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ClinicalTrials.gov public records Last synced Oct 24, 2026, 8:35 AM EDT

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Showing 1–24 of 1,798 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain, Musculoskeletal Clear all
Completed Not applicable Interventional Results available

Pain Rehabilitation Virtual Reality (PRVR): Innovations to Enhance Mobility in the Presence of Pain

NCT04636177
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain, Fibromyalgia, Virtual Reality
Interventions
Pain Rehabilitation Virtual Reality (PRVR), Standard Physiotherapy Rehabilitation (SPR)
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
10 Years to 17 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Menlo Park, California • Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional

Post-Operative Pain Control Following Shoulder Surgery

NCT04622839
View directory record Official record
Conditions
Shoulder Pain
Interventions
Tylenol and NSAIDS (Ibuprofen, diclofenac)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 16, 2023 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Phase 3 Interventional Results available

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

NCT05139030
View directory record Official record
Conditions
Knee Osteoarthritis, Pain Management
Interventions
bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
6
States / cities
Little Rock, Arkansas • Pasadena, California • Dayton, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2024 · Synced Oct 24, 2026, 8:35 AM EDT
Suspended Not applicable Interventional

Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity

NCT05956067
View directory record Official record
Conditions
Chronic Low-back Pain, Chronic Pain, Fibromyalgia
Interventions
Green Light stimulation, Equal Energy White stimulation, S-cone modulating white light
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional

Platelet-rich Plasma in the Sacroiliac Joint

NCT03744234
View directory record Official record
Conditions
Sacroiliac Joint Arthritis
Interventions
PRP, Steroid Injection
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Oct 24, 2026, 8:35 AM EDT
Terminated Not applicable Interventional Results available

Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain

NCT00716807
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction Syndrome, Burning Mouth Syndrome
Interventions
nalbuphine plus naloxone, nalbuphine plus placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 20, 2016 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Phase 3 Interventional Results available

Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee

NCT00531427
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis of the Knee
Interventions
Buprenorphine, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
40 Years and older
Enrollment
567 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
87
States / cities
Mobile, Alabama • Chandler, Arizona • Phoenix, Arizona + 73 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2012 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional

Maladaptive Psychosocial Beliefs and Adolescents With Patellofemoral Pain

NCT04752501
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Knee Pain Chronic, Patellofemoral Syndrome, Anterior Knee Pain Syndrome
Interventions
Psychologically Informed Education, Biomedical Education (Control)
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional Results available

Use of Repetitive Transcranial Magnetic Stimulation to Augment Hypnotic Analgesia

NCT02969707
View directory record Official record
Conditions
Fibromyalgia
Interventions
MagPro TMS system (MagVenture, Denmark), Hypnosis
Device · Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Phase 2 Interventional Results available

Phase 2 DaxibotulinumtoxinA for Injection for the Management of Plantar Fasciitis

NCT03137407
View directory record Official record
Conditions
Plantar Fasciitis
Interventions
Botulinum Toxins, Type A, Placebo
Biological
Lead sponsor
Revance Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
5
States / cities
Duluth, Georgia • Des Plaines, Illinois • Overland Park, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2023 · Synced Oct 24, 2026, 8:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Enhancing Analgesia in Chronic Pain Through Exercise

NCT04862871
View directory record Official record
Conditions
Pain, Chronic Widespread Pain, Fibromyalgia
Interventions
Physical Activity - Pediatric Pain Rehabilitation Center
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
10 Years to 24 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 24, 2026, 8:35 AM EDT
Terminated Not applicable Interventional

Complementary Management of Chronic Neck and/or Low Back Pain With a Pain Relief Kit

NCT03157544
View directory record Official record
Conditions
Pain, Chronic, Musculoskeletal Pain, Low Back Pain, Neck Pain
Interventions
multimodal non-pharmacological Pain Relief Kit
Behavioral
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
2
States / cities
Fairfax, Virginia • McLean, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 2, 2024 · Synced Oct 24, 2026, 8:35 AM EDT
Recruiting Not applicable Interventional

Cryoneurolysis of the Suprascapular Nerve for Perioperative Pain Control After Receiving a Reverse Total Shoulder Arthroplasty (RTSA)

NCT07125833
View directory record Official record
Conditions
Degenerative Joint Disease of Shoulder
Interventions
Cryoneurolysis, No cryoneurolysis
Device · Other
Lead sponsor
North Texas Medical Research Institute, PLLC
Other
Eligibility
30 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rockwall, Texas
Source: ClinicalTrials.gov public record
Updated Aug 15, 2025 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional

The Effects of Group Cycling (Spinning®) With Knee Osteoarthritis: A Randomized Control Trial

NCT00917618
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Exercise, Control
Other
Lead sponsor
Mercy Hospital, Pittsburgh, PA
Other
Eligibility
45 Years to 75 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Effectiveness of Acupuncture in Relieving Pain Due to Fibromyalgia

NCT00142597
View directory record Official record
Conditions
Fibromyalgia
Interventions
Acupuncture, Sham treatment
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Oct 24, 2026, 8:35 AM EDT
Terminated Phase 3 Interventional Results available

Safety of Buprenorphine Transdermal Patch (BTDS) in Osteoarthritis Pain: a 52-Week Extension Phase

NCT01135524
View directory record Official record
Conditions
Osteoarthritis
Interventions
Buprenorphine transdermal patch
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
40 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
89
States / cities
Alabaster, Alabama • Birmingham, Alabama • Fairfield, Alabama + 75 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2012 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Phase 4 Interventional Results available

Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis

NCT01225991
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Milnacipran
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Mindfulness and Yoga in Basic Combat Training

NCT05550610
View directory record Official record
Conditions
Depressive Symptoms, Anxiety, Sleep, Emotion Regulation, Pain, Military Operations, Cohesion, Social, Mindfulness, Yoga, Leadership, Health, Subjective, Stress, Mood, Musculoskeletal Injury
Interventions
Mindfulness Based Attention Training (MBAT) and Yoga
Behavioral
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
17 Years and older
Enrollment
1,896 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Fort Jackson, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Oct 24, 2026, 8:35 AM EDT
Recruiting Not applicable Interventional

Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty

NCT04814082
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Osteoarthritis, Osteoarthritis Knees Both, Osteoarthritis Knee Left, Osteoarthritis Knee Right, Knee Pain Chronic, Knee Disease, Arthropathy of Knee Joint
Interventions
MicroPort Evolution Medial-Pivot Knee System (Cruciate-substituting), Stryker Triathlon Tritanium Knee System (Condylar Stabilizing)
Device
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 22, 2025 · Synced Oct 24, 2026, 8:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty

NCT02607579
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Exparel, Ropivacaine
Drug
Lead sponsor
Monmouth Medical Center
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Long Branch, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional

Rheumatoid Arthritis Coping Enhancement

NCT04246827
View directory record Official record
Conditions
Rheumatoid Arthritis, Obesity, Pain
Interventions
Enhanced Lifestyle Weight Management
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 29, 2020 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional

Device for Alleviating Temporomandibular Joint (TMJ) Pain

NCT07624539
View directory record Official record
Conditions
Temporomandibular Joint Disorders, Facial Pain, Temporomandibular Joint Dysfunction Syndrome
Interventions
Treatment with BTL-043
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Steamboat Springs, Colorado • Leesburg, Florida • Ocala, Florida
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Phase 4 Interventional Results available

Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department

NCT01538745
View directory record Official record
Conditions
Abdomen, Acute, Other Acute Pain, Flank Pain, Back Pain, Musculoskeletal Pain
Interventions
Ketamine, Morphine
Drug
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 59 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Oct 24, 2026, 8:35 AM EDT
Completed Not applicable Interventional Results available

The Effects of CBT and tDCS on Fibromyalgia Patients

NCT02723175
View directory record Official record
Conditions
Fibromyalgia, Chronic Pain
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 28, 2018 · Synced Oct 24, 2026, 8:35 AM EDT