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Showing 1–24 of 419 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Periodontal Diseases Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Atlas of Experimental Gingivitis in Humans

NCT04105569
View directory record Official record
Conditions
Gingivitis
Interventions
Stent-Induced Biofilm Overgrowth
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 30 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 11, 2020 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Phase 3 Interventional

Effects of Low-Dose Doxycycline on Oral Bone Loss

NCT00066027
View directory record Official record
Conditions
Periodontitis
Interventions
20 mg doxycycline hyclate, Placebo
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
45 Years to 70 Years · Female only
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
2
States / cities
Lincoln, Nebraska • Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites

NCT03570333
View directory record Official record
Conditions
Gingival Recession, Lack of Keratinized Gingiva (Disorder)
Interventions
progenitor potential of Gingival Mesenchymal cells
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 19, 2026, 2:32 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults

NCT01376791
View directory record Official record
Conditions
Periodontal Disease, Atherosclerosis
Interventions
Not listed
Lead sponsor
San Diego State University
Other
Eligibility
21 Years to 40 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Valley Center, California
Source: ClinicalTrials.gov public record
Updated Apr 22, 2013 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ridge Preservation Following Tooth Extraction Using Two Mineralized Cancellous Bone Allografts

NCT02515058
View directory record Official record
Conditions
Alveolar Bone Loss
Interventions
PUROS (Ridge Preservation bone grafting surgery), FDBA (Ridge Preservation bone grafting surgery)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Phase 3 Interventional

Control of Periodontal Infections

NCT01098448
View directory record Official record
Conditions
Periodontitis
Interventions
scaling and root planing, local tetracycline, systemic metronidazole and amoxicillin, surgery, local antibiotics and systemic metronidazole and amoxicillin, local tetracycline and periodontal surgery, periodontal surgery and systemic metronidazole and amoxicillin, surgery, local tetracycline, systemic metronidazole and amoxicillin
Other · Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
20 Years and older
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2010 · Synced Sep 19, 2026, 2:32 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effect of Obesity on Oral Peri-implant Health - A Cross-Sectional Study

NCT01878071
View directory record Official record
Conditions
Obesity, Peri-implant Inflammation, Peri-implantitis
Interventions
Not listed
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2012
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 19, 2014 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease

NCT02750943
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous Fluoride, Sodium Monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Instructed Dental Flossing on Interdental Gingival Bleeding: A Randomized Controlled Clinical Trial

NCT04218994
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Flossing technique
Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 5, 2020 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Two Different Surgical Approaches To Increase Peri-Implant Mucosa Thickness

NCT02450383
View directory record Official record
Conditions
Tooth Loss, Peri-implant Mucosa Defect
Interventions
Acellular Dermal Matrix, Autologous subepithelial connective tissue graft
Drug · Procedure
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluate Inflammation Caused by Gingivitis in Adults

NCT00941668
View directory record Official record
Conditions
Gingivitis
Interventions
Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2015 · Synced Sep 19, 2026, 2:32 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

IL29 and IL28B Variants Associated With Periodontal Disease Pathogenesis

NCT02710903
View directory record Official record
Conditions
Periodontitis
Interventions
Stent-induced biofilm overgrowth
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study is to Evaluate a Regimen on Gingivitis Using Traditional and Novel Assessment Methods

NCT07211061
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous Fluoride Dentifrice, Sodium Fluoride Dentifrice, electric toothbrush, Cetylpyridinium Chloride (CPC), manual toothbrush
Drug · Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional

Brief Title: a Clinical Study to Assess Gingivitis

NCT06659471
View directory record Official record
Conditions
Gingival Diseases
Interventions
0.76% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of the Anti-Inflammatory Effects of Colgate Total® During an Experimental Gingivitis Model

NCT01799226
View directory record Official record
Conditions
Gingivitis
Interventions
Toothpaste without triclosan, Triclosan
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI)

NCT05782348
View directory record Official record
Conditions
Adolescent Behavior, Dental Plaque, Gingivitis, Cognitive Change
Interventions
Cognitive behavioral intervention, Colgate smart toothbrush
Behavioral · Other
Lead sponsor
Howard University
Other
Eligibility
14 Years to 17 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Protocol Efficacy of Mouthwashes in Experimental Gingivitis

NCT07270952
View directory record Official record
Conditions
Gingivitis
Interventions
StellaLife, Chlorhexidine
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 35 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Dec 7, 2025 · Synced Sep 19, 2026, 2:32 AM EDT
Enrolling by invitation Not applicable Interventional

Efficacy of Non-surgical and Surgical Surface Decontamination Methods on Peri-implantitis-affected Implants

NCT06430268
View directory record Official record
Conditions
Peri-Implantitis, Dental Implant Failed
Interventions
implant decontamination with titanium curette, implant decontamination with Air-Flow device
Procedure · Device
Lead sponsor
Andrea Ravida
Other
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 19, 2026, 2:32 AM EDT
Not yet recruiting Phase 4 Interventional

Endodontic Microsurgery

NCT06776289
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Platelet rich fibrin
Biological
Lead sponsor
Mark Schachman
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 19, 2026, 2:32 AM EDT
Recruiting Not applicable Interventional

Patient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques

NCT06892496
View directory record Official record
Conditions
Mucosal Erosion, Gingival Recession
Interventions
Visual Analog scale (VAS) questionnaire, Vacuum-formed retainer (VFR) technique, 3-D printed acrylic resin stent (3DS) technique, Flowable resin composite stent (FRC) technique, Photographs of the patient's palate, Measuring graft dimensions, Chairside Polymer Stent
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

To Measure Pain Perception Following De-Epithelized Free Gingival Graft Harvesting

NCT03895476
View directory record Official record
Conditions
Gingival Recession, Palate; Wound
Interventions
palatal wound will be cover with collagen and sutures, palatal wound covered with platelet rich fibrin, palatal wound covered with a collagen sponge and cyanoacrylate, palatal wound covered with a stent
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 70 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Sep 19, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Correlation Between Oral Health and Systemic Inflammation (COHESION)

NCT03641989
View directory record Official record
Conditions
Inflammation, Periodontal Disease, Gingivitis
Interventions
Plaque disclosing toothpaste, Non-plaque disclosing toothpaste
Other
Lead sponsor
Marshfield Clinic Research Foundation
Other
Eligibility
21 Years to 84 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Marshfield, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Sep 19, 2026, 2:32 AM EDT
Terminated No phase listed Interventional Results available

Safety and Efficacy of Periodontal Surgery in Supra-alveolar-type Defects With or Without Straumann® Emdogain

NCT01614925
View directory record Official record
Conditions
Periodontal Attachment Loss, Periodontal Diseases
Interventions
Emdogain, Periodontal surgery
Device · Procedure
Lead sponsor
Institut Straumann AG
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 30, 2020 · Synced Sep 19, 2026, 2:32 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Influence of Implant Crown Transmucosal Contour Design on Soft and Hard Tissue Clinical Outcomes

NCT06185075
View directory record Official record
Conditions
Gum Disease
Interventions
Implant crown delivery
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
20 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 19, 2026, 2:32 AM EDT