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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Open Abdominal Surgery Clear all
Completed Phase 4 Interventional

Extended Delivery of Bupivacaine Study in Herniorrhaphy

NCT04102267
View directory record Official record
Conditions
Analgesia
Interventions
Bupivacaine liposome injectable suspension, Bupivacaine HCl without epinephrine via continuous infusion
Drug
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Anaheim, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 3 Interventional

Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus

NCT00002706
View directory record Official record
Conditions
Endometrial Adenocarcinoma, Stage I Uterine Corpus Cancer, Stage I Uterine Sarcoma, Stage II Uterine Corpus Cancer, Stage II Uterine Sarcoma
Interventions
Laparoscopic Surgery, Quality-of-Life Assessment, Therapeutic Conventional Surgery
Procedure · Other
Lead sponsor
Gynecologic Oncology Group
Network
Eligibility
18 Years and older · Female only
Enrollment
2,616 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1996
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

A Study to Compare Ventral Incisional Hernia by Laparoscopic vs Open Repair With Mesh

NCT00240188
View directory record Official record
Conditions
Hernia, Ventral
Interventions
Open mesh repair of ventral incisional hernia, Laparoscopic mesh repair of ventral incisional hernia
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2010 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Phase 2 Interventional

A Study of Radspherin® in Patients With Primary Advanced Epithelial Cancer, With Peritoneal Metastasis That Are Homologous Recombination Proficient Scheduled to Undergo Neoadjuvant Chemotherapy and Interval Debulking Surgery

NCT06504147
View directory record Official record
Conditions
Peritoneal Carcinomatosis, Ovarian Cancer
Interventions
Radspherin
Drug
Lead sponsor
Oncoinvent Solutions AS
Industry
Eligibility
18 Years and older · Female only
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 3 Interventional Results available

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™) for the Treatment of Post-Operative Pain in Patients After Open Abdominal Surgery

NCT01539642
View directory record Official record
Conditions
Post-Operative Pain
Interventions
Sufentanil NanoTab PCA System/15 mcg, Placebo Sufentanil NanoTab PCA System
Drug
Lead sponsor
Talphera, Inc
Industry
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
12
States / cities
Mobile, Alabama • Laguna Hills, California • Stamford, Connecticut + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2015 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 3 Interventional Results available

A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain

NCT01539538
View directory record Official record
Conditions
Post-Operative Pain
Interventions
Sufentanil NanoTab PCA System/15 mcg, morphine IV PCA
Drug
Lead sponsor
Talphera, Inc
Industry
Eligibility
18 Years and older
Enrollment
357 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
16
States / cities
Florence, Alabama • Montgomery, Alabama • Sheffield, Alabama + 13 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2015 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Early Phase 1 Interventional

Digital Meditation for Postoperative Pain Control After Abdominal Surgery for Cancer

NCT05346692
View directory record Official record
Conditions
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Interventions
Survey Administration, Interview, Text Message-Based Navigation Intervention
Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

Effects of Continuous Bilateral QL Analgesia After Open Abdominal Surgery

NCT02684968
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Colorectal surgery
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 8, 2021 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 3 Interventional Results available

Study of Post-Herniorrhaphy Non-opioid MMA Regimens

NCT03907176
View directory record Official record
Conditions
Analgesia
Interventions
HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
30
States / cities
Anaheim, California • La Mesa, California • Orange, California + 22 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Surgisis Gold Graft for Incision Reinforcement After Open Bariatric Surgery

NCT00274625
View directory record Official record
Conditions
Hernia, Obesity
Interventions
Surgisis Gold Graft, Control
Device · Procedure
Lead sponsor
Cook Group Incorporated
Industry
Eligibility
18 Years and older
Enrollment
402 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
2
States / cities
Rochester, Minnesota • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 11, 2014 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 4 Interventional Results available

Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA)

NCT00094575
View directory record Official record
Conditions
Aortic Aneurysm
Interventions
Endovascular Repair, Standard Open Repair
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
881 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2012
U.S. locations
42
States / cities
Birmingham, Alabama • Tucson, Arizona • No. Little Rock, Arkansas + 39 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2016 · Synced Jul 24, 2026, 2:49 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Preemptive Use of the Nicotine Patch for Postoperative Pain Relief After Open Abdominal Surgery

NCT00790829
View directory record Official record
Conditions
Postoperative Pain
Interventions
transdermal nicotine patch
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jan 20, 2022 · Synced Jul 24, 2026, 2:49 AM EDT
Not listed No phase listed Observational

Stem Cells Found in the Abdominal Cavity in Humans

NCT00576264
View directory record Official record
Conditions
Intra-abdominal Surgery
Interventions
Not listed
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 26, 2011 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 2 Interventional

Safety and Efficacy of IV Infusion of TZP-101 for POI After Major Open Abdominal Surgery

NCT00617552
View directory record Official record
Conditions
Postoperative Ileus
Interventions
5% dextrose in water, TZP-101
Drug
Lead sponsor
Tranzyme, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
10
States / cities
Los Angeles, California • Miami, Florida • Ocala, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 6, 2012 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

Individualized Perioperative Open Lung Ventilatory Strategy

NCT02158923
View directory record Official record
Conditions
Moderated-high Risk of Postoperative Pulmonary Complication, Abdominal Surgery Expected More Than Two Hours
Interventions
Alveolar recruitment maneuver, Calculation of optimal PEEP, Postoperative CPAP
Procedure
Lead sponsor
Fundación para la Investigación del Hospital Clínico de Valencia
Other
Eligibility
18 Years and older
Enrollment
920 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Jul 24, 2026, 2:49 AM EDT
Active, not recruiting Not applicable Interventional

Assessment of a Non-invasive Device in the Management of Open Abdomen (AbCLO)

NCT06242925
View directory record Official record
Conditions
Open Abdomen
Interventions
AbCLO (Abdominal Wall Closure) Device
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Los Angeles, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 3 Interventional

An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries

NCT04785638
View directory record Official record
Conditions
Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy, Colectomy, Reduction Mammoplasty
Interventions
INL-001 (bupivacaine hydrochloride) implant
Combination Product
Lead sponsor
Innocoll
Industry
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
8
States / cities
Florence, Alabama • Sheffield, Alabama • Pasadena, California + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2023 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

The EVARREST® Pediatric Mild or Moderate Liver and Soft Tissue Bleeding Study

NCT03255174
View directory record Official record
Conditions
Controlling Mild to Moderate Bleeding During Surgery
Interventions
EVARREST® Fibrin Sealant Patch
Biological
Lead sponsor
Ethicon, Inc.
Industry
Eligibility
28 Days to 17 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
2
States / cities
Birmingham, Alabama • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Withdrawn Not applicable Interventional

An Adhesion Reduction Plan in the Management of the Surgical Open Abdomen

NCT01010464
View directory record Official record
Conditions
Open Abdomen
Interventions
Adhesion Reduction Plan
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2020 · Synced Jul 24, 2026, 2:49 AM EDT
Suspended Not applicable Interventional

Direct Resuscitation of the Open Peritoneum

NCT04887480
View directory record Official record
Conditions
Wound; Abdomen, Abdomen, Acute, Wound Surgical
Interventions
Abthera™ Open Abdomen Negative Pressure Therapy Device System, Dianeal PD-2 with 2.5% Dextrose
Device · Drug
Lead sponsor
Sanford Health
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

Transluminal Flexible Endoscopic Procedure in Foregut and Urologic Surgery

NCT00484783
View directory record Official record
Conditions
Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder), Foreign Body in Esophagus, Prostatic Diseases, Disease of Small Intestine
Interventions
Natural Orifice Transluminal Endoscopic Surgery (NOTES), Natural Orifice Translumenal Endoscopic Surgery (NOTES)
Procedure
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 15, 2014 · Synced Jul 24, 2026, 2:49 AM EDT
Terminated Not applicable Interventional Results available

An Evaluation of SprayShield in Reducing Post-Operative Adhesion Formation Following Major Open Abdominal Surgery

NCT01002287
View directory record Official record
Conditions
Ulcerative Colitis, Familial Polyposis
Interventions
SprayShield Adhesion Barrier System, Good Surgical Technique Alone
Device · Procedure
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Jul 24, 2026, 2:49 AM EDT
Terminated Not applicable Interventional Results available

Hemodynamic Response During Goal Directed Fluid Therapy in the OR

NCT02365688
View directory record Official record
Conditions
Hemodynamic Instability
Interventions
Initial bolus pre-incision
Procedure
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2017 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Exparel Use in Bilateral TAP Blocks for Postoperative Pain Control

NCT03878888
View directory record Official record
Conditions
Postoperative Pain, Surgery, Anesthesia, Local
Interventions
Exparel 266 MG Per 20 ML Injection
Drug
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Jul 24, 2026, 2:49 AM EDT