions
Transcranial Direct Current Stimulation, Cognitive-Behavioral (CB) intervention
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 90 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 8, 2026, 7:51 AM EDT
Recruiting Not applicable Interventional

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

NCT05658796
View directory record Official record
Conditions
Mood Disorders, Anxiety, Depressive Symptoms, Depression, Anxiety Disorders, Anxiety Depression
Interventions
-RxWell
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 100 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 8, 2026, 7:51 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Training Following Total Knee Arthroplasty

NCT02763488
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
DelfiPTS tourniquet system, Standard physical therapy
Device · Other
Lead sponsor
San Antonio Military Medical Center
Federal
Eligibility
50 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 16, 2016 · Synced Oct 8, 2026, 7:51 AM EDT
Terminated Not applicable Interventional

Medial Peel Release Technique TKA Randomized Clinical Trial

NCT05154058
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis, Knee
Interventions
Medial Subperiosteal Release with Sharp Dissection, Medial Subperiosteal Release with Electrocautery
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Phase 2 Interventional Results available

Abbreviated Protocol for Two-Stage Exchange

NCT04662632
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty, VT-X7 Treatment System with Vancomycin Hydrochloride
Combination Product · Drug · Procedure
Lead sponsor
Osteal Therapeutics, Inc.
Industry
Eligibility
22 Years to 84 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
17
States / cities
Phoenix, Arizona • Torrance, California • Washington D.C., District of Columbia + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional

Radiofrequency For Chronic Knee Pain Post-Arthroplasty

NCT02931435
View directory record Official record
Conditions
Chronic Knee Pain, Osteoarthritis, Knee
Interventions
Nerve Block with Radiofrequency Ablation, Nerve Block with Sham Radiofrequency Ablation
Procedure
Lead sponsor
Randall Brewer, MD, CPI
Other
Eligibility
50 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced Oct 8, 2026, 7:51 AM EDT
Terminated Not applicable Interventional Results available

Bone Wax Use for Hemostasis During Primary Unilateral Total Knee Arthroplasty

NCT04992052
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Bone wax
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Syosset, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional

The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty

NCT07219329
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Weighted Blanket
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 8, 2026, 7:51 AM EDT
Not listed Phase 1 Interventional

Electrical Stimulation After Total Knee Arthroplasty

NCT00224913
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
Neuromuscular electrical stimulation, Voluntary exercise
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
45 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Oct 12, 2005 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preoperative Cognitive Therapy for Improving Health Outcomes After TKA in High-risk Catastrophizing Subjects

NCT01772329
View directory record Official record
Conditions
Catastrophization
Interventions
Cognitive Therapy, Routine Care
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Oct 8, 2026, 7:51 AM EDT
Completed No phase listed Observational

Prospective, Multiconfiguration Study to Assess Functional Performance of Primary Total Knee Arthroplasty System

NCT01746524
View directory record Official record
Conditions
Osteoarthritis
Interventions
ATTUNE Primary Total Knee Arthroplasty
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
1,138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
9
States / cities
Orange, California • San Diego, California • Fort Collins, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Phase 4 Interventional

Anatomic Reconstruction of the Patellofemoral Joint

NCT01375231
View directory record Official record
Conditions
Knee Replacement Surgery
Interventions
Measured Resection of patellofemoral joint, Measured resection of patella
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 30, 2014 · Synced Oct 8, 2026, 7:51 AM EDT
Terminated Not applicable Interventional Results available

Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA

NCT04712019
View directory record Official record
Conditions
Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases, Musculoskeletal Diseases, Edema Leg, Joint Pain, Arthritis Knee
Interventions
Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
6
States / cities
Annapolis, Maryland • Baltimore, Maryland • Columbia, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 8, 2026, 7:51 AM EDT
Completed Not applicable Interventional Results available

Zimmer POLAR - Total Knee Arthroplasty (TKA)

NCT01859130
View directory record Official record
Conditions
Osteoarthritis, RheumatoId Arthritis, Traumatic Arthritis, Polyarthritis
Interventions
Zimmer Persona Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 75 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
4
States / cities
Naperville, Illinois • Egg Harbor, New Jersey • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2023 · Synced Oct 8, 2026, 7:51 AM EDT