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ClinicalTrials.gov public records Last synced Oct 22, 2026, 8:05 PM EDT

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Showing 145–168 of 572 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Nerve Blocks Clear all
Withdrawn Not applicable Interventional

Trial Comparing Duration of Analgesia After Popliteal Fossa Sciatiac Nerve Block With Ropivacaine 0.5% When Combined With Placebo, Dexamethasone 4mg or Dexamethasone 8 mg

NCT01641419
View directory record Official record
Conditions
Pain, Sciatic Block
Interventions
Placebo, Dexamethasone 4 mg, Dexamethasone 8 mg
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

NCT05868330
View directory record Official record
Conditions
Post Operative Pain, Anesthesia, Nerve Block, Shoulder Osteoarthritis
Interventions
Interscalene Catheter, Exparel Single Shot Interscalene Block
Procedure
Lead sponsor
Melinda Seering
Other
Eligibility
18 Years to 90 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting Phase 1Phase 2 Interventional

MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas

NCT06712875
View directory record Official record
Conditions
Low Grade Glioma, High Grade Glioma
Interventions
Trametinib and Nivolumab, Dabrafenib, trametinib, nivolumab
Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
1 Year to 26 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Chicago, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 3 Interventional

A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain

NCT04504812
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Duloxetine, Intra-Articular Injection, Nerve Procedure with long acting blocks, Nerve Procedure with nerve ablation, Pain Coping Skills Training, Best Practices
Drug · Combination Product · Procedure + 2 more
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
1,937 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
24
States / cities
Sacramento, California • San Diego, California • Aurora, Colorado + 19 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

A Research Study of Greater Occipital Nerve Block as a Treatment for Acute Migraine Attacks

NCT03159000
View directory record Official record
Conditions
Migraine
Interventions
Saline, lidocaine/bupivacaine
Drug · Combination Product
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 26, 2021 · Synced Oct 22, 2026, 8:05 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Adductor Canal Mid-thigh and Adductor Canal Distal Thigh: Is Cutaneous Sensory Blockade Similar Among Block Techniques?

NCT02788019
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ropivacaine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 21, 2021 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 3 Interventional Results available

Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy

NCT05157841
View directory record Official record
Conditions
Bunionectomy, Hallux Valgus
Interventions
Bupivacaine liposome injectable suspension 266 mg, Bupivacaine HCl, Bupivacaine liposome injectable suspension 133 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
7
States / cities
North Little Rock, Arkansas • Pasadena, California • Dayton, Ohio + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ultrasound-guided Nerve Block Training Model and Evaluation Method

NCT06219005
View directory record Official record
Conditions
Nerve Blocks, Medical Education, Simulation, Crisis Resource Management, Medical Education in Emergency Ultrasound
Interventions
ultrasound education and simulation workshop
Behavioral
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 4 Interventional Results available

Trial Comparing the Onset and Duration of Ultrasound Guided Supraclavicular Nerve Blocks Using Ropivacaine Versus Ropivacaine-Chloroprocaine Mixture

NCT01719237
View directory record Official record
Conditions
Pain
Interventions
Ropivacine and Chloroprocaine mixture, Ropivacaine only
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Oct 22, 2026, 8:05 PM EDT
Terminated Phase 3 Interventional Results available

ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain

NCT03261193
View directory record Official record
Conditions
Pain, Postoperative
Interventions
ITM + Sham QLB, ITM + Bupivacaine QLB
Drug
Lead sponsor
Nicholas Schott
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting Early Phase 1 Interventional

Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?

NCT06016465
View directory record Official record
Conditions
Migraine
Interventions
Dexamethasone Oral, Placebo
Drug
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years to 85 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Not applicable Interventional Results available

Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration

NCT02658240
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ropivacaine, Epinephrine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting Phase 2 Interventional

Efficacy of Nerve Blocks for Episodic Migraine

NCT05734625
View directory record Official record
Conditions
Episodic Migraine
Interventions
Bupivacaine HCl 0.5% Injectable Solution, Methylprednisolone 40 MG Injection
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Early Phase 1 Interventional

PECS Block: Plasma Bupivacaine Level

NCT03059498
View directory record Official record
Conditions
Nerve Blocks
Interventions
Unilateral PECS I and II block, Bilateral PECS I and II block, Bupivacaine
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 15, 2021 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Not applicable Interventional

Prospective RCT Comparing Perioperative Pain

NCT03253198
View directory record Official record
Conditions
Arthroplasty Shoulder
Interventions
Saline, Bupivacaine liposome
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 22, 2018 · Synced Oct 22, 2026, 8:05 PM EDT
Terminated Phase 4 Interventional

Ultrasound-Guided Continuous Sciatic Nerve Blocks: Popliteal Versus Subgluteal Catheters

NCT01325012
View directory record Official record
Conditions
Foot Surgery
Interventions
Subgluteal Sciatic Nerve Block, Popliteal Sciatic Nerve Block
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2013 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Regional Blocks for Lateral Condyle Fractures

NCT03796572
View directory record Official record
Conditions
Fractures, Closed, Humeral Fractures, Pain
Interventions
Ropivacaine, Puncture Wound and Dressing
Drug · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
4 Years to 12 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Ultrasound Guided Adductor Canal Block Versus Femoral Nerve Block for Quadriceps Strength and Fall-risk

NCT01655277
View directory record Official record
Conditions
Quadriceps Muscle Weakness, Adductor Muscle Weakness, Fall Risk
Interventions
Ultrasound Guided Adductor Canal Block, Ultrasound Guided Femoral Nerve Block
Procedure
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 1, 2012 · Synced Oct 22, 2026, 8:05 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Effect of Ropivacaine During Popliteal Nerve Block in Foot and Ankle Surgery

NCT04872322
View directory record Official record
Conditions
Popliteal Nerve Block, Foot Surgery, Ankle Surgery
Interventions
Ropivacaine 0.5% Injectable Solution, Ropivacaine 0.25% Injectable Solution, Percocet Pill, Norco Pill, Foot/Ankle Surgery
Drug · Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced Oct 22, 2026, 8:05 PM EDT
Terminated Phase 2 Interventional Results available

Femoral Nerve Block for Femur Fracture Repair in Pediatrics

NCT01759407
View directory record Official record
Conditions
Traumatic Femur Fracture
Interventions
Ropivicaine, Epinephrine
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Up to 18 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Oct 22, 2026, 8:05 PM EDT
Completed No phase listed Observational

Study Comparing Ultrasound-guided FICNB Block to Systemic Analgesia in Treatment of Pediatric Femur Fracture

NCT05947292
View directory record Official record
Conditions
Femur Fracture
Interventions
Ultrasound-Guided Fascia Iliaca Compartment Nerve Block
Procedure
Lead sponsor
Zachary Binder
Other
Eligibility
4 Years to 17 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
9
States / cities
San Diego, California • San Francisco, California • Denver, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting Early Phase 1 Interventional

Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion

NCT05461092
View directory record Official record
Conditions
Delirium, Pain, Back, Spinal Fusion, Thoracolumbar Interfascial Plane Block
Interventions
Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine, Blood Test, 3D CAM Delirium Severity Scoring, Generalized Anxiety Disorder 7-item (GAD-7) scale, Numerical Rating Score (NRS), PROMIS-Pain Interference, Oswestry Disability Index (ODI), Saint Louis University Mental Status Examination (SLUMs), Delirium Rating Scale-Revised-98 (DRS), Telephone Interview for Cognitive Status - Modified (TICS-M), Opioid Equivalents measured by Morphine Milligram Equivalents (MME), Patient Health Questionnaire depression scale (PHQ-8), Pain Catastrophizing, Fear Avoidance Beliefs Questionnaire (FABQ), Opioid Side Effects and Likeability Questionnaire, Daily Pain Trajectory, Tampa Scale of Kinesiophobia, Quality of Recovery 15
Drug · Diagnostic Test · Other
Lead sponsor
University of Iowa
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Terminated Phase 3 Interventional Results available

Paravertebral Block (PVC) Versus Pectoral Nerve Block (PEC)

NCT03152929
View directory record Official record
Conditions
Breast Cancer
Interventions
Paravertebral Block, Pectoral Nerve Block
Drug
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years and older · Female only
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting No phase listed Observational

Median Versus Ulnar Nerve Quantitative Electromyography Neuromuscular Blockade Monitoring Comparison

NCT06553131
View directory record Official record
Conditions
Neuromuscular Blockade
Interventions
Neuromuscular Transmission Monitoring
Device
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Oct 22, 2026, 8:05 PM EDT