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Showing 1–24 of 823 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mild Cognitive Impairment Clear all
Completed No phase listed Observational Accepts healthy volunteers

Alzheimer's Disease Neuroimaging Initiative Grand Opportunity

NCT01078636
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Not listed
Lead sponsor
Alzheimer's Disease Cooperative Study (ADCS)
Other
Eligibility
55 Years to 90 Years
Enrollment
342 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
50
States / cities
Birmingham, Alabama • Phoenix, Arizona • Sun City, Arizona + 39 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2014 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional Results available

Cognitive Rehab for Parkinson's

NCT03836963
View directory record Official record
Conditions
Parkinson's Disease, Mild Cognitive Impairment
Interventions
cognitive training, active control cognitive training, memory strategy training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 21, 2024 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Phase 4 Interventional Results available

Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care

NCT01993836
View directory record Official record
Conditions
Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
Interventions
Total intravenous anesthesia with propofol, General anesthesia with isoflurane
Drug
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional

Computer-based Cognitive Training for Individuals With Parkinson's Disease

NCT02225314
View directory record Official record
Conditions
Parkinson's Disease, Mild Cognitive Impairment
Interventions
Brain Fitness, InSight, Active Control
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 90 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2016 · Synced Jul 23, 2026, 11:40 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging

NCT03954899
View directory record Official record
Conditions
Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
Interventions
melatonin, placebo
Dietary Supplement · Other
Lead sponsor
Natalie Denburg
Other
Eligibility
56 Years to 85 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Minocycline in Patients With Alzheimer's Disease

NCT01463384
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Minocycline
Drug
Lead sponsor
Huntington Medical Research Institutes
Other
Eligibility
55 Years to 90 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2014 · Synced Jul 23, 2026, 11:40 PM EDT
Terminated Phase 2 Interventional Results available

A Study of Aducanumab in Participants With Mild Cognitive Impairment Due to Alzheimer's Disease or With Mild Alzheimer's Disease Dementia to Evaluate the Safety of Continued Dosing in Participants With Asymptomatic Amyloid-Related Imaging Abnormalities

NCT03639987
View directory record Official record
Conditions
Cognitive Dysfunction, Alzheimer's Disease
Interventions
Aducanumab, Placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
50 Years to 85 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
22
States / cities
Phoenix, Arizona • Tucson, Arizona • Fullerton, California + 18 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Jul 23, 2026, 11:40 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Biomarker Exploration in Aging, Cognition and Neurodegeneration

NCT03860857
View directory record Official record
Conditions
Alzheimer Disease, Cognitive Impairment, Cognitive Decline
Interventions
Amyloid PET scan, Tau PET scan using MK-6240, Neurocognitive testing, MRI
Radiation · Drug · Behavioral + 1 more
Lead sponsor
University of California, Irvine
Other
Eligibility
60 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional

Comparing Smartphone Technology and a Memory Strategy on Improving Prospective Memory in Alzheimer's Disease

NCT03384043
View directory record Official record
Conditions
Alzheimer Disease, Cognitive Impairment, Mild, Dementia, Mild
Interventions
Smartphone Personal Assistant, Implementation Intention
Behavioral
Lead sponsor
Baylor University
Other
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Temple, Texas
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Jul 23, 2026, 11:40 PM EDT
Recruiting Not applicable Interventional

Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment

NCT05858008
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Time-restricted eating
Behavioral
Lead sponsor
Julie Pendergast
Other
Eligibility
45 Years to 95 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 23, 2026, 11:40 PM EDT
Recruiting Not applicable Interventional

Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

NCT04558164
View directory record Official record
Conditions
Cognitive Dysfunction, Memory Disorders in Old Age
Interventions
Active Theta Burst Stimulation, Sham Theta Burst Stimulation
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
55 Years to 100 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional

Deep Brain Stimulation with LIFUP for Mild Cognitive Impairment and Mild Alzheimer's Disease

NCT03347084
View directory record Official record
Conditions
Brain Imaging, Mild Cognitive Impairment, Alzheimer Disease, Deep Brain Stimulation
Interventions
Excitation, Inhibition
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
55 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2024 · Synced Jul 23, 2026, 11:40 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

NCT07424365
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
Interventions
transcutaneous auricular vagus nerve stimulation, sham stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 23, 2026, 11:40 PM EDT
Active, not recruiting Phase 2 Interventional

A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

NCT06223360
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Low Dose Benfotiamine, High Dose Benfotiamine, Placebo
Drug
Lead sponsor
Alzheimer's Disease Cooperative Study (ADCS)
Other
Eligibility
50 Years to 89 Years
Enrollment
406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
47
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Sun City, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 23, 2026, 11:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Dementia Signal Development Study of Nautilus NeuroWave TM for the Detection of Dementia

NCT02333942
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Frontotemporal Lobar Degeneration, Memory Disorders
Interventions
Nautilus NeuroWaveTM System
Device
Lead sponsor
Jan Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 12, 2019 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional

Energy Metabolism and Cognitive Aging

NCT00777010
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Ketogenic diet, Healthy high carbohydrate diet
Other
Lead sponsor
University of Cincinnati
Other
Eligibility
50 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional

Auburn University Research on Olive Oil for Alzheimer's Disease (AU-ROOAD)

NCT03824197
View directory record Official record
Conditions
Alzheimer Disease, Cerebral Amyloid Angiopathy
Interventions
EVOO, OO
Other
Lead sponsor
Auburn University
Other
Eligibility
55 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced Jul 23, 2026, 11:40 PM EDT
Active, not recruiting Phase 2 Interventional

Rapamycin - Effects on Alzheimer's and Cognitive Health

NCT04629495
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Disease
Interventions
Rapamycin, Placebo
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
55 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional Results available

PRIMA Intervention for Adults With Mild Cognitive Impairment and Their Caregivers

NCT04515875
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Daily Engagement Meaningful Activity (DEMA), Information Support (IS)
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 100 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional

Cognitive and Aerobic Resilience for the Brain

NCT02390453
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Combined Cognitive and Physical, Cognitive, Physical, Active Control
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional Results available

Feasibility of the Mindfulness-Based Stress Reduction Intervention for Black Women Living With HIV Supplement

NCT04984681
View directory record Official record
Conditions
HIV Infections, Mild Cognitive Impairment
Interventions
Mindfulness, Usual Care
Behavioral · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Phase 2 Interventional Results available

Study of Intravenous Immunoglobulin in Amnestic Mild Cognitive Impairment

NCT01300728
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
NewGam 10% IVIG, Placebo
Drug · Other
Lead sponsor
Sutter Health
Other
Eligibility
50 Years to 84 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Jul 23, 2026, 11:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

MI-CBT Adherence Program for Lifestyle Interventions in Older Adults

NCT04817176
View directory record Official record
Conditions
Mild Cognitive Impairment, Adherence, Patient, Ketosis
Interventions
Motivational Interviewing-Cognitive Behavioral Therapy Ketogenic Nutrition Adherence Program, Ketogenic Nutrition Program
Behavioral · Other
Lead sponsor
Florida State University
Other
Eligibility
60 Years to 85 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Jul 23, 2026, 11:40 PM EDT
Enrolling by invitation Not applicable Interventional

Impact of Yoga on Cognitive Function

NCT06434168
View directory record Official record
Conditions
Heart Failure, Mild Cognitive Impairment
Interventions
Yoga intervention, Control condition
Behavioral
Lead sponsor
Auburn University
Other
Eligibility
55 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 23, 2026, 11:40 PM EDT