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Showing 1–24 of 756 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Obstructive Sleep Apnea (OSA) Clear all
Completed Phase 3 Interventional

Investigation of a Novel Positive Pressure Therapy to Rescue Patients Failing to Tolerate CPAP During an Initial Encounter

NCT00635206
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
BiPap auto with Fi Flex, Standard CPAP
Device
Lead sponsor
Clayton Sleep Insititute
Industry
Eligibility
21 Years to 75 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 13, 2009 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Neck Grasp as a Predictor of Sleep Apnea

NCT02474823
View directory record Official record
Conditions
Obstructive Sleep Apnea, Type 2 Diabetes
Interventions
polysomnogram, home sleep test, Easy Sleep Apnea Predictor
Other
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed No phase listed Observational

The Prevalence of Sleep Disordered Breathing in Hospitalized Patients With Acutely Decompensated Heart Failure Syndrome

NCT00701519
View directory record Official record
Conditions
Sleep Apnea, Congestive Heart Failure, Heart Failure
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
1,600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Measuring Effectiveness in Sleep Apnea Surgery

NCT00518128
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Surgical OSA treatment, Positive Airway Pressure Therapy
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 21, 2012 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting Phase 2 Interventional

Study to Examine the Effect of Silicone Mouth Tape on Snoring and Mild Sleep Apnea.

NCT06587256
View directory record Official record
Conditions
Mild Obstructive Sleep Apnea, Snoring
Interventions
Mouth Tape
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Validation of Sleep Questionnaires in the Down Syndrome Population

NCT03771469
View directory record Official record
Conditions
Obstructive Sleep Apnea, Down Syndrome
Interventions
Sleep study
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
2 Years to 17 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation Monitor (Exspiron ™ System)

NCT02903173
View directory record Official record
Conditions
Pregnancy, Analgesia, Respiratory Depression, Obstructive Sleep Apnea, Postpartum
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 23, 2019 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional

Cognition After OSA Treatment Among Native American People (CATNAP)

NCT06227572
View directory record Official record
Conditions
Obstructive Sleep Apnea, Cognitive Change
Interventions
CATNAP MI
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
40 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Eagle Butte, South Dakota
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Results available

The Effects of Trazodone on Sleep Apnea Severity

NCT01817907
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Placebo pill, Trazodone
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Influence of Exercise, Weight Loss, and Exercise Plus Weight Loss on Sleep Apnea

NCT02721251
View directory record Official record
Conditions
Obstructive Sleep Apnea, Overweight
Interventions
Exercise, Weight Loss, Exercise + Weight Loss
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Jul 20, 2026, 6:41 PM EDT
Active, not recruiting Not applicable Interventional

Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial

NCT05920694
View directory record Official record
Conditions
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Interventions
Continuous Positive Airway Pressure Device (CPAP), Delayed Continuous Positive Airway Pressure Device (CPAP)
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Enrolling by invitation Not applicable Interventional

LinguaFlex Tongue Retractor (LTR) for the Treatment of OSA and Snoring in Adults

NCT04129229
View directory record Official record
Conditions
Obstructive Sleep Apnea, Snoring
Interventions
LinguaFlex Tongue Retractor (LTR)
Device
Lead sponsor
Linguaflex, Inc.
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
3
States / cities
Brighton, Massachusetts • Morgantown, West Virginia • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Jul 20, 2026, 6:41 PM EDT
Withdrawn Not applicable Interventional

Sleep Apnea in Head and Neck Cancer Patients at the University of Colorado

NCT04922112
View directory record Official record
Conditions
Obstructive Sleep Apnea, Squamous Cell Carcinoma of Head and Neck
Interventions
Obstructive sleep apnea testing
Diagnostic Test
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Jul 20, 2026, 6:41 PM EDT
Completed No phase listed Observational

Use of Blood Biomarkers and Biomarker Index to Aid in the Diagnosis of Obstructive Sleep Apnea (OSA)

NCT03122483
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
blood biomarker
Diagnostic Test
Lead sponsor
Beckman Coulter, Inc.
Industry
Eligibility
18 Years to 70 Years · Male only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
Irvine, California • Boston, Massachusetts • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 17, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Treatment Study of Soft Palatal Implants in Obstructive Sleep Apnea

NCT00263770
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
soft palate implant, Positive airway pressure (PAP)
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 19, 2011 · Synced Jul 20, 2026, 6:41 PM EDT
Completed No phase listed Observational

Postoperative Neurocognitive Disorders

NCT04244162
View directory record Official record
Conditions
Obstructive Sleep Apnea, Neurocognitive Disorders
Interventions
Brain Imaging, Cognitive testing, Blood Biomarkers
Diagnostic Test
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed No phase listed Observational

Rhythm Express Wearable System vs. Simultaneous Polysomnography for the Diagnosis of Obstructive Sleep Apnea in Adults With Suspected or Observed Atrial Fibrillation

NCT06907888
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA), Atrial Fibrillation (Paroxysmal), Palpitations
Interventions
Rhythm Express Wearable System
Device
Lead sponsor
VivaQuant
Industry
Eligibility
21 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
4
States / cities
Conway, Arkansas • St Louis, Missouri • Charlotte, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Ezopiclone Improves the Quality of Overnight Polysomnography

NCT00507117
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Lunesta, Placebo control
Drug
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 29, 2007 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Advancing Understanding of Transportation Options

NCT04141891
View directory record Official record
Conditions
Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa, Vision Disorders, Acute Coronary Syndrome, Implantable Defibrillator User, Congestive Heart Failure, Hypertrophic Obstructive Cardiomyopathy, Orthostatic Hypotension, Syncope, Presyncope, Narcolepsy, Dementia, Multiple Sclerosis, Parkinson Disease, Brain Injuries, Spinal Cord Injuries, Stroke, Vertigo, Dizziness, Seizures, Substance Use, Insulin Dependent Diabetes Mellitus, Arthritis, Foot--Abnormalities, Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, End Stage Renal Disease, Sleep Apnea, Insomnia, Restless Legs Syndrome
Interventions
Driving Decision Aid, Older Drivers Website
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
529 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
3
States / cities
La Jolla, California • Aurora, Colorado • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 1 Interventional

A Study to Assess the Effect of Seltorexant Compared to Placebo on Respiration During Sleep in Adult Participants With Obstructive Sleep Apnea

NCT03796026
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Seltorexant 40 mg, Placebo
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
4
States / cities
Atlanta, Georgia • New York, New York • Cincinnati, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pilot Study of the MultiSense Patch to Record Cardiopulmonary Data During Sleep and Wake Cycles

NCT02222103
View directory record Official record
Conditions
Obstructive Sleep Apnea of Adult
Interventions
Not listed
Lead sponsor
Scripps Translational Science Institute
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Results available

Pilairo Lab Market Research

NCT01824979
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
CPAP mask ( Pilairo), Other CPAP mask
Device · Procedure
Lead sponsor
Fisher and Paykel Healthcare
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Burlingame, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Results available

Stroke and CPAP Outcome Study 3

NCT06029959
View directory record Official record
Conditions
Ischemic Stroke, Intra Cerebral Hemorrhage, Obstructive Sleep Apnea, Adherence, Treatment, Motivation
Interventions
Continuous positive airway pressure (CPAP), CPAP technical support intervention, Motivational Enhancement Therapy (MET), Mobile Health intervention
Device · Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Portable Monitoring for Diagnosis and Management of Sleep Apnea

NCT00642486
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Portable (Embla Embletta X30 system and Respironic REMStar Auto M series with CFlex), Standard polysomnography (PSG)
Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
373 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Jul 20, 2026, 6:41 PM EDT