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Showing 1–24 of 1,210 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Osteoarthritis,Knee Clear all
Completed Not applicable Interventional Results available

Periosteal Stimulation for Knee Osteoarthritis

NCT00865046
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Periosteal stimulation, Control-Periosteal Stimulation
Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
50 Years to 89 Years
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 25, 2015 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Phase 2 Interventional

A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees

NCT01925261
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
TPX-100 50mg, TPX-100 100mg, TPX-100 200mg, TPX-100 20mg, Placebo
Drug
Lead sponsor
OrthoTrophix, Inc
Industry
Eligibility
25 Years to 75 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Genicular Artery Embolization to Reduce Pain Associated With Unilateral Mild to Moderate Osteoarthritis

NCT04592562
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
the Terumo Hydropearl® microspheres device
Device
Lead sponsor
University of Chicago
Other
Eligibility
40 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 3, 2024 · Synced Sep 22, 2026, 10:06 PM EDT
Completed No phase listed Observational

Understanding the Differences in the Management of Patients With Arthritis of the Knee or Hip

NCT00105677
View directory record Official record
Conditions
Osteoarthritis, Arthritis, Degenerative, Osteoarthritis, Hip, Osteoarthritis, Knee
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
50 Years to 79 Years
Enrollment
980 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Pittsburgh, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation

NCT04269239
View directory record Official record
Conditions
Insomnia, Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Healthy Habits, Sleep Habits
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
40 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Galveston, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Obesity and the Initiation of Knee Osteoarthritis

NCT00856739
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
20 Years to 60 Years
Enrollment
177 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating the Impact of a Shared Decision-Making Tool

NCT05411939
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Shared Decision-Making Tool, Video, Standard of Care
Other
Lead sponsor
Yale University
Other
Eligibility
45 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
3
States / cities
Guilford, Connecticut • Milford, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

The Kaia Hip and Knee Pain Intervention for Self-management of the Pain in Patients With Osteoarthritis.

NCT04615377
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis
Interventions
Kaia hip and knee pain application, Treatment as usual
Behavioral · Other
Lead sponsor
Kaia Health Software
Industry
Eligibility
22 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 15, 2022 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Brief Nurse-led Mindfulness Based Intervention

NCT04800354
View directory record Official record
Conditions
Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Nurse-led Mindfulness Based Intervention, Nurse-led Pain Psychoeducation
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 22, 2026, 10:06 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee

NCT02844751
View directory record Official record
Conditions
Osteoarthritis
Interventions
[StroMed + platelet rich plasma (PRP)], [PRP] platelet rich plasma
Biological
Lead sponsor
VivaTech International, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
4,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
Grove City, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Phase 1 Interventional

Double-Blind, Randomized, Single Dose Escalation Safety Study of Intraarticular Bone Morphogenic Protein (38A BMP-7) in Subjects With Osteoarthritis (OA) of the Knee

NCT01133613
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Bone morphogenetic protein 7
Drug
Lead sponsor
Stryker Biotech
Industry
Eligibility
40 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Gainesville, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 31, 2012 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

Knee Biofeedback Rehabilitation Interface for Game-based Home Therapy for Patients With Knee Osteoarthritis

NCT04187092
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
KneeBright Group, Standard Rehabilitation group
Other
Lead sponsor
University of Virginia
Other
Eligibility
40 Years to 75 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Sep 22, 2026, 10:06 PM EDT
Recruiting No phase listed Observational

Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

NCT06781463
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
Interventions
Registry (N/A)
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

Conventional Alignment System Versus Surgical Navigation System in Total Knee Arthroplasty

NCT01797731
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Digital hand-held surgical navigation system, Conventional tibial extramedullary alignment system
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Phase 2Phase 3 Interventional Results available

AMZ001 for the Treatment of Knee Osteoarthritis Symptoms

NCT03691844
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
AMZ001, Placebo, Comparator
Drug
Lead sponsor
Amzell
Industry
Eligibility
40 Years to 85 Years
Enrollment
444 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Milford, Connecticut • The Villages, Florida • Williamsville, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis

NCT00426621
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Diclofenac Sodium Gel, Placebo
Drug
Lead sponsor
Novartis
Industry
Eligibility
35 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
64
States / cities
Mobile, Alabama • Tallassee, Alabama • Chandler, Arizona + 59 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2007 · Synced Sep 22, 2026, 10:06 PM EDT
Terminated Not applicable Interventional

Improving Walking Quality and Quantity in Osteoarthritis (IWALQQ-OA)

NCT03064139
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
MCG, SCG
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
50 Years to 80 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Outcomes Following Suction Drain and Non-suction Drain Assisted Total Knee Arthroplasty

NCT02693457
View directory record Official record
Conditions
Osteoarthritis, Bilateral Total Knee Arthroplasty
Interventions
Drain, No Drain
Procedure
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
Up to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Sep 22, 2026, 10:06 PM EDT
Enrolling by invitation No phase listed Observational

Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK

NCT04145401
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Revision Knee implants
Device
Lead sponsor
MicroPort Orthopedics Inc.
Industry
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2033
U.S. locations
1
States / cities
Englewood, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Phase 3 Interventional

Ketoprofen Topical Patch, 20% in the Treatment of Pain Associated With Osteoarthritis Flare of the Knee

NCT00365586
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ketoprofen Topical Patch , 20%
Drug
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Phase 4 Interventional

Safety and Efficacy of Celecoxib Versus Placebo in the Treatment of Knee Osteoarthritis in Patients Who Were Unresponsive to Naproxen and Ibuprofen

NCT00638807
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Celecoxib, Placebo
Drug · Other
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
40 Years and older
Enrollment
388 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
33
States / cities
Birmingham, Alabama • Buena Park, California • Denver, Colorado + 28 more
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

Delaware Physical Exercise and Activity for Knee Osteoarthritis

NCT04980300
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Intervention, Control
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
45 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Dec 31, 2024 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

Self-Administered Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis

NCT04016272
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 85 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

Brain Morphometry in OA Patients Treated With Duloxetine

NCT02903238
View directory record Official record
Conditions
Pain, Osteoarthritis
Interventions
Duloxetine, Placebo Oral Tablet
Drug
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 85 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 6, 2017 · Synced Sep 22, 2026, 10:06 PM EDT