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ClinicalTrials.gov public records Last synced Jun 7, 2026, 7:49 AM EDT

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Showing 1–24 of 813 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mild Cognitive Impairment Clear all
Active, not recruiting Phase 2 Interventional

A Study to Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age

NCT05399888
View directory record Official record
Conditions
Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer's Disease Dementia
Interventions
BIIB080, BIIB080-matching placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
50 Years to 80 Years
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
36
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Sun City, Arizona + 30 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Phase 1 Interventional

Evaluation of E2609 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (Study: E2609-A001-101 Amendment 02)

NCT01600859
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
E2609, Placebo for E2609
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
50 Years to 85 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Glendale, California • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 29, 2016 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Not applicable Interventional

The Effects of Music Listening on Anxiety and Agitation in People With Mild and Moderate Cognitive Impairment

NCT05858541
View directory record Official record
Conditions
Anxiety, Agitated Depression
Interventions
Music Listening, Listening to Audiobooks
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
65 Years to 85 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Phase 2 Interventional

Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Open Label Extension (CT04 OLEP)

NCT01421056
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
CHF 5074 1x, CHF 5074 2x, CHF 5074 3x
Drug
Lead sponsor
Chiesi Farmaceutici S.p.A.
Industry
Eligibility
18 Years to 79 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
4
States / cities
Eatontown, New Jersey • Monroe Twp, New Jersey • Toms River, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2014 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Not applicable Interventional Results available

Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment

NCT04533204
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
mnemonic strategy training, spaced retrieval training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Placebo Controlled Study of Atomoxetine in the Treatment of Mild to Moderate Cognitive Difficulties in Menopausal Women

NCT00611533
View directory record Official record
Conditions
Menopause, Cognitive Disturbances
Interventions
atomoxetine, placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 60 Years · Female only
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jun 7, 2026, 7:49 AM EDT
Recruiting Not applicable Interventional

Race-Based Stress and Cognitive Training for MCI

NCT06330844
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Race Based Stress and Empowerment Focused Compensatory Cognitive Training for Mild Cognitive Impairment (RBSEF-CCT-MCI), Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT)
Behavioral
Lead sponsor
Rosalind Franklin University of Medicine and Science
Other
Eligibility
65 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Not applicable Interventional

Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)

NCT05217849
View directory record Official record
Conditions
Mild Cognitive Impairment, Subjective Memory Decline
Interventions
Tai Chi, Preventing Loss of Independence through Exercise (PLIE), Health and Wellness Education
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
55 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Recruiting Phase 3 Interventional

A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

NCT07169578
View directory record Official record
Conditions
Alzheimers Disease
Interventions
Trontinemab, Placebo
Drug · Other
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
50 Years to 90 Years
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
35
States / cities
Birmingham, Alabama • Sun City, Arizona • Irvine, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Terminated Not applicable Interventional Results available

mSIM: Mobile Simultaneous Aerobic Exercise and Memory Training Intervention for Amnestic Mild Cognitive Impairment

NCT04185298
View directory record Official record
Conditions
Amnestic Mild Cognitive Impairment
Interventions
mSIM intervention plus activity monitoring, Activity monitoring
Behavioral
Lead sponsor
Jennifer Bramen
Other
Eligibility
50 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Jun 7, 2026, 7:49 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)

NCT07180147
View directory record Official record
Conditions
Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome, Disability Physical, Hypertension, Metabolic Syndrome (MetS), Healthy Aging, Obesity &Amp; Overweight
Interventions
Not listed
Lead sponsor
Marymount University
Other
Eligibility
50 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2031
U.S. locations
1
States / cities
Arlington, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Terminated Early Phase 1 Interventional Results available

Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment

NCT03937908
View directory record Official record
Conditions
Cognitive Impairment, Elderly
Interventions
2g Centella asiatica water extract product, 4g Centella asiatica water extract product
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
65 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Not applicable Interventional

Cognitive Training in Mild Cognitive Impairment

NCT04899089
View directory record Official record
Conditions
Insomnia, Mild Cognitive Impairment
Interventions
Cognitive Training, Trivia Training
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
60 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 29, 2023 · Synced Jun 7, 2026, 7:49 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Tau PET in Imaging and Cognition: Healthy Adults From 55-90

NCT03372317
View directory record Official record
Conditions
Mild Cognitive Impairment, Aging
Interventions
18F-MK-6240
Drug
Lead sponsor
Yaakov Stern
Other
Eligibility
55 Years to 90 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Phase 4 Interventional Results available

Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly

NCT01951118
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Delirium, Dementia, Amnestic, Cognitive Disorders
Interventions
Donepezil
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
55 Years to 95 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Not applicable Interventional Results available

Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults

NCT03960476
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Long-Term Care Planning
Interventions
PlanYourLifespan.org
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
55 Years and older
Enrollment
293 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Music Improvisation Training on Cognitive Function in Older Adults

NCT06721390
View directory record Official record
Conditions
Aging, Cognitive Aging, Cognitive Impairment, Cognitive Training, Mild Cognitive Impairment, Cognitively Normal Older Adults
Interventions
Piano Improvisation, Music Listening
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years and older
Enrollment
238 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Phase 2 Interventional Results available

Valacyclovir for Mild Cognitive Impairment

NCT04710030
View directory record Official record
Conditions
Mild Cognitive Impairment, Herpes Simplex 1, Herpes Simplex 2
Interventions
Valacyclovir hydrochloride 500mg caplet, Placebo sugar pill caplet
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
50 Years to 95 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Not listed No phase listed Observational

Diagnosis of Alzheimer's Disease Using Event Related Potentials

NCT02957227
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
No intervention is part of this study but patients use an EEG device during observational data collection.
Device
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
50 Years to 100 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Jamaica Plain, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 9, 2022 · Synced Jun 7, 2026, 7:49 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Assessing Cognitive Decline at Home

NCT06704971
View directory record Official record
Conditions
Mild Cognitive Impairment, Mild Dementia, Dementia Alzheimers, Dementia, Memory Impairment, NPS
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
65 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jun 7, 2026, 7:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Brain Health Champion Study

NCT03772977
View directory record Official record
Conditions
Mild Cognitive Impairment, Dementia, Mild, Subjective Cognitive Decline, At Risk for Cognitive Decline
Interventions
Brain Health Champion
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
60 Years to 79 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Not applicable Interventional Results available

Smartphone App to Improve Physical Activity in Older Adults With MCI/Mild Dementia

NCT04950998
View directory record Official record
Conditions
Sedentary Lifestyle, Dementia, Mild, Mild Cognitive Impairment, Memory and Thinking Problems
Interventions
Moving Up - A
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
65 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Consumption of Potatoes, Avocados and Chickpeas and Cognitive Function in Older Adults

NCT01620567
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
avocado, potato or chickpea
Other
Lead sponsor
Tufts University
Other
Eligibility
50 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 18, 2019 · Synced Jun 7, 2026, 7:49 AM EDT
Completed Phase 2 Interventional Results available

CAndesartan vs LIsinopril Effects on the BRain

NCT01984164
View directory record Official record
Conditions
Hypertension, Mild Cognitive Impairment
Interventions
Candesartan, Lisinopril
Drug
Lead sponsor
Emory University
Other
Eligibility
55 Years and older
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Jun 7, 2026, 7:49 AM EDT