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ClinicalTrials.gov public records Last synced Oct 24, 2026, 8:14 PM EDT

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Showing 841–864 of 1,479 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Opioid Related Disorders Clear all
Recruiting Not applicable Interventional

Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

NCT06872190
View directory record Official record
Conditions
Opioid Use Disorder, Social Determinants of Health (SDOH)
Interventions
ED-Based Clinical Decision Support for Opioid Use Disorder, Social Care-Enhanced Clinical Decision Support for Opioid Use Disorder
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 2 Interventional Results available

Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans

NCT02539823
View directory record Official record
Conditions
Opiate Addiction
Interventions
CBD 400 mg, CBD 800 mg, Control (placebo)
Drug
Lead sponsor
Hurd,Yasmin, Ph.D.
Individual
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting Phase 2 Interventional

E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder

NCT05722561
View directory record Official record
Conditions
Opioid Use Disorder, Cigarette Smoking
Interventions
Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).
Behavioral · Drug · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 75 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Averting NAS Among Opioid-Using Young Women Receiving MAT Using Buprenorphine

NCT04611659
View directory record Official record
Conditions
Opioid-use Disorder, Contraception, Neonatal Abstinence Syndrome
Interventions
Motivational Interviewing and Educational Training (MIET)
Behavioral
Lead sponsor
Meharry Medical College
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 3 Interventional

Lofexidine for Inpatient Opiate Detox

NCT00235729
View directory record Official record
Conditions
Opiate Addiction
Interventions
Lofexidine, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
16
States / cities
Cerritos, California • Washington D.C., District of Columbia • Atlanta, Georgia + 13 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2009 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting No phase listed Observational

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

NCT07232641
View directory record Official record
Conditions
Substance Use Disorders, Alcohol Use Disorder, Opioid Use Disorder
Interventions
Not listed
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
185,810 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Active, not recruiting No phase listed Observational

Leveraging Artificial Intelligence and Multi-Omics Data to Predict Opioid Addiction

NCT06540105
View directory record Official record
Conditions
Opioid Use Disorder, Addiction, Opioid
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Organization-level Youth Engagement Approach for Substance Misuse Prevention

NCT05736211
View directory record Official record
Conditions
Drug Use, Substance Use, Opioid Use, Substance Misuse
Interventions
Organization-level Youth Engagement prevention strategy
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting Phase 1 Interventional

Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder

NCT07158853
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting Phase 2 Interventional

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

NCT06067737
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Psilocybin
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 70 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 1 Interventional

Mindfulness-Oriented Recovery Enhancement for Chronic Pain Patients Receiving Opioid Therapy

NCT01505101
View directory record Official record
Conditions
Chronic Pain, Opioid Abuse, Unspecified Use
Interventions
Mindfulness-Oriented Recovery Enhancement, Conventional Support Group (SG)
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 6, 2014 · Synced Oct 24, 2026, 8:14 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Pioglitazone to Treat Opioid Withdrawal Symptoms

NCT01517165
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Pioglitazone, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 24, 2026, 8:14 PM EDT
Completed No phase listed Observational

ALK21-025: Vivitrol's Cost and Treatment Outcomes Registry

NCT01422837
View directory record Official record
Conditions
Opioid Dependence
Interventions
Not listed
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
18 Years and older
Enrollment
403 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
31
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Ben Lomond, California + 26 more
Source: ClinicalTrials.gov public record
Updated Nov 16, 2018 · Synced Oct 24, 2026, 8:14 PM EDT
Not yet recruiting Not applicable Interventional

Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation

NCT07842601
View directory record Official record
Conditions
Opioid Use Disorder, Major Depressive Disorder (MDD)
Interventions
Transcranial Magnetic Stimulation (TMS), Sham Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Active, not recruiting Phase 3 Interventional

Telemedicine XR-B for Individuals in Jail

NCT07524738
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Extended Release Buprenorphine
Drug
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Cumberland, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Not applicable Interventional

More Individualized Care: Assessment and Recovery Through Engagement

NCT05122676
View directory record Official record
Conditions
Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
Interventions
More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
805 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Indianapolis, Indiana • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 1 Interventional Results available

Opioid and Cannabinoid Interactions

NCT03705559
View directory record Official record
Conditions
Marijuana Usage, Opioid Use
Interventions
Vaporized Marijuana, Opioid Agonist, Placebo
Drug
Lead sponsor
Shanna Babalonis, PhD
Other
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 1 Interventional

Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain

NCT02372591
View directory record Official record
Conditions
Opioid-Related Disorders, Chronic Pain
Interventions
Buprenorphine, Hydromorphone, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2017 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 1Phase 2 Interventional

Assessment of Tramadol as a Treatment for Opioid Addiction

NCT00301210
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Tramadol
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 17, 2015 · Synced Oct 24, 2026, 8:14 PM EDT
Enrolling by invitation Not applicable Interventional

Measurement Based Care in Opioid Treatment Programs

NCT06965010
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Measurement-based care, Measurement As Usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
3,650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Not yet recruiting Not applicable Interventional

Measurement-Based Care to Support Buprenorphine-Naloxone Treatment in Outpatient Addiction Clinics

NCT07839182
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Bup-MBC
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 2 Interventional Results available

Safety and Tolerability of Buprenorphine/Naloxone Film Strips

NCT00640835
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Buprenorphine/naloxone Film Strip
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
382 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
3
States / cities
Birmingham, Alabama • Haleyville, Alabama • Jacksonville Beach, Florida
Source: ClinicalTrials.gov public record
Updated Nov 12, 2012 · Synced Oct 24, 2026, 8:14 PM EDT
Terminated Not applicable Interventional Results available

Imaging the Effects of rTMS on Chronic Pain

NCT02687360
View directory record Official record
Conditions
Chronic Pain, Opioid-use Disorder
Interventions
Active rTMS treatment, Sham rTMS treatment
Device
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

NCT05547048
View directory record Official record
Conditions
HIV, Opioid Use Disorder, eHealth
Interventions
Decision Aid, Athena strategy
Behavioral · Combination Product
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 24, 2026, 8:14 PM EDT