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ClinicalTrials.gov public records Last synced Oct 5, 2026, 2:29 PM EDT

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Showing 73–96 of 147 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lumbar Disc Degeneration Clear all
Completed No phase listed Observational

A Study Comparing Fusion Rates of Two Lumbar Fusion Procedures

NCT01972256
View directory record Official record
Conditions
Pseudoarthrosis, Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease (DDD)
Interventions
Not listed
Lead sponsor
Baxano Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
5
States / cities
Tampa, Florida • Indianapolis, Indiana • Baton Rouge, Louisiana + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2014 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease

NCT00316121
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
HEALOS and Leopard Cage, Leopard Cage and Autograft
Device
Lead sponsor
Advanced Technologies and Regenerative Medicine, LLC (ATRM)
Other
Eligibility
18 Years to 70 Years
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
17
States / cities
Little Rock, Arkansas • Beverly Hills, California • Brandon, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2011 · Synced Oct 5, 2026, 2:29 PM EDT
Active, not recruiting Phase 3 Interventional

Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine

NCT05516992
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
SB-01 For Injection, Sham Needle
Drug
Lead sponsor
Spine BioPharma, Inc
Industry
Eligibility
18 Years and older
Enrollment
417 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
30
States / cities
Birmingham, Alabama • Phoenix, Arizona • Napa, California + 24 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Oct 5, 2026, 2:29 PM EDT
Terminated Not applicable Interventional

Effectiveness of Lumbar Fusion When NanOss Bioactive Is Used With Posterolateral Gutter Fusions

NCT01452516
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions
nanOss Bioactive Bone void filler, Interbody FCage
Device
Lead sponsor
Pioneer Surgical Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
7
States / cities
Beverly Hills, California • La Jolla, California • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2016 · Synced Oct 5, 2026, 2:29 PM EDT
Completed No phase listed Observational

Multimodality Neuromonitoring in XLIF

NCT01499680
View directory record Official record
Conditions
Degeneration of Lumbar Intervertebral Disc
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
18
States / cities
La Jolla, California • Orange, California • Durango, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery

NCT03442374
View directory record Official record
Conditions
Disc Degeneration, Low Back Pain
Interventions
Exercise
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 85 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Phase 2 Interventional

Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain

NCT01290367
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Single Dose MPCs Injection, Single injection of saline solution, Single injection of hyaluronic acid
Biological · Procedure
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
13
States / cities
Scottsdale, Arizona • Sacramento, California • Santa Monica, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2020 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Phase 1 Interventional

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration

NCT03347708
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
IDCT, Saline Solution, Sodium Hyaluronate
Biological · Drug
Lead sponsor
DiscGenics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
14
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Phase 3 Interventional

Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.

NCT00215319
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Lumbar I/F with cage and pedicle screws
Device
Lead sponsor
DePuy Spine
Industry
Eligibility
18 Years to 79 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2006
U.S. locations
2
States / cities
Dothan, Alabama • Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 23, 2014 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Phase 3 Interventional

rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study

NCT00707265
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
rhBMP-2/CRM/CD HORIZON® Spinal System, Autograft/CD HORIZON® Spinal System
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
463 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2010
U.S. locations
28
States / cities
Phoenix, Arizona • Orange, California • Santa Monica, California + 25 more
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Oct 5, 2026, 2:29 PM EDT
Enrolling by invitation No phase listed Observational

Lumbar Interbody Implant Study

NCT04418830
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis, Sagittal Deformity
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
1,050 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
16
States / cities
La Jolla, California • Los Alamitos, California • Merced, California + 13 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 5, 2026, 2:29 PM EDT
Withdrawn Phase 3 Interventional

Peri-Incisional Drug Injection in Lumbar Spine Surgery

NCT03513445
View directory record Official record
Conditions
Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
Interventions
Morphine, Epinephrine, naropin
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 19, 2022 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Phase 1 Interventional

AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain

NCT03263611
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Placebo, AMG0103
Drug
Lead sponsor
AnGes, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
6
States / cities
Los Angeles, California • San Diego, California • St. Petersburg, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 5, 2026, 2:29 PM EDT
Not listed No phase listed Observational

Injection of Autologous Bone Marrow Aspirate in Patients With Degenerative Disc Disease.

NCT05146583
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
Autologous bone marrow aspirate injected intradiscal after microdiscectomy, Discectomy only
Procedure
Lead sponsor
New York Presbyterian Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 21, 2021 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

TRIUMPH Lumbar Artificial Disc IDE: A Pilot Study

NCT01198470
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
TRIUMPH® Lumbar Artificial Disc
Device
Lead sponsor
Globus Medical Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Savannah, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Phase 1Phase 2 Interventional

Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF)

NCT00549913
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis
Interventions
NeoFuse, posterolateral spinal fusion with instrumentation
Biological · Procedure
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Intradiscal rhGDF-5 Phase I/II Clinical Trial

NCT00813813
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Intradiscal rhGDF-5
Drug
Lead sponsor
DePuy Spine
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
8
States / cities
Santa Monica, California • Durango, Colorado • Marietta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2016 · Synced Oct 5, 2026, 2:29 PM EDT
Withdrawn Not applicable Interventional

Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF)

NCT01016314
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Aspen Spinous Process System, Pedicle Screw Fixation
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
5
States / cities
Pomona, California • Sacramento, California • Kansas City, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2019 · Synced Oct 5, 2026, 2:29 PM EDT
Completed No phase listed Observational

Fibergraft Interbody Fusion Retrospective

NCT03898232
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Degeneration, Spinal Stenosis
Interventions
Computed Tomography (CT) Scan of the Lumbar Spine
Radiation
Lead sponsor
Bone and Joint Clinic of Baton Rouge
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 29, 2021 · Synced Oct 5, 2026, 2:29 PM EDT
Completed No phase listed Observational

Osteocel® Plus in Anterior Lumbar Interbody Fusion (ALIF)

NCT00948831
View directory record Official record
Conditions
Degenerative Disc Disease, Lumbar
Interventions
Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
7
States / cities
San Francisco, California • Indianapolis, Indiana • Kokomo, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 5, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

Study of an Expandable Interbody Device for the Lumbar Spine

NCT02075554
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
CALIBER
Device
Lead sponsor
Globus Medical Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
2
States / cities
Miami Beach, Florida • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Oct 5, 2026, 2:29 PM EDT
Terminated No phase listed Observational

The Effectiveness of Anti-Gravity Treadmill Training

NCT01689922
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
AlterG
Other
Lead sponsor
Justin Parker Neurological Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 1, 2017 · Synced Oct 5, 2026, 2:29 PM EDT
Completed No phase listed Observational

A Prospective Non-concurrent Controlled Evaluation of Open and MAS® PLIF

NCT01640977
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
Open PLIF (posterior lumbar interbody fusion), MAS PLIF
Procedure
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
4
States / cities
Greensboro, North Carolina • York, Pennsylvania • Temple, Texas
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 5, 2026, 2:29 PM EDT
Completed No phase listed Observational

Advanced XLIF Monitoring Pilot Study

NCT02192112
View directory record Official record
Conditions
Degenerative Lumbar Disc Disease
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Durango, Colorado • Marrietta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 5, 2026, 2:29 PM EDT