Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 9, 2026, 4:11 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 145 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lumbar Degenerative Disc Disease Clear all

Conditions: Degenerative Disc Disease
Interventions: IDCT (rebonuputemcel), Sham (No Treatment); Biological · Other
Lead sponsor: DiscGenics, Inc.; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 31
States / cities: Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 28 more

Conditions: Degenerative Disc Disease, Spondylolisthesis
Interventions: Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft; Device · Other
Lead sponsor: BioSurface Engineering Technologies, Inc; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 6
States / cities: Durango, Colorado • Washington D.C., District of Columbia • Kansas City, Kansas + 3 more

Conditions: Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions: Solum IV, Bone Marrow Concentrate with general fluid concentrate (GFC) in Transforaminal Lumbar Interbody Fusion; Combination Product
Lead sponsor: Seton Healthcare Family; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Lumbar Disc Disease
Interventions: Autologous bone marrow aspirate injected intradiscal after microdiscectomy, Discectomy only; Procedure
Lead sponsor: New York Presbyterian Hospital; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal, Intervertebral Disc Injury
Interventions: NSSD, Sham NSSD; Device
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years to 65 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Stanford, California • Tampa, Florida

Conditions: Intervertebral Disk Degeneration
Interventions: Hyperlordotic Positioning; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Degenerative Disc Disease, DDD, Degenerative Disc Disease Lumbar, Degenerative Disc Disease, Lumbar, Lumbar Disc Herniation, Disc Herniation, Lumbar, Bone Marrow Aspirate Concentrate, Intervertebral Disc Displacement, Low Back Pain, Chronic Low Back Pain (CLBP), CLBP - Chronic Low Back Pain
Interventions: Bone Marrow Aspirate Concentrate (BMAC); Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Manhattan, New York

Conditions: Lumbar Degenerative Disc Disease
Interventions: PureGen Osteoprogenitor Cell Allograft, Autograft bone; Biological · Procedure
Lead sponsor: Alphatec Spine, Inc.; Industry
Eligibility: 50 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Beverly Hills, California

Conditions: Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease (DDD)
Interventions: Not listed
Lead sponsor: Baxano Surgical, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 3
States / cities: Fullerton, California • Waterford, Michigan • Cleveland, Ohio

Conditions: Degenerative Disc Disease, Back Pain
Interventions: biologic, Osteocel Plus; Biological
Lead sponsor: NuVasive; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 13
States / cities: La Jolla, California • Hollywood, Florida • Miami Beach, Florida + 10 more

Conditions: Degenerative Disc Disease, Disc Degeneration, Lumbar Discogenic Pain
Interventions: VIA Disc NP, Sham; Other
Lead sponsor: VIVEX Biologics, Inc.; Industry
Eligibility: 22 Years to 85 Years
Enrollment: 325 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 19
States / cities: Napa, California • Santa Monica, California • Thornton, Colorado + 16 more

Conditions: Degenerative Disc Disease
Interventions: Active Allograft, Placebo; Other
Lead sponsor: VIVEX Biologics, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 218 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 13
States / cities: Santa Monica, California • Walnut Creek, California • Tampa, Florida + 10 more

Conditions: Degenerative Disc Disease, Spondylolisthesis, Retrolisthesis
Interventions: Surgery with the Keos Lumbar Interbody Fusion Device; Device
Lead sponsor: Invibio Ltd; Industry
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Lancaster, Pennsylvania

Conditions: Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions: Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion; Biological · Procedure
Lead sponsor: Induce Biologics USA Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Jasper, Alabama

Conditions: Intervertebral Disc Disease, Intervertebral Disc Degeneration, Spondylosis, Spondylolisthesis, Spinal Stenosis
Interventions: NuCel with Autograft; Other
Lead sponsor: NuTech Medical, Inc; Industry
Eligibility: 21 Years and older
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Lumbar Spondylolisthesis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Lumbar Radiculopathy, Lumbar Spinal Stenosis, Lumbar Disc Disease
Interventions: ViviGen® Cellular Bone Matrix with DePuy Synthes Spinal Pedicle screw system, Local Bone Autologous Bone Graft with DePuy Synthes Spinal pedicle screw system; Combination Product
Lead sponsor: Corewell Health East; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Degenerative Lumbar Spondylolisthesis
Interventions: Not listed
Lead sponsor: Olympus Biotech Corporation; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 19
States / cities: Santa Monica, California • Stanford, California • Denver, Colorado + 16 more

Conditions: Lumbar Degenerative Disc Disease
Interventions: SIFS graft containment device; Device
Lead sponsor: Spineology, Inc; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 10
States / cities: DeLand, Florida • Shreveport, Louisiana • Thibodaux, Louisiana + 7 more

Conditions: Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease
Interventions: Not listed
Lead sponsor: Baxano Surgical, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 11
States / cities: Fullerton, California • Los Angeles, California • Carmel, Indiana + 8 more

Conditions: Degenerative Disc Disease
Interventions: Intradiscal rhGDF-5; Drug
Lead sponsor: DePuy Spine; Industry
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 8
States / cities: Santa Monica, California • Durango, Colorado • Marietta, Georgia + 5 more

Conditions: Degeneration of Lumbar Intervertebral Disc
Interventions: Structural Allograft Spacer, OptiMesh 1500S; Device
Lead sponsor: Spineology, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2013
U.S. locations: 11
States / cities: Los Angeles, California • Coeur d'Alene, Idaho • Aurora, Illinois + 8 more

Conditions: Spinal Disease, Degenerative Disc Disease
Interventions: OssiMend™ Bioactive Moldable; Device
Lead sponsor: Collagen Matrix; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 4
States / cities: Encinitas, California • Hartford, Connecticut • Somerset, New Jersey + 1 more

Conditions: Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
Interventions: Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic, Muscle relaxant during maintenance anesthesia, Pain control with fentanyl, Bispectral Index (BIS) monitoring for depth of anesthesia, Spinal Anesthesia, Midazolam administered during spinal anesthesia, Cerebrospinal fluid collection, Administration of intrathecal morphine; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 65 Years and older
Enrollment: 218 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions: nanOss Bioactive - posterolateral gutter; Device
Lead sponsor: Pioneer Surgical Technology, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 3
States / cities: La Jolla, California • San Francisco, California • Columbia, Missouri

Search by objective public record fields.

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

Efficacy of Using Solum IV and BMC With GFC in TLIF

Injection of Autologous Bone Marrow Aspirate in Patients With Degenerative Disc Disease.

Non-surgical Spinal Decompression Therapy and Outcomes

Patient Positioning in Lumbar Fusion Surgery and Its Impact on Spinal Sagittal Balance and Surgeon Satisfaction

Biologic Injection For Adults With Lumbar Disc Herniation

Radiographic Analysis Using PureGen Versus Autologous Bone in Posterolateral Fusion (PLF)

Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures

Osteocel® Plus in eXtreme Lateral Interbody Fusion (XLIF®)

Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced.

Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion

Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine

Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease

Study of OP-1 Putty in Uninstrumented Posterolateral Fusions

Spineology Clinical Outcomes Trial: An IDE Investigation

RAMP Study: A Study Comparing Two Lumbar Fusion Procedures

Intradiscal rhGDF-5 Phase I/II Clinical Trial

OptiMesh® for Lumbar Interbody Fusion Trial (OLIF)

OssiMend BA in Posterolateral Instrumented Lumbar Fusion

Shaping Anesthetic Techniques to Reduce Post-operative Delirium

Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine