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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nuclear Sclerosis Clear all
Completed Not applicable Interventional

Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification Cataract Surgery

NCT02561104
View directory record Official record
Conditions
Incipient Cataract, Senile Nuclear Sclerosis
Interventions
Laser-assisted cataract surgery., Traditional manual phacoemulsification
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 99 Years
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 20, 2020 · Synced Jul 22, 2026, 11:54 AM EDT
Recruiting Not applicable Interventional

This Clinical Trial Compares Two Phacoemulsification Systems Used in a Bilateral Cataract Surgery Subjects in Order to Study CDE and Ultrasound Time During Cataract Removal

NCT07468877
View directory record Official record
Conditions
Nuclear Sclerosis of the Lens, Phacoemulsification Cataract Surgery, Cataract Bilateral
Interventions
Cataract extraction with phacoemulsification comparing two systems
Device
Lead sponsor
Nicole Fram M.D.
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 22, 2026, 11:54 AM EDT
Completed Not applicable Interventional

The Post-Vitrectomy Lenstatin™ Study

NCT02131194
View directory record Official record
Conditions
Cataract, Nuclear Progressive
Interventions
Lenstatin, Placebo
Dietary Supplement · Drug
Lead sponsor
Lenstatin LLC
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Wilmington, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Jul 22, 2026, 11:54 AM EDT
Completed Not applicable Interventional

The Comparison of Cataract Lasers Using the Optimedica Catalys Laser and the Alcon LenSx Laser.

NCT01878838
View directory record Official record
Conditions
Nuclear Sclerosis of the Lens, Posterior Subcapsular Cataract, Cortical Cataract
Interventions
Femtosecond Laser Assisted Cataract Surgery w/ Catalys Laser, Femtosecond Laser Assisted Cataract Surgery w/ LenSx Laser
Procedure
Lead sponsor
Steven H. Linn, OD
Other
Eligibility
22 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Jul 22, 2026, 11:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Need for the Pseudophakic Intraoperative Abberrometry in Toric IOL Implantation

NCT03819842
View directory record Official record
Conditions
Cataract, Nuclear Sclerosis, Cortical Cataract, Posterior Subcapsular Cataract, Astigmatism
Interventions
Pseudophakic Measurement
Diagnostic Test
Lead sponsor
Alterman, Modi, & Wolter Ophthalmic Physicians & Surgeons
Other
Eligibility
30 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Poughkeepsie, New York
Source: ClinicalTrials.gov public record
Updated Jan 19, 2022 · Synced Jul 22, 2026, 11:54 AM EDT
Completed Phase 1Phase 2 Interventional

The Safety and Efficacy Study of Ethylenediaminetetraacetic Acid (EDTA) Ophthalmic Solution in Patients With Loss of Contrast Sensitivity Due to Age-Related, Low-Grade Nuclear Cataract

NCT06365762
View directory record Official record
Conditions
Age Related Cataracts
Interventions
EDTA Ophthalmic Solution 2.6%, EDTA Ophthalmic Solution 1.3%, Saline Solution (Placebo)
Drug
Lead sponsor
Livionex Inc.
Industry
Eligibility
50 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
6
States / cities
San Francisco, California • Overland Park, Kansas • Lutherville, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Jul 22, 2026, 11:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Less Discomfort and Less Pharmacology. Cataract Surgery at Physiologic Intraocular Pressure (IOP)

NCT06325397
View directory record Official record
Conditions
Nuclear Cataract
Interventions
High Intraocular Pressure (IOP), Low Intraocular Pressure (IOP)
Other
Lead sponsor
Matthew Rauen
Other
Eligibility
Not listed
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
West Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Jul 22, 2026, 11:54 AM EDT
Terminated Phase 2 Interventional

Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal

NCT00333060
View directory record Official record
Conditions
Epiretinal Membrane, Macular Hole
Interventions
OT-551 ophthalmic solution
Drug
Lead sponsor
Othera Pharmaceuticals
Industry
Eligibility
50 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
16
States / cities
Peoria, Arizona • Beverly Hills, California • Sacramento, California + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2008 · Synced Jul 22, 2026, 11:54 AM EDT
Not yet recruiting Not applicable Interventional

The Impact of Physiologic Cataract Surgery on Patient Comfort and Medication Usage

NCT07223866
View directory record Official record
Conditions
Cataract and IOL Surgery, Cataract Surgery Anesthesia, Cataract Surgery Experience, Nuclear Cataract
Interventions
High IOP Setting, Low IOP Setting
Device
Lead sponsor
Matthew Rauen
Other
Eligibility
60 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jul 22, 2026, 11:54 AM EDT
Completed No phase listed Observational

A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract Surgery

NCT04975971
View directory record Official record
Conditions
Anterior Chamber Inflammation, Ocular Pain, Corneal Edema, Corneal Defect, Penetrating KeratoPlasty, Nuclear Cataract, Cortical Cataract, Cataract Senile
Interventions
Dextenza 0.4Mg Ophthalmic Insert
Drug
Lead sponsor
Nicole Fram M.D.
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2021 · Synced Jul 22, 2026, 11:54 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Evaluation of Balanced Salt Solution During Cataract Surgery

NCT05853978
View directory record Official record
Conditions
Fuchs Dystrophy, Cataract
Interventions
BSS Plus, BSS
Drug
Lead sponsor
Adam Fedyk, MD, FACS
Other
Eligibility
22 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Town and Country, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 22, 2026, 11:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis

NCT00023075
View directory record Official record
Conditions
Primary Lateral Sclerosis, Hereditary Spastic Paraplegia, Amyotrophic Lateral Sclerosis
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 11:54 AM EDT
Completed No phase listed Observational

Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System

NCT00078299
View directory record Official record
Conditions
Cataract
Interventions
Not listed
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
Not listed
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 11:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Scheimpflug Photos of the Crystalline Lens in Patients Who Have Undergone Vitrectomy Surgery and Controls

NCT00406263
View directory record Official record
Conditions
Nuclear Sclerotic Cataract
Interventions
Scheimpflug crystalline lens photographs
Procedure
Lead sponsor
Barnes Retina Institute
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 26, 2016 · Synced Jul 22, 2026, 11:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts

NCT00001613
View directory record Official record
Conditions
Cataract
Interventions
Not listed
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
Not listed
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 11:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Phacoemulsification at High IOP and Physiologic IOP: Impact on Anterior and Posterior Segment Physiology

NCT05765201
View directory record Official record
Conditions
Nuclear Cataract
Interventions
High IOP, Low IOP
Other
Lead sponsor
Matthew Rauen
Other
Eligibility
Not listed
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
West Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 7, 2024 · Synced Jul 22, 2026, 11:54 AM EDT