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ClinicalTrials.gov public records Last synced Oct 16, 2026, 2:31 AM EDT

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Showing 673–696 of 1,212 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteoarthritis, Knee Clear all
Not listed Phase 2Phase 3 Interventional

The Influence Of a Natural Anti-Inflammatory Product On Levels Of Inflammatory Markers In Cases With Osteoarthritis Of Knee

NCT02333084
View directory record Official record
Conditions
Osteoarthritis
Interventions
PRN Joint Health Formula, placebo, PRN Flex Omega Benefits® combination
Dietary Supplement
Lead sponsor
Physician Recommended Nutriceuticals
Industry
Eligibility
18 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 4, 2016 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Phase 4 Interventional Results available

Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200

NCT03124407
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Capsaicin Topical Solution, Drug product vehicle
Drug · Other
Lead sponsor
Propella Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
3
States / cities
Clearwater, Florida • Tampa, Florida • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 31, 2024 · Synced Oct 16, 2026, 2:31 AM EDT
Recruiting No phase listed Observational

Innovations in Genicular Outcomes Registry

NCT05495334
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Treatment for Knee OA
Procedure
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
Not listed
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2033
U.S. locations
19
States / cities
Phoenix, Arizona • Irvine, California • Los Angeles, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Phase 3 Interventional Results available

Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain

NCT04231318
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Cingal, Triamcinolone Hexacetonide (TH), Placebo
Drug
Lead sponsor
Anika Therapeutics, Inc.
Industry
Eligibility
40 Years to 75 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
26
States / cities
Chandler, Arizona • Tucson, Arizona • Anaheim, California + 21 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2023 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Not applicable Interventional

Minimally Invasive Knee Replacement Outcomes (MIKRO) Study

NCT00633113
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
MPPA, SV
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
35 Years to 85 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 29, 2013 · Synced Oct 16, 2026, 2:31 AM EDT
Recruiting Not applicable Interventional

Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

NCT04875052
View directory record Official record
Conditions
Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy
Interventions
Experimental: Whole Body Vibration, Experimental: Local Muscle Vibration, Standard ACL Rehabilitation
Device · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 35 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 31, 2025 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobilizing Hispanics With Knee Osteoarthritis

NCT06522906
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Muscle Strengthening, General Physical Activity, Education
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 90 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 16, 2026, 2:31 AM EDT
Withdrawn Early Phase 1 Interventional

Bioavailability and Pharmacokinetic Measures of H. Procumbens Extract

NCT03641248
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Enteric coated Devil's Claw, Non-enteric coated Devil's Claw
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Phase 1 Interventional

Phase 1, Dose Escalation Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SM04690 in Moderate to Severe Knee Osteoarthritis (OA)

NCT02095548
View directory record Official record
Conditions
Moderate to Severe Osteoarthritis
Interventions
SM04690, 0.03mg/2mL, SM04690, 0.07mg/2mL, SM04690, 0.23mg/2mL, Placebo
Drug
Lead sponsor
Biosplice Therapeutics, Inc.
Industry
Eligibility
50 Years to 75 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
7
States / cities
Tucson, Arizona • El Cajon, California • Walnut Creek, California + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2015 · Synced Oct 16, 2026, 2:31 AM EDT
Completed No phase listed Observational Results available

Kinematics in Posterior Cruciate Retaining and Bi-Cruciate Retaining Total Knee Replacements

NCT03088748
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Interventions
Journey II posterior cruciate retaining total knee arthroplasty, Journey II posterior bi-cruciate retaining total knee arthroplasty
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
40 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
4
States / cities
Chattanooga, Tennessee • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial

NCT04210986
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Fisetin, Placebo oral capsule
Dietary Supplement · Drug
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
40 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Phase 3 Interventional

Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis

NCT01112722
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Apitox, purified honeybee toxin, lyophilized in saline, histamine
Biological
Lead sponsor
Apimeds, Inc.
Industry
Eligibility
30 Years to 85 Years
Enrollment
363 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
15
States / cities
Gulf Shores, Alabama • Tucson, Arizona • Garden Grove, California + 11 more
Source: ClinicalTrials.gov public record
Updated Dec 13, 2016 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Not applicable Interventional

Mind-body Therapy (Remotely Delivered) for Knee Osteoarthritis

NCT04678999
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Mind-body exercise and education
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 16, 2026, 2:31 AM EDT
Completed No phase listed Observational

Conjoint Analysis of Treatment Preferences for Osteoarthritis

NCT01003925
View directory record Official record
Conditions
Osteoarthritis
Interventions
Standard of care for osteoarthritis treatment, Conjoint Analysis for Osteoarthritis
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
65 Years to 95 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2015 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Not applicable Interventional Results available

Calypso Knee System Clinical Study

NCT03671213
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Calypso Knee System (Implantable Shock Absorber)
Device
Lead sponsor
Moximed
Industry
Eligibility
25 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
5
States / cities
Columbia, Missouri • New York, New York • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Feasibility of High Intensity Interval Training in Knee Osteoarthritis

NCT03281668
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
High intensity interval training (HIIT)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 22, 2019 · Synced Oct 16, 2026, 2:31 AM EDT
Terminated Phase 2 Interventional Results available

A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA

NCT05462990
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
QUC398, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
40 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
3
States / cities
Tampa, Florida • Boston, Massachusetts • Morehead City, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 16, 2026, 2:31 AM EDT
Terminated No phase listed Observational

A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System

NCT01820650
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
iTotal G2 CR Knee Replacement System
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
9
States / cities
Atlantis, Florida • Bangor, Maine • Battle Creek, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 16, 2026, 2:31 AM EDT
Active, not recruiting Phase 2 Interventional

53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee

NCT06865079
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
TPX-100 200mg, Once weekly for 4 weeks, PBS
Drug · Other
Lead sponsor
OrthoTrophix, Inc
Industry
Eligibility
50 Years to 80 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
33
States / cities
Scottsdale, Arizona • Tucson, Arizona • Carrolton, California + 26 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 16, 2026, 2:31 AM EDT
Active, not recruiting Phase 3 Interventional

Dronabinol After Arthroscopic Surgery

NCT05335252
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Injuries, Meniscus Tear, Synovitis of Knee, Knee Ligament Injury, Chondral Injury of Left Knee, Chondral Injury of Right Knee, Loose Body Knee
Interventions
Dronabinol, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Phase 2 Interventional Results available

Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA

NCT03378076
View directory record Official record
Conditions
Bilateral Knee Osteoarthritis
Interventions
FX006 32 mg, TAcs 40 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
3
States / cities
Torrance, California • Rochester, New York • Duncansville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Not applicable Interventional

A Pragmatic Trial To Determine the Benefit of Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee

NCT03835910
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Social Incentives and Gamification to Promote Exercise, Corticosteroid Injection given in A-B order, No Social Incentive applied, Corticosteroid Injection given in B-A order
Behavioral · Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
40 Years to 80 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 27, 2021 · Synced Oct 16, 2026, 2:31 AM EDT
Recruiting Phase 2 Interventional

The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis

NCT06911359
View directory record Official record
Conditions
Knee Osteoarthritis (OA)
Interventions
Participants are given Ibuprofen 400 mg to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times., Participants are given a placebo to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times.
Drug
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
45 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Travis AFB, California
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 16, 2026, 2:31 AM EDT
Completed Phase 3 Interventional Results available

Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee

NCT02528188
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
Interventions
NSAID, Tanezumab 2.5 mg, Tanezumab 5 mg
Drug · Biological
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
3,021 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
299
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 187 more
Source: ClinicalTrials.gov public record
Updated Jan 10, 2020 · Synced Oct 16, 2026, 2:31 AM EDT