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ClinicalTrials.gov public records Last synced Oct 12, 2026, 10:39 PM EDT

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Showing 169–192 of 207 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteopenia, Osteoporosis Clear all
Completed No phase listed Observational

Thiazolidinediones (TZD) Bone Loss and the Effects on Bone Marrow Differentiation and Osteoblast Formation

NCT00663143
View directory record Official record
Conditions
Osteoporosis
Interventions
Stromal Cells Sample
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 1, 2015 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 4 Interventional Results available

Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA Trial

NCT01400516
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Teriparatide, calcium citrate, Vitamin D, TNF antagonist
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
3
States / cities
Boston, Massachusetts • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Effect of a Ghrelin Receptor Agonist on Muscle and Bone

NCT04021706
View directory record Official record
Conditions
Sarcopenia, Osteopenia
Interventions
Anamorelin Hydrochloride, Placebo
Drug
Lead sponsor
Tufts University
Other
Eligibility
50 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 27, 2024 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of Vitamin D Supplementation on Lactation Associated Bone Loss

NCT00903344
View directory record Official record
Conditions
Osteoporosis
Interventions
Vitamin D3, Multivitamin
Drug · Dietary Supplement
Lead sponsor
Leigh Eck, MD
Other
Eligibility
18 Years and older · Female only
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2014 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 3 Interventional

A Study of the Clinical Safety, Tolerability, and Efficacy of Zoledronic Acid Compared to an Oral Bisphosphonate

NCT00100555
View directory record Official record
Conditions
Osteoporosis
Interventions
zoledronic acid
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
45 Years to 79 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
18
States / cities
Birmingham, Alabama • San Diego, California • Denver, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2012 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 2 Interventional Results available

Phase 2 Safety and Efficacy Study of a Vitamin D Compound (DP001) in Postmenopausal Women With Low Bone Mineral Density

NCT00715676
View directory record Official record
Conditions
Osteoporosis
Interventions
Placebo, DP001
Drug
Lead sponsor
Deltanoid Pharmaceuticals
Industry
Eligibility
55 Years to 80 Years · Female only
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
9
States / cities
Upland, California • Indianapolis, Indiana • Bethesda, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2010 · Synced Oct 12, 2026, 10:39 PM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

Bone Development in Adolescent Girls: Effects of Calcium and Exercise

NCT00063011
View directory record Official record
Conditions
Osteoporosis
Interventions
Calcium rich diet, Weight bearing exercise
Behavioral
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
9 Years to 10 Years · Female only
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1998
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Not applicable Interventional

Effect of Androgen Suppression on Bone Loss in Patients With or Without Bone Metastases Secondary to Prostate Cancer

NCT00003903
View directory record Official record
Conditions
Osteoporosis, Prostate Cancer
Interventions
management of therapy complications
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
Male only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2007
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 16, 2013 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Melatonin-Micronutrients for Osteopenia Treatment Study

NCT01870115
View directory record Official record
Conditions
Osteoporosis, Osteopenia
Interventions
Fiber Pill, Melatonin, Strontium citrate, Vitamins D3 and K2
Dietary Supplement
Lead sponsor
Duquesne University
Other
Eligibility
Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Oct 12, 2026, 10:39 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Prunes Preventing Bone Loss in Perimenopause

NCT07120997
View directory record Official record
Conditions
Perimenopausal Bone Loss
Interventions
Prunes, Calcium supplement, Vitamin D Supplement
Dietary Supplement
Lead sponsor
Penn State University
Other
Eligibility
44 Years to 55 Years · Female only
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 12, 2026, 10:39 PM EDT
Withdrawn Phase 2 Interventional

Effect of Reducing Nucleotide Exposure on Bone Health (ReNew)

NCT03549689
View directory record Official record
Conditions
HIV/AIDS, HIV-1-infection, Osteopenia
Interventions
Dolutegravir (DTG) 50MG/lamivudine (3TC) 300MG FIXED DOSE COMBINATION (FDC), Current tenofovir alafenamide (TAF)-containing ART regimen
Drug
Lead sponsor
Philip Grant
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
10
States / cities
Birmingham, Alabama • Palo Alto, California • Aurora, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Oct 12, 2026, 10:39 PM EDT
Not listed Phase 2Phase 3 Interventional

Network Osteoporosis Study

NCT00209469
View directory record Official record
Conditions
Osteopenia, Osteoporosis
Interventions
alendronate sodium
Drug
Lead sponsor
Glaser Pediatric Research Network
Network
Eligibility
8 Years to 22 Years
Enrollment
90 participants
Timeline
2002 – 2007
U.S. locations
4
States / cities
Los Angeles, California • San Francisco, California • Stanford, California + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2005 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Magnesium Supplementation to Prevent Bone Loss

NCT00346658
View directory record Official record
Conditions
Osteoporosis
Interventions
magnesium
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
55 Years to 75 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 15, 2008 · Synced Oct 12, 2026, 10:39 PM EDT
Completed No phase listed Observational

Bone Disease in Chronic Pancreatitis: A Complex Phenomenon

NCT02108509
View directory record Official record
Conditions
Chronic Pancreatitis, Osteopenia, Osteoporosis
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 75 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults

NCT00357214
View directory record Official record
Conditions
Osteoporosis, Sarcopenia
Interventions
Potassium Bicarbonate, Sodium Bicarbonate, Potassium Chloride, placebo (microcrystalline cellulose)
Dietary Supplement
Lead sponsor
Tufts University
Other
Eligibility
50 Years and older
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Oct 12, 2026, 10:39 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

NCT07083557
View directory record Official record
Conditions
Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure, MASH, Sarcopenia, Osteoporosis, Hyperparathyroidism, Hypoparathyroidism, Ischemic Heart Disease, Cystic Fibrosis (CF), Chronic Kidney Disease(CKD), Osteopenia, Cachexia
Interventions
Endothelial cell collection
Other
Lead sponsor
Bettina Mittendorfer
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2030
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 3 Interventional Results available

Zoledronic Acid - Letrozole Adjuvant Synergy Trial (ZFAST) - Cancer Treatment Related Bone Loss in Postmenopausal Women With Estrogen Receptor Positive and/or Progesterone Receptor Positive Breast Cancer Receiving Adjuvant Hormonal Therapy

NCT00050011
View directory record Official record
Conditions
Breast Neoplasms, Osteoporosis
Interventions
Zoledronic Acid, Letrozole
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 85 Years · Female only
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2009
U.S. locations
43
States / cities
Springdale, Arkansas • Burbank, California • Lafayette, California + 39 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2014 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 2 Interventional Results available

Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa

NCT00283595
View directory record Official record
Conditions
Anorexia Nervosa, Osteopenia, Osteoporosis, Eating Disorders
Interventions
Recombinant Human Growth Hormone, Placebo for Recombinant Human Growth Hormone
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 45 Years · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Oct 12, 2026, 10:39 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Bone UltraSonic Scanner (BUSS): Validation Study

NCT01439139
View directory record Official record
Conditions
Osteoporosis, Osteopenia
Interventions
Not listed
Lead sponsor
Artann Laboratories
Industry
Eligibility
50 Years to 90 Years · Female only
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 28, 2014 · Synced Oct 12, 2026, 10:39 PM EDT
Completed No phase listed Observational

Genzyme Osteopenia/Osteoporosis Study

NCT02785744
View directory record Official record
Conditions
Gaucher Disease
Interventions
Gaucher disease DNA mutation analysis
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 3 Interventional

Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer

NCT00022087
View directory record Official record
Conditions
Breast Cancer, Osteoporosis
Interventions
calcium salts, cholecalciferol, zoledronic acid
Dietary Supplement · Drug
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
40 Years and older · Female only
Enrollment
439 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
107
States / cities
Arroyo Grande, California • La Jolla, California • Mountain View, California + 80 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2016 · Synced Oct 12, 2026, 10:39 PM EDT
Not listed Not applicable Interventional

Study of an Intervention to Improve Problem List Accuracy and Use

NCT01105923
View directory record Official record
Conditions
Attention Deficit Disorder With Hyperactivity, Asthma, COPD, Breast Cancer, Coronary Artery Disease, Congestive Heart Failure, Diabetes, Glaucoma, Hemophilia, Hypertension, Hyperthyroidism, Hypothyroidism, Myasthenia Gravis, Osteoporosis, Osteopenia, Renal Failure, Renal Insufficiency, Sickle Cell Disease, Stroke
Interventions
MAPLE
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2015 · Synced Oct 12, 2026, 10:39 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Effect of Calcium and Vitamin D on Bone Loss From the Hip

NCT00357643
View directory record Official record
Conditions
Osteoporosis
Interventions
Calcium 500 mg/day and vitamin D 700 IU/day
Drug
Lead sponsor
Tufts University
Other
Eligibility
65 Years and older
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 1996
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2006 · Synced Oct 12, 2026, 10:39 PM EDT
Terminated Phase 2 Interventional Results available

The Effects of Estrogen Replacement Therapy in Postmenopausal Women With Hypercalciuria and Low Bone Mass

NCT01928082
View directory record Official record
Conditions
Hypercalciuria, Hypercalciuria, Familial Idiopathic, Osteopenia, Osteoporosis
Interventions
Transdermal estradiol
Drug
Lead sponsor
University of Chicago
Other
Eligibility
40 Years to 69 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Oct 12, 2026, 10:39 PM EDT