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ClinicalTrials.gov public records Last synced Oct 19, 2026, 9:33 AM EDT

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Showing 1129–1152 of 1,368 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mental Health Impairment Clear all
Recruiting No phase listed Observational

Investigating Dynamic Interactions in Distributed Cognitive Control Networks

NCT05927974
View directory record Official record
Conditions
Cognitive Impairment, Dementia, ADD, Depression
Interventions
Passive testing, Active testing
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 19, 2026, 9:33 AM EDT
Completed Phase 2 Interventional

SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days)

NCT00438568
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Regular Insulin, Placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
55 Years and older
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 14, 2012 · Synced Oct 19, 2026, 9:33 AM EDT
Completed Phase 2 Interventional Results available

Effects of Atomoxetine in Mild Cognitive Impairment

NCT01522404
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Atomoxetine, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
50 Years to 90 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Oct 19, 2026, 9:33 AM EDT
Completed Not applicable Interventional

A Study of Decreased Mental Function Associated With HIV

NCT00027040
View directory record Official record
Conditions
Cognitive Disorders, HIV Infections
Interventions
Selegiline hydrochloride
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2005
U.S. locations
12
States / cities
Los Angeles, California • San Diego, California • Stanford, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2015 · Synced Oct 19, 2026, 9:33 AM EDT
Completed No phase listed Observational Results available

SAGE for the Early Detection of Cognitive Impairment at Primary Care Provider Visits

NCT04063371
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Self-Administered Gerocognitive Examination (SAGE) or Electronic Self-Administered Gerocognitive Examination (eSAGE), Informant Conversation
Other
Lead sponsor
Ohio State University
Other
Eligibility
65 Years to 89 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 14, 2024 · Synced Oct 19, 2026, 9:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Improved Diagnosis of Alzheimer's Disease Using the Synchronous Neural Interaction™ Test

NCT00666445
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Not listed
Lead sponsor
Orasi Medical, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
3
States / cities
Minneapolis, Minnesota • Plymouth, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 13, 2010 · Synced Oct 19, 2026, 9:33 AM EDT
Completed No phase listed Observational

Brain Imaging, Nutrition, and Cognition in Breast Cancer Survivors

NCT05122000
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
45 Years to 75 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Oct 19, 2026, 9:33 AM EDT
Enrolling by invitation Not applicable Interventional

Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015)

NCT06245031
View directory record Official record
Conditions
Alzheimer Disease, Cognitive Impairment, Mild Cognitive Impairment, Dementia, Mild, Dementia Moderate, Dementia Alzheimers, Dementia of Alzheimer Type, AD
Interventions
Sensory Stimulation System (GS120) - Active
Device
Lead sponsor
Cognito Therapeutics, Inc.
Industry
Eligibility
50 Years to 92 Years
Enrollment
402 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
53
States / cities
Phoenix, Arizona • Sun City, Arizona • Anaheim, California + 48 more
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Oct 19, 2026, 9:33 AM EDT
Not listed Not applicable Interventional

FE-SaLiR: Function Improvement Exercise

NCT04284137
View directory record Official record
Conditions
Disability Physical, Cognitive Impairment
Interventions
Modified FE-SaLiR, Unmodified Chinese Medicine Exercise, Active Control
Behavioral
Lead sponsor
The University of Texas at San Antonio
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Oct 19, 2026, 9:33 AM EDT
Active, not recruiting Not applicable Interventional

Neurofeedback to Improve Working Memory in Mild Cognitive Impairment

NCT04566900
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Neurofeedback, Placebo
Behavioral · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
50 Years to 85 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 19, 2026, 9:33 AM EDT
Completed Phase 1 Interventional

Home Care Medication Management Program for the Frail Elderly

NCT01321853
View directory record Official record
Conditions
Chronic Illness, Cognitive Impairment
Interventions
MD2 machine and nurse care coordination, Medplanner and Nurse Care Coordination
Other
Lead sponsor
Arizona State University
Other
Eligibility
60 Years and older
Enrollment
414 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 6, 2012 · Synced Oct 19, 2026, 9:33 AM EDT
Recruiting No phase listed Observational

Imaging the Pathogenesis of Cerebral Small Vessel Disease

NCT05703386
View directory record Official record
Conditions
Ischemic Stroke, Hypertension, Hyperlipidemias, Diabetes
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Timeline
2022 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 19, 2026, 9:33 AM EDT
Active, not recruiting Not applicable Interventional

Remote Game-based Exercise Program for Cognitive and Motor Function Improvement

NCT05235113
View directory record Official record
Conditions
Mild Cognitive Impairment, Dementia, Cognitive Impairment, Memory Loss
Interventions
Tele-Exergame Platform, No Tele-Exergame Platform
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
55 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Los Angeles, California • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 19, 2026, 9:33 AM EDT
Recruiting Not applicable Interventional

Time Restricted Eating in Alzheimer's Disease

NCT06429124
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
Dietary Intervention
Behavioral
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
55 Years to 89 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 19, 2026, 9:33 AM EDT
Completed Phase 3 Interventional

Investigation Into Delay to Diagnosis of Alzheimer's Disease With Exelon (InDDEx)

NCT00000174
View directory record Official record
Conditions
Alzheimer Disease, Cognition Disorders
Interventions
Rivastigmine
Drug
Lead sponsor
Novartis
Industry
Eligibility
55 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
15
States / cities
Peoria, Arizona • Orange, California • Denver, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 19, 2026, 9:33 AM EDT
Completed No phase listed Observational

The Role Of Cognitive Impairment In The Use Of The Diskus Inhaler

NCT00891059
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Not listed
Lead sponsor
Synergy Health Solutions
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
2
States / cities
Brooksville, Florida • Centerville, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 23, 2010 · Synced Oct 19, 2026, 9:33 AM EDT
Completed Phase 1Phase 2 Interventional

SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD)

NCT04381468
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Pepinemab, Placebo
Drug
Lead sponsor
Vaccinex Inc.
Industry
Eligibility
55 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
14
States / cities
San Diego, California • Washington D.C., District of Columbia • Delray Beach, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Oct 19, 2026, 9:33 AM EDT
Terminated Phase 1 Interventional

A Proof of Concept Study of the Prevention of Mild Cognitive Impairment and Eventual Alzheimer's Disease Using F18 Flutemetamol

NCT03274817
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Escitalopram Pill, Venlafaxine Pill, Placebo Oral Tablet
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
60 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2020 · Synced Oct 19, 2026, 9:33 AM EDT
Recruiting Phase 2 Interventional

Repurposing Siponimod for Alzheimer's Disease

NCT06639282
View directory record Official record
Conditions
Alzheimer Disease, Mild Alzheimer Disease, MCI With Increased Risk for Alzheimer Disease, Cognitive Impairment, Mild
Interventions
Siponimod, Placebo
Drug
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
50 Years to 85 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 19, 2026, 9:33 AM EDT
Completed Not applicable Interventional Results available

Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training

NCT03503669
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Memory Training, Kundalini yoga and meditation
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years to 90 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Oct 19, 2026, 9:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM)

NCT02001441
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
University of California, Los Angeles
Other
Eligibility
60 Years to 89 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 2, 2018 · Synced Oct 19, 2026, 9:33 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

ADRC Clinical Cohort (Alzheimer's Disease)

NCT06703541
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Dementia
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
25 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 19, 2026, 9:33 AM EDT
Completed Not applicable Interventional

The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status

NCT00469482
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Critically Ill
Interventions
Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Oct 19, 2026, 9:33 AM EDT
Not yet recruiting Not applicable Interventional

Ketogenic Diet to Reduce Osteoarthritis Pain in MCI

NCT07417891
View directory record Official record
Conditions
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis, Mild Cognitive Impairment, MCI, Mild Cognitive Impairment (MCI), Dementia
Interventions
Well-formulated ketogenic diet
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
55 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Fairway, Kansas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 19, 2026, 9:33 AM EDT