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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Knee Osteoarthritis (Knee OA) Clear all
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?

NCT06865170
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee, Fear of Needles
Interventions
25 gauge needle, 22 gauge needle, +/- Ethyl Chloride Topical Aerosol Anesthetic
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
40 Years to 89 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jun 10, 2026, 7:27 PM EDT
Recruiting Phase 4 Interventional

Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department

NCT06603662
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis (OA) of the Hip
Interventions
Prednisone, Dexamethasone, Placebo
Drug
Lead sponsor
WellSpan Health
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Non-Inferiority Study Comparing 3 Weekly Injections of SUPARTZ® vs 3 Weekly Injections of Euflexxa® for Knee OA

NCT02110238
View directory record Official record
Conditions
Osteoarthritis
Interventions
Supartz, Euflexxa
Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
40 Years to 80 Years
Enrollment
421 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 3 Interventional

Open Label Safety and Tolerability Study of COV155 in Subjects With Osteoarthritis (OA) or Chronic Low Back Pain (CLBP)

NCT01722864
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Low Back Pain
Interventions
COV155
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
34
States / cities
Anaheim, California • Lomita, California • Santa Ana, California + 24 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2016 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function

NCT00710840
View directory record Official record
Conditions
Osteoarthritis
Interventions
Minimally Invasive Total Knee Arthroplasty [TKA Min], Total Knee Arthroplasty (TKA) Traditional
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Boulder, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Home-based NMES Therapy for Knee Osteoarthritis Pain

NCT04128618
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
CyMedica e-vive NMES
Device
Lead sponsor
CyMedica Orthopedics, Inc
Industry
Eligibility
21 Years to 85 Years
Enrollment
159 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 24, 2020 · Synced Jun 10, 2026, 7:27 PM EDT
Completed No phase listed Observational

A Prospective Observational Study to Evaluate Long-term Changes in Cartilage Morphology in Subjects Who Previously Received TPX-100 or Placebo in Study TPX-100-1 for Patellar Osteoarthritis Involving Both Knees

NCT03125499
View directory record Official record
Conditions
Mild to Moderate Knee OA
Interventions
Previous treated with TPX-100
Other
Lead sponsor
OrthoTrophix, Inc
Industry
Eligibility
25 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Covina, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Jun 10, 2026, 7:27 PM EDT
Terminated Phase 2 Interventional

A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain

NCT00418782
View directory record Official record
Conditions
Osteoarthritis
Interventions
naproxen, CE-224535, placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
46
States / cities
Anniston, Alabama • Bayou La Batre, Alabama • Birmingham, Alabama + 39 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 3 Interventional

Doxycycline and OA Progression

NCT00000403
View directory record Official record
Conditions
Osteoarthritis
Interventions
Doxycycline
Drug
Lead sponsor
Indiana University
Other
Eligibility
45 Years to 64 Years · Female only
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2001
U.S. locations
6
States / cities
Birmingham, Alabama • Tucson, Arizona • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2013 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain

NCT05050448
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, 1% Diclofenac Topical Gel
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
3
States / cities
Stamford, Connecticut • Trumbull, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients

NCT03980964
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
Interventions
Active NMES
Device
Lead sponsor
CyMedica Orthopedics, Inc
Industry
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of RHH646 for Knee Osteoarthritis

NCT05816395
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
RHH646, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
35 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Lincoln, California • Winter Park, Florida • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 2 Interventional Results available

A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis

NCT03277066
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Diclofenac Sodium Active Topical Patch 1, Diclofenac Sodium Active Topical Patch 2, Placebo patch
Drug
Lead sponsor
Noven Pharmaceuticals, Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Jersey City, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 22, 2021 · Synced Jun 10, 2026, 7:27 PM EDT
Terminated Phase 2 Interventional Results available

A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain

NCT05838742
View directory record Official record
Conditions
Pain, Osteoarthritis, Knee
Interventions
GSK3858279, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
40 Years to 80 Years
Enrollment
314 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
15
States / cities
Cerritos, California • Huntington Beach, California • Santa Clara, California + 11 more
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Study of Pain Catastrophizing

NCT03836586
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cognitive-Behavioral Intervention, Pain Education
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
45 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 2 Interventional

Dose Finding Study of Bone Morphogenetic Protein 7 (BMP-7) in Subjects With Osteoarthritis (OA) of the Knee

NCT01111045
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Bone morphogenetic protein 7, Placebo
Drug
Lead sponsor
Stryker Biotech
Industry
Eligibility
40 Years and older
Enrollment
355 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
25
States / cities
Glendale, Arizona • Tucson, Arizona • Palo Alto, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2012 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Not applicable Interventional

Validation of a Low-cost Platelet-Rich Plasma (PRP)

NCT06184048
View directory record Official record
Conditions
Platelet-Rich Plasma (PRP), Knee Osteoarthritis (OA)
Interventions
Intra-Articular knee injection of LC-PRP
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Not applicable Interventional

Comparing Femoral Nerve Catheters to Single Shot Femoral Nerve Blocks for Total Knee Replacement Surgery

NCT02106481
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Femoral Nerve Catheters, Single Shot Femoral Nerve Blocks
Drug
Lead sponsor
Eastern Maine Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Bangor, Maine
Source: ClinicalTrials.gov public record
Updated Aug 2, 2016 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Not applicable Interventional

Can Computer-based Telephone Counseling Improve Long-term Adherence to Strength Training in Elders With Knee OA?

NCT01394874
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
TLC
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
55 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee

NCT03529942
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
FX006 32 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
9
States / cities
El Cajon, California • La Mesa, California • Pomona, California + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 2Phase 3 Interventional

A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)

NCT00536302
View directory record Official record
Conditions
Knee Osteoarthritis (OA)
Interventions
Collagen Hydrolysate, Placebo
Dietary Supplement
Lead sponsor
GELITA
Industry
Eligibility
49 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 5, 2009 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Not applicable Interventional

Yoga Versus Exercises for Managing OA

NCT02525341
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Hatha yoga, Aerobic and strengthening exercises, General education
Other
Lead sponsor
University of Minnesota
Other
Eligibility
60 Years to 100 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2019 · Synced Jun 10, 2026, 7:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Bracing on Knee Osteoarthritis (OA)

NCT01886144
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Knee OA Brace
Device
Lead sponsor
Stony Brook University
Other
Eligibility
35 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2014 · Synced Jun 10, 2026, 7:27 PM EDT
Completed Phase 3 Interventional

Study of Efficacy, Safety of Fulranumab Monotherapy for OA of Hip or Knee, PAI3003

NCT02289716
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Placebo, Fulranumab 1 mg, Fulranumab 3 mg
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 99 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
7
States / cities
El Cajon, California • Sherman Oaks, California • Miami, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Jun 10, 2026, 7:27 PM EDT