- Conditions
- Opioid-induced Constipation
- Interventions
- Naldemedine, Placebo
- Drug
- Lead sponsor
- Shionogi
- Industry
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 1,246 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2016
- U.S. locations
- 99
- States / cities
- Birmingham, Alabama • Mobile, Alabama • Chandler, Arizona + 96 more
Search Results
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Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.
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Showing 1–24
of 60
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Opioid-Induced Bowel Dysfunction
- Interventions
- Lubiprostone, Placebo
- Drug
- Lead sponsor
- Sucampo Pharma Americas, LLC
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 439 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2009
- U.S. locations
- 94
- States / cities
- Birmingham, Alabama • Hueytown, Alabama • Mobile, Alabama + 79 more
- Conditions
- Opioid-Induced Constipation
- Interventions
- Linaclotide 145 micrograms, Linaclotide 290 micrograms, Placebo
- Drug
- Lead sponsor
- Forest Laboratories
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 254 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2015
- U.S. locations
- 77
- States / cities
- Anniston, Alabama • Foley, Alabama • Phoenix, Arizona + 67 more
- Conditions
- Opioid-Induced Bowel Dysfunction
- Interventions
- Lubiprostone, Placebo
- Drug
- Lead sponsor
- Sucampo Pharma Americas, LLC
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 437 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2009
- U.S. locations
- 109
- States / cities
- Tuscaloosa, Alabama • Phoenix, Arizona • Tempe, Arizona + 93 more
- Conditions
- OIC
- Interventions
- Relistor Injectable Product, Docusate Calcium, Bisacodyl, Milk of magnesia, Magnesium citrate, Senna, Enema
- Drug
- Lead sponsor
- Methodist Health System
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2022
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Constipation
- Interventions
- Lubiprostone, Senna
- Drug
- Lead sponsor
- Shirley Ryan AbilityLab
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 64 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2011
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Advanced Illness Patients With Opioid Induced Constipation
- Interventions
- SC Methylnaltrexone, SC Placebo
- Drug
- Lead sponsor
- Bausch Health Americas, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 154 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2003 – 2005
- U.S. locations
- 1
- States / cities
- Tarrytown, New York
- Conditions
- Constipation
- Interventions
- Methylnaltrexone, Senna, docusate sodium, bisacodyl, magnesium hydroxide, Miralax
- Drug
- Lead sponsor
- Shriners Hospitals for Children
- Other
- Eligibility
- 12 Years to 21 Years
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2015
- U.S. locations
- 1
- States / cities
- Spokane, Washington
- Conditions
- Opioid Induced Constipation
- Interventions
- naloxegol, non-PAMORA
- Drug
- Lead sponsor
- Valinor Pharma LLC
- Industry
- Eligibility
- Not listed
- Enrollment
- 8,800 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2023
- U.S. locations
- 2
- States / cities
- Wilmington, Delaware • Hines, Illinois
- Conditions
- Low Back Pain
- Interventions
- Oxycodone/Naloxone controlled-release, Oxycodone HCl controlled-release, Placebo
- Drug
- Lead sponsor
- Purdue Pharma LP
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 455 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2014
- U.S. locations
- 170
- States / cities
- Alabaster, Alabama • Birmingham, Alabama • Gulf Shores, Alabama + 137 more
- Conditions
- Opioid Induced Constipation
- Interventions
- TD-1211, Placebo
- Drug
- Lead sponsor
- Glycyx Therapeutics
- Industry
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 217 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2012
- U.S. locations
- 1
- States / cities
- Foley, Alabama
- Conditions
- Constipation, Impaction, and Bowel Obstruction, Unspecified Adult Solid Tumor, Protocol Specific
- Interventions
- naloxone hydrochloride
- Drug
- Lead sponsor
- Dana-Farber Cancer Institute
- Other
- Eligibility
- 18 Years to 120 Years
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- Started 2000
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Constipation, Analgesia
- Interventions
- Naloxone and Docusate
- Drug
- Lead sponsor
- CAMC Health System
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 3 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2012
- U.S. locations
- 1
- States / cities
- Charleston, West Virginia
- Conditions
- Constipation
- Interventions
- TD-1211 Dose 1, TD-1211 Dose 2
- Drug
- Lead sponsor
- Glycyx Therapeutics
- Industry
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 47 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2012 – 2013
- U.S. locations
- 1
- States / cities
- San Antonio, Texas
- Conditions
- Opioid-Induced Constipation
- Interventions
- Methylnaltrexone, Placebo
- Drug
- Lead sponsor
- Bausch Health Americas, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 237 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2013
- U.S. locations
- 29
- States / cities
- Mobile, Alabama • Laguna Hills, California • Lancaster, California + 23 more
- Conditions
- OIC
- Interventions
- ALKS 37, Placebo
- Drug
- Lead sponsor
- Alkermes, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 91 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2012
- U.S. locations
- 13
- States / cities
- Anaheim, California • Orange, California • Daytona Beach, Florida + 10 more
- Conditions
- Opioid-induced Constipation
- Interventions
- RDC-1036 (ALKS 37), Placebo
- Drug
- Lead sponsor
- Alkermes, Inc.
- Industry
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010
- U.S. locations
- 11
- States / cities
- Sheffield, Alabama • Anaheim, California • Pasadena, California + 8 more
- Conditions
- Constipation
- Interventions
- N-methylnaltrexone bromide (MOA-728)
- Drug
- Lead sponsor
- Bausch Health Americas, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 1,040 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2010
- U.S. locations
- 94
- States / cities
- Birmingham, Alabama • Chandler, Arizona • Mesa, Arizona + 76 more
- Conditions
- Patients With Opioid Induced Constipation
- Interventions
- Not listed
- Lead sponsor
- AstraZeneca
- Industry
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 520 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2014
- U.S. locations
- 24
- States / cities
- Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 21 more
- Conditions
- Opioid-induced Constipation
- Interventions
- Methylnaltrexone Bromide, Placebo-Normal Saline
- Drug
- Lead sponsor
- St. John Health System, Michigan
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 80 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2010
- U.S. locations
- 1
- States / cities
- Southfield, Michigan
- Conditions
- Osteogenesis Imperfecta Type II, Osteogenesis Imperfecta Type III
- Interventions
- Mesenchymal Stromal Cells
- Biological
- Lead sponsor
- Nationwide Children's Hospital
- Other
- Eligibility
- Up to 19 Years
- Enrollment
- 5 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2014
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Opioid-Induced Bowel Dysfunction
- Interventions
- Lubiprostone 24
- Drug
- Lead sponsor
- Sucampo Pharma Americas, LLC
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 439 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2009
- U.S. locations
- 120
- States / cities
- Birmingham, Alabama • Hueytown, Alabama • Mobile, Alabama + 95 more
- Conditions
- OIC
- Interventions
- TD-1211 IV [C14], TD-1211 PO [C14]
- Drug
- Lead sponsor
- Glycyx Therapeutics
- Industry
- Eligibility
- 18 Years to 50 Years · Male only
- Enrollment
- 10 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2012 – 2013
- U.S. locations
- 1
- States / cities
- Madison, Wisconsin
- Conditions
- Opioid-Induced Constipation
- Interventions
- Methylnaltrexone bromide
- Drug
- Lead sponsor
- Bausch Health Americas, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 156 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2013
- U.S. locations
- 26
- States / cities
- Mobile, Alabama • Laguna Hills, California • Lancaster, California + 20 more